Amyloid beta glycation leads to 1 neuronal mitochondrial dysfunction and Alzheimer’s pathogenesis through VDAC1-dependent mtDNA efflux
Firoz Akhter,
Asma Akhter,
Hillary Schiff
et al.
Abstract:Amyloid beta (Aβ), a stable protein, undergoes posttranslational glycation, forming glycated Aβ (gAβ), an advanced glycation end product (AGE) observed in Alzheimers' disease (AD), yet the pathological role of gAβ remains understudied. This work explores the role of gAβ in inducing neuronal mitochondrial DNA (mtDNA) efflux in a VDAC1-dependent manner and in activating the innate immune cGAS-STING pathway in AD. Findings demonstrate cGAS-mtDNA binding induced by gAβ in neuro-cytoplasm along with cGAS-STING acti… Show more
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