Amyloid-like nanofibrous network confined and aligned ultrafine bimetallic nanozymes for smart antibacterial therapy

Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

“…Similarly, Feng's team co-reduced gold and copper ions onto the nanofiber network of lysozyme to form ultrasmall LNF/Au 3 Cu 1 HSNW nanozymes. 20 The bimetallic alloy Au 3 Cu 1 HSNW demonstrated lower energy barriers for both H 2 O 2 adsorption to the active sites and H 2 O 2 activation than the monometallic Au HSNW, indicating that the alloy nanozymes facilitated the conversion of H 2 O 2 more efficiently.…”

“…First, H 2 O 2 is adsorbed onto the active site of the nanozyme surface, forming *H 2 O 2 (*represents the adsorbed substance). 20,21 In the homolytic pathway, the O–O bond in *H 2 O 2 is cleaved to form two *OH, with one *OH subsequently desorbing to generate ˙OH. In the heterolytic pathway, *H 2 O 2 splits into *H 2 O + O, followed by protonation of *O to form *OH + H 2 O, and finally, the desorption of H 2 O to yield *OH.…”

CaO2–Cu2O micromotors accelerate infected wound healing through antibacterial functions, hemostasis, improved cell migration, and inflammatory regulation

“…Presently, for the treatment of deep wounds, numerous recently developed antibacterial particles, including nanoenzymes and a combination of photothermal therapy and simulated enzyme catalysis, exhibit outstanding antibacterial effectiveness and tissue repair capabilities. 18–20 In contrast to certain metallic or precious metal nanoenzymes, the preparation process for CaO 2 –Cu 2 O does not necessitate any specialized equipment, resulting in lower costs while still achieving desirable therapeutic effects.…”

Phytic Acid-Promoted Deposition of Gold Nanoparticles with Grafted Cationic Polymer Brushes for the Construction of Synergistic Contact-Killing and Photothermal Bactericidal Coatings

“…In order to reduce the side effect of APTT, combining the photothermal agents with other antimicrobial strategies to produce a synergistic antimicrobial effect is a plausible solution. − So far, many antimicrobials and strategies, such as cationic polymers, nitric oxide (NO)-releasing drugs, redox and Fenton reaction-triggered reactive oxygen species (ROS), − surface hydration, , antibiotics, , quorum sensing inhibitors, silver ions, , and photodynamic therapy, − have been integrated with photothermal agents to construct synergistic antibacterial platforms. Among them, cationic polymers have contact bactericidal functions, which rely on their positively charged cations to contact, penetrate, and compromise the negatively charged bacterial cell membranes .…”