Amyloid Goiter Associated with the Nephrotic Syndrome

Bell, George O.; Mena, Benito A.

doi:10.1016/s0025-7125(16)33596-9

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Amyloid infiltration in the thyroid was first reported by von Rokitansky in 1855 [9]. Although amyloid was found in the thyroid of 50% to 80% of primary and secondary amyloidosis patients [10], it rarely appears clinically as diffuse goiter, which von Eisenberg named 'amyloid goiter.' One characteristic of amyloid goiter is its rapid growth, which makes to need to discriminate from a malignant tumor [8].…”

Section: Discussionmentioning

confidence: 99%

A Case of Systemic Amyloidosis Found by Goiter in Crohn’s Disease

Kang¹,

Jeon²,

Kim³

et al. 2013

Soonchunhyang Med Sci

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Secondary amyloidosis is characterized by accumulation of insoluble, fibrous amyloid proteins in various tissues and organs, accompanied by infectious or inflammatory diseases. Amyloidosis may involve the thyroid, gastrointestinal tract, kidneys, liver, or bone marrow. Amyloidosis as a complication of Crohn's disease is rare but serious, and may worsen the prognosis. We have experienced a case of amyloid goiter and gastrointestinal amyloidosis secondary to Crohn's disease. A 74-year-old female patient with Crohn's disease was admitted to Soonchunhyang University Hospital with general weakness and poor oral intake. Anterior-neck diffuse goiter and tenderness around the navel were found. Amyloid goiter and gastrointestinal amyloidosis diagnosed by sonoguided needle biopsy of the thyroid and endoscopic biopsies of the stomach and duodenum.

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Section: Discussionmentioning

confidence: 99%

A Case of Systemic Amyloidosis Found by Goiter in Crohn’s Disease

Kang¹,

Jeon²,

Kim³

et al. 2013

Soonchunhyang Med Sci

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“…The utrasound findings in the present case were similar to these. cally as hypothyroidism (Kanoh et al 1989;Bell and Mena 1963). Karioh et al (1989) have reported one case of amyloid goiter with hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, there have been very few reports of amyloid goiter presenting clinically as hypothyroidism (Kanoh et al 1989;Bell and Mena 1963). Diagnosis of amyloid goiter has mostly depended on thyroid biopsy, with few studies of radiological findings in cases of this condition.…”

Section: Introductionmentioning

confidence: 99%

Amyloid Goiter: Radiological Study in a Case Presenting Hypothyroidism

Ishimura¹,

Okamura²,

Masaki³

et al. 1996

Horm Metab Res

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We report herein a case of amyloid goiter associated with rheumatoid arthritis in which hypothyroidism was observed. A 52-year-old housewife who had suffeed from rheumatoid arthritis for 15 years was referred to our hospital because of general fatigue. On admission, a large goiter was observed. Laboratory data showed primary hypothyroidism. Renal biopsy and gastric mucosa biopsy showed amyloid deposition of AA-type. Thyroid biopsy showed massive amyloid involvement. Although the findings of iodine-123 scintigraphy, technetium-99m pertechnetate scintigraphy, computed tomography and magnetic resonance image studies were similar to those for goiter associated with chronic thyroiditis, tallium-201 chloride scintigraphy gave a differing result, demonstrating absent uptake at 3 hours in this case. Replacement therapy with levothyroxine relieved the symptoms. This case was unusual in that amyloid goiter presented clinically as hypothyroidism. Absence of tallium-201 chloride uptake at 3 hours may be a diagnostic specificity for amyloid goiter in differentiating its hypothyroidism from that caused by chronic thyroiditis.

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“…AG may also be secondary to long standing chronic infectious inflammatory diseases such as bronchiectasis [7] and tuberculosis [8]. The condition was reported in association with renal failure [9], nephritic syndrome [10] and familial Mediterranean fever (FMF) [11]. In autopsy specimen examination, AG was reported in 80% of patients with secondary amyloidosis and in 50% of patients with primary amyloidosis [1].…”

Section: Introductionmentioning

confidence: 99%

Amyloid Goiter: Clinicopathological Assessment of Two Cases and Review of Literature

Mohammed¹,

Yassin²,

Radwan³

et al. 2015

OJPathology

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Amyloid goiter (AG) is a rare but well-established disease entity that may occur in a number of conditions. In the following article, we will report two cases of AG. Both patients were young males: 28 & 24 years old, presented with rapidly enlarging thyroid gland manifested with pressure effects (dyspnea and hoarseness of voice). Provisional clinical diagnosis was malignant thyroid neoplasm. One of the patients was markedly hypothyroid while the other was euthyroid. Histopathological evaluation revealed extracellular deposition of deep pink homogenous material that was confirmed as amyloid with congo red. Patient in case 1 was primary localized AG while patient in case 2 was systemic amyloidosis secondary to interstitial pulmonary fibrosis (IPF) that was first manifested by AG. The main aims of the article were to describe histopathological features of amyloidosis of the thyroid gland and to raise awareness of AG to be included in the differential diagnosis in patients presented with rapidly enlarging goiter with mass effects.

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Amyloid Goiter Associated with the Nephrotic Syndrome

Cited by 7 publications

References 15 publications

A Case of Systemic Amyloidosis Found by Goiter in Crohn’s Disease

A Case of Systemic Amyloidosis Found by Goiter in Crohn’s Disease

Amyloid Goiter: Radiological Study in a Case Presenting Hypothyroidism

Amyloid Goiter: Clinicopathological Assessment of Two Cases and Review of Literature

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