Amyloid-β and caspase-1 are indicators of sepsis and organ injury
Amanda N. Tuckey,
Arcole Brandon,
Yasaman Eslaamizaad
et al.
Abstract:BackgroundSepsis is a life-threatening condition that results from a dysregulated host response to infection, leading to organ dysfunction. Despite the prevalence and associated socioeconomic costs, treatment of sepsis remains limited to antibiotics and supportive care, and a majority of intensive care unit (ICU) survivors develop long-term cognitive complications post- discharge. The present study identifies a novel regulatory relationship between amyloid-β (Aβ) and the inflammasome-caspase-1 axis as key inna… Show more
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