Amyloid goiter: radiologic findings.

Hatabu, Hiroto; Iida, Yasuhiro; Kasagi, Kanji; Yamamoto, Kanji; Hidaka, Akinari; Tatsumi, H; Higuchi, Kayoko; Konishi, Junji

doi:10.2214/ajr.155.1.2112846

Cited by 13 publications

(7 citation statements)

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“…Few cases of hypothyroidism or hyperthyroidism have been reported (11). T-99 pyrophosphate, ultrasound computed tomography, and magnetic resonance imaging studies are nonspecific (12). Hyperechoic feature and fine homogeneous texture of the goiter have been described at ultrasound examination (13).…”

Section: Discussionmentioning

confidence: 99%

Amyloid Goiter as the Initial Manifestation of Systemic Amyloidosis due to Familial Mediterranean Fever with Homozygous MEFV Mutation

Sbaï

Wechsler²,

Leenhardt³

et al. 2001

Thyroid

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We describe a case of amyloid goiter revealing a systemic amyloidosis secondary to familial Mediterranean fever (FMF) with homozygous MEFV mutation, and we review the literature. A 45-year-old euthyroid Sephardic man, known to suffer from FMF, developed a goiter with cold nodule, after which a subtotal thyroidectomy was performed. Histologic evaluation revealed diffuse AA amyloid deposition without any associated thyroid neoplasia. At that time, no other organ was found to be affected by amyloidosis. Colchicine and levothyroxine were prescribed. Eight years later, the patient presented with a rapidly growing neck enlargement. He reported that he had discontinued colchicine therapy 2 years earlier. The serum thyrotropin (TSH) and calcitonin levels were normal. Renal, digestive, and salivary gland biopsies confirmed the presence of systemic AA amyloidosis. Despite the reintroduction of colchicine, the onset of compressive symptoms led to the completion of the total thyroidectomy. The histopathology again demonstrated amyloid deposition, and excluded a malignant neoplasm. Nine cases of amyloid goiter associated with FMF have been reported in the literature; none of them had an amyloid goiter as the first manifestation of systemic amyloidosis. To our knowledge, this is the first case of FMF in which an amyloid goiter preceded the development of secondary systemic amyloidosis. The cessation of colchicine therapy may have played a role in local relapse and the secondary spread of amyloid deposits.

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Section: Discussionmentioning

confidence: 99%

Amyloid Goiter as the Initial Manifestation of Systemic Amyloidosis due to Familial Mediterranean Fever with Homozygous MEFV Mutation

Sbaï

Wechsler²,

Leenhardt³

et al. 2001

Thyroid

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“…9,10 In cases with a predilection for amyloid deposits, complex or hypoechoic masses are shown on sonography, and in cases with regressive changes, cystic lesions are observed. 9,11,12 Computed tomography can confirm diffuse fatequivalent hypodensity or hypodense amyloid deposits, sometimes with fine calcifications. [10][11][12] On MRI, fatty infiltration causes increased intensity both on T1-and T2-weighted images and suppression on fat-saturated sequences.…”

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confidence: 99%

Diffuse Fatty Infiltration of the Thyroid Gland in Amyloidosis

Aksu

Ozmen

Oğuz

et al. 2010

Journal of Ultrasound in Medicine

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“…MRI investigation of amybid goiter has so far produced various findings. High intensity Hatabu et al (1990) reported diffuse uptake of 1231 in amyloid goiter. In the present case, both 1231 and 99mTc pertechnetate scintigram showed diffuse uptake of the isotope in the enlarged thyroid gland with no focal defect or hot uptake.…”

Section: Discussionmentioning

confidence: 97%

“…28(1996) ________________ E. ishimura, T. Okamura, H. Masaki, V. Hiura, T. Kawagishietal. of the gland was reported by Hatabu et al (1990), due to hemorrhage in the amyloid gland. Perez-Fontan et al (1992) reported focal, high intensity mass of amyloid deposition in the thyroid.…”

Section: Discussionmentioning

confidence: 98%

“…There have been a few reports on radiological findings in amybid goiter (El-Reshaid, Al-Temami, Johny, Madda and Hakim 1994;Hatabu, lida, Kasagi, Yamamoto, Hidaka, Tatsumi, Higuchi and Konishi 1990;Miyake, Maeda, Isomoto, Nagatomo, Nakashima and Ashizawa 1988;Mche, Schwingshandl, Riccabona, Ranner, Ring, Fock, Ratschek and Malle 1993;Perez-Foriton, Mosquera-Oses, Pombo-Felipe, Ridriguez-Sanchez and ArnaizPena 1992;Lee, Rubi now, Pehrson, Skinner and Cohen 1984). Miyake et al and Hatabu et al have reported on CT findings in amyloid goiter.…”

Section: Discussionmentioning

confidence: 99%

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Amyloid Goiter: Radiological Study in a Case Presenting Hypothyroidism

Ishimura¹,

Okamura²,

Masaki³

et al. 1996

Horm Metab Res

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We report herein a case of amyloid goiter associated with rheumatoid arthritis in which hypothyroidism was observed. A 52-year-old housewife who had suffeed from rheumatoid arthritis for 15 years was referred to our hospital because of general fatigue. On admission, a large goiter was observed. Laboratory data showed primary hypothyroidism. Renal biopsy and gastric mucosa biopsy showed amyloid deposition of AA-type. Thyroid biopsy showed massive amyloid involvement. Although the findings of iodine-123 scintigraphy, technetium-99m pertechnetate scintigraphy, computed tomography and magnetic resonance image studies were similar to those for goiter associated with chronic thyroiditis, tallium-201 chloride scintigraphy gave a differing result, demonstrating absent uptake at 3 hours in this case. Replacement therapy with levothyroxine relieved the symptoms. This case was unusual in that amyloid goiter presented clinically as hypothyroidism. Absence of tallium-201 chloride uptake at 3 hours may be a diagnostic specificity for amyloid goiter in differentiating its hypothyroidism from that caused by chronic thyroiditis.

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Amyloid goiter: radiologic findings.

Cited by 13 publications

References 0 publications

Amyloid Goiter as the Initial Manifestation of Systemic Amyloidosis due to Familial Mediterranean Fever with Homozygous MEFV Mutation

Amyloid Goiter as the Initial Manifestation of Systemic Amyloidosis due to Familial Mediterranean Fever with Homozygous MEFV Mutation

Diffuse Fatty Infiltration of the Thyroid Gland in Amyloidosis

Amyloid Goiter: Radiological Study in a Case Presenting Hypothyroidism

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