Amyloid P-Component: Structure and Properties

Pepys, Mark B.

doi:10.1007/978-94-009-4309-4_5

Cited by 16 publications

(4 citation statements)

References 42 publications

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“…The concentration of SAP, the most likely source of AP deposited in tissues [5,8], is also low at birth but rises during a few weeks to the adult range [5], It is not known whether the deposition of AP in the skin and testis is age-or maturity-related [4. 9], The same applies to the present results from renal glomeruli.…”

Section: Discussionmentioning

confidence: 99%

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Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Rantala

Helin²,

Mustonen³

et al. 1997

Nephron

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Amyloid P component (AP) is a matrix glycoprotein of adult renal glomeruli. To establish whether the deposition of AP in glomeruli is an age-related phenomenon, this study used indirect immunofluorescence (IF) to investigate 34 renal biopsy specimens and 11 renal autopsy specimens. The biopsy specimens were taken from 9 patients (age range from 2 to 38 years) with normal glomerular morphology and from 25 patients (age range from 4 to 56 years) with various renal diseases. All autopsy specimens (age range form 2 months to 28 years) showed normal glomerular morphology. AP was not detected in glomeruli before age 6. By age 14, the IF intensity reached the level of the adult specimens, in which a strong fluorescence was seen along the basement membranes and within the mesangial matrix. In renal diseases, glomerular AP also appeared after age 6, although varying in its location and intensity. In conclusion, our results indicate that the appearance of AP in glomeruli is an age-related phenomenon, the pattern of which varies in renal diseases.

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Section: Discussionmentioning

confidence: 99%

“…In spite of its close similarity with C-reactive protein, SAP does not act as an acute-phase reactant in humans [5,8]. Because of a remarkable similarity between SAP and tissue AP, it is believed that serum is the source of tissue-bound AP [5,8],…”

Section: Introductionmentioning

confidence: 99%

Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Rantala

Helin²,

Mustonen³

et al. 1997

Nephron

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“…Subsequent work also showed the involvement of several other BMPs: laminin, collagen IV, and entactin 21 . A separate line of investigation by others implicated yet another constituent of basement membranes, serum amyloid P (SAP) 22 …”

Section: Common Structural Components In Amyloidmentioning

confidence: 99%

Can Deposition of Amyloid Be Prevented in Alzheimer's Disease?^a

Kisilevsky

1997

Annals of the New York Academy of Sciences

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Amyloid is a generic term referring to extracellular fibrillar protein deposits defined by their unique tinctorial, ultrastructural, and protein conformational properties. At least 17 different forms have been identified. In each form the deposit consists of a disease-specific (or pathologic process-specific) protein and a set of common components. The disease-specific protein serves as the basis for the classification of the amyloids. In inflammation-associated (AA) amyloid it can be demonstrated that interactive processes between serum amyloid A (SAA), the AA precursor, and the common components, are likely responsible for AA amyloid deposition. Understanding the details of these interactions provide targets for therapeutic interference that are successful in vivo. Analogous interactions take place between the common components and the beta-protein and beta-protein precursor responsible for the congophilic angiopathy and neuritic plaque amyloid in Alzheimer's disease. Interference with beta-protein/common component interaction in vitro both prevents and reverses beta-protein fibril assembly, indicating that successful delivery of effective agents across the blood-brain barrier should prevent and possibly reverse amyloid deposition in Alzheimer's disease.

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“…Although serum amyloid P (SAP) and C-reactive protein (CRP) are considered members of the same plasma protein family, CRP has not been consistently recognized to be associated with cerebral amyloid deposits. This may be because of the different behaviors of the two pentraxins in humans (57). However, I (37) and Strauss et al (58) observed CRP-like immunoreactivity in a subpopulation of cortical amyloid deposits in AD.…”

Section: Acute Phase Proteins and Associated Factorsmentioning

confidence: 99%

The Immunopathology of Alzheimer's Disease and Some Related Disorders

Kalaria

1993

Brain Pathology

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Current evidence clearly indicates that elements of the immune system are involved in the pathogenesis of the principal lesions characterizing Alzheimer's disease (AD). Findings are in accord with features associated with both the innate and adaptive immune mechanisms involved in a predominantly local inflammatory response within the parenchyma. Many of the features are unique to AD, presumably related to the unusual properties of beta amyloid protein. Remarkably, the brain holds the capacity to produce almost all the immune system mediators which largely seem to be generated by glia comprising both astrocytes and microglia. While a variety of humoral mediators including classical acute phase proteins (and serpins) are increased and released, the complement seems most intrinsically involved. The cellular response is elaborated by microglia which seem the main immunocompetent cells partaking in the response. These appear to function as pluripotent macrophages expressing both classes of MHC antigens. Further characterization of this interesting response to cerebral amyloidosis will be challenging.

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Amyloid P-Component: Structure and Properties

Cited by 16 publications

References 42 publications

Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Can Deposition of Amyloid Be Prevented in Alzheimer's Disease?^a

The Immunopathology of Alzheimer's Disease and Some Related Disorders

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Amyloid P-Component: Structure and Properties

Cited by 16 publications

References 42 publications

Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Can Deposition of Amyloid Be Prevented in Alzheimer's Disease?a

The Immunopathology of Alzheimer's Disease and Some Related Disorders

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Product

Resources

About

Can Deposition of Amyloid Be Prevented in Alzheimer's Disease?^a