Amyloid-β deposition in basal frontotemporal cortex is associated with selective disruption of temporal mnemonic discrimination
Casey R. Vanderlip,
Lisa Taylor,
Soyun Kim
et al.
Abstract:Cerebral amyloid-beta (Aβ) accumulation, a hallmark pathology of Alzheimer’s disease (AD), precedes clinical impairment by two to three decades. However, it is unclear whether Aβ contributes to subtle memory deficits observed during the preclinical stage. The heterogenous emergence of Aβ deposition may selectively impact certain memory domains, which rely on distinct underlying neural circuits. In this context, we tested whether specific domains of mnemonic discrimination, a neural computation essential for ep… Show more
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