Amyloid angiopathy-related cerebellar hemorrhage

Cuny, Emmanuel; Loiseau, Hugues; Rivel, J; Vital, C; Castel, Jean-Pierre

doi:10.1016/0090-3019(96)00158-9

Cited by 26 publications

(19 citation statements)

References 19 publications

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“…However, our results do not confirm the findings of an autopsy series in which CAA was found in 14.3% of patients with cerebellar haemorrhage [26]. In accordance with our findings, in clinical studies, CAA was reported only anecdotally as the cause of SCH [27, 28]. …”

Section: Discussioncontrasting

confidence: 52%

Long-Term Outcome after Spontaneous Cerebellar Haemorrhage

Dolderer

Kallenberg²,

Aschoff³

et al. 2004

Eur Neurol

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We analysed the clinical and radiological findings and the long-term outcome after 49 ± 34 months in 75 patients (42 men, aged 67 ± 11 years) with spontaneous cerebellar haemorrhage (SCH). At the follow-up examination, 36 patients had died. Outcome was excellent [Rankin Scale (RS) score 0 + 1] in 22 survivors, 4 patients were moderately (RS score 2 + 3) and 13 patients were severely disabled (RS score 4 + 5). Prognostic factors are haematoma volume, intubation, hydrocephalus and clinical signs of brainstem involvement. Of the 28 surgically treated patients, outcome was favourable (RS score 0–2) in 4 patients only, 6 were severely disabled (RS score 3–6) and 18 patients had died. We conclude that the long-term outcome after SCH is frequently favourable. Because patients who were surgically treated had less favourable clinical and radiological findings, a good long-term outcome was rarely present in this group.

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Section: Discussioncontrasting

confidence: 52%

Long-Term Outcome after Spontaneous Cerebellar Haemorrhage

Dolderer

Kallenberg²,

Aschoff³

et al. 2004

Eur Neurol

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“…Cerebellar hemorrhage in CAA-related ICH occurs only rarely, with less than 10 cases reported previously (Cuny et al, 1996). In our series 2 patients (4.9%), who also had a history of HTN, had cerebellar hemorrhages in CAA.…”

Section: Discussionmentioning

confidence: 73%

Study of clinical features of amyloid angiopathy hemorrhage and hypertensive intracerebral hemorrhage

Zhan

Tong

Shen

et al. 2004

J. Zheijang Univ.-Sci.

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Abstract:Objective: The purpose of this study was to differentiate between cerebral amyloid angiopathy (CAA) and hypertension (HTN) based on hemorrhage pattern interpretation. Methods: From June 1994 to Oct., 2000, 83 patients admitted to our service with acute intracerebral hemorrhage (ICH) were investigated retrospectively; 41 patients with histologically proven diagnosis of cerebral amyloid angiography and 42 patients with clear history of hypertension were investigated. Results: Patients with a CAA-related ICH were significantly older than patients with a HTN-related ICH (74.0 years vs 66.5 years, P<0.05). There was a significantly higher number of hematomas≥30 ml in CAA (85.3%) when compared with HTN (59.5%). No basal ganglional hemorrhage was seen in CAA, but in 40.5% in HTN. In CAA-related ICH, subarachnoid hemorrhage (SAH) was seen in 26 patients (63.4%) compared to only 11 patients (26.2%) in HTN-related ICH. Intraventricular hemorrhage was seen in 24.4% in CAA, and in 26.2% in HTN. Typical features of CAA-related ICH included lobar distribution affecting mainly the lobar superficial areas, lobulated appearance, rupture into the subarachnoid space, and secondary IVH from the lobar hemorrhage. More specifically, multiplicity of hemorrhage, bilaterality, and repeated episodes also strongly suggest the diagnosis of CAA. Multiple hemorrhages, defined as 2 or more separate hematomas in multiple lobes, accounted for 17.1% in CAA-related ICH. Conclusion: There are certain features in CAA on CT and MRI and in clinical settings. To some extent, these features may contribute to distinguishing CAA from HTN related ICH.

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“…The cerebellum is known to contain a variable amount of vascular amyloid and can rarely be the site of hemorrhage [20,21]. Because lobar hemorrhages occur in cortical regions near the pial surface, dissection of the hematoma into the subarachnoid space is common.…”

Section: Clinical Features Of Cerebral Amyloid Angiopathymentioning

confidence: 99%

Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria

Smith

Greenberg

2003

Curr Atheroscler Rep

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Cerebral amyloid angiopathy is a disorder in which deposition of amyloid within the arterial media and adventitia leads to intracerebral hemorrhage. Diagnosis during life has been hampered by the requirement for post-mortem examination for definitive diagnosis. The Boston Criteria for the diagnosis of cerebral amyloid angiopathy-related hemorrhage were developed in 1995 and 1996 in order to meet the need for a standardized set of diagnostic criteria that can be applied to living patients. Using a combination of clinical, radiologic, and pathologic data, these criteria reliably differentiate lobar intracerebral hemorrhage into categories of possible, probable, or definite based on the likelihood of underlying cerebral amyloid angiopathy. These criteria will be crucial for disease classification for future clinical studies.

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Amyloid angiopathy-related cerebellar hemorrhage

Cited by 26 publications

References 19 publications

Long-Term Outcome after Spontaneous Cerebellar Haemorrhage

Long-Term Outcome after Spontaneous Cerebellar Haemorrhage

Study of clinical features of amyloid angiopathy hemorrhage and hypertensive intracerebral hemorrhage

Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria

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