Amyloid and hyaline globules in undifferentiated nasopharyngeal carcinoma

Khan, Irfan Sagir; Loh, Kwok Seng; Petersson, Fredrik

doi:10.1016/j.anndiagpath.2019.02.016

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…In the salivary gland, it has been reported that amyloid deposition surrounded by tumor cells could be seen in EBV‐associated LEC 16 . Also, Khan et al reported that two cases of nasopharyngeal LEC were detected amyloid deposition, and were immunoreactive for pan‐cytokeratin, AE1/3 17 . Similarly, the deposited amyloid in the present case was immunoreactive for 34betaE12 which are composed of CK1, 5, 10, and 14 cocktails, and also immunoreactive for CK5.…”

Section: Discussionsupporting

confidence: 69%

“…16 Also, Khan et al reported that two cases of nasopharyngeal LEC were detected amyloid deposition, and were immunoreactive for pan-cytokeratin, AE1/3. 17 Similarly, the deposited amyloid in the present case was immunoreactive for 34betaE12 which are composed of CK1, 5, 10, and 14 cocktails, and also immunoreactive for CK5. Cytokeratin-derived amyloid deposition is observed in various skin tumors represented by basal cell carcinoma.…”

Section: Discussionsupporting

confidence: 68%

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Carcinoma showing thymus‐like elements (CASTLE) with amyloid deposition in the parotid gland

Hamada,

Miyama,

Matsumura

et al. 2024

Pathology International

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Carcinoma showing thymus‐like elements (CASTLE) is a rare tumor that commonly occurs in the thyroid gland. Extrathyroidal CASTLE is rarer, and only 11 cases of CASTLE of major salivary glands have been reported to date. We report the first case of amyloid deposition in parotid CASTLE. A 63‐year‐old man presented with a slowly growing mass in the left parotid region. Computed tomography revealed an approximately 28 × 23 mm mass lesion in the left parotid gland, and squamous cell carcinoma was suspected on biopsy. The patient underwent a parotidectomy with neck dissection. Morphologically, the tumor cells were squamoid and formed nests with lymphoid infiltration. Immunohistochemically, the tumor cells exhibited immunoreactivity for CD5, CD117/c‐kit and Bcl‐2, p40, and CK5 but not for p16. We diagnosed the tumor as parotid CASTLE. Amyloid deposition was also observed in the primary tumor and metastatic lymph node lesions, which were immunoreactive for cytokeratin 5. Tumor cytokeratin‐derived amyloid deposition may be one of characteristics of parotid CASTLE.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 68%

Carcinoma showing thymus‐like elements (CASTLE) with amyloid deposition in the parotid gland

Hamada,

Miyama,

Matsumura

et al. 2024

Pathology International

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“…Previously, different amyloids were found in a variety of tumors. Different carcinomas have amyloid stroma [54,55], and odontogenic tumors are positive for thioflavin T and Congo Red staining and are also immunopositive for the enamel matrix protein ameloblastin [56,57,58]. Similarly, amyloid was reported in breast cancer tumors but was determined to be a localized amyloid light chain (AL) type (primary amyloidosis caused by ImG light-chain β-sheeting) [59,60].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors

Kucheryavykh

Ortiz-Rivera

Kucheryavykh

et al. 2019

IJMS

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Immunostaining with specific antibodies has shown that innate amyloid beta (Aβ) is accumulated naturally in glioma tumors and nearby blood vessels in a mouse model of glioma. In immunofluorescence images, Aβ peptide coincides with glioma cells, and enzyme-linked immunosorbent assay (ELISA) have shown that Aβ peptide is enriched in the membrane protein fraction of tumor cells. ELISAs have also confirmed that the Aβ(1–40) peptide is enriched in glioma tumor areas relative to healthy brain areas. Thioflavin staining revealed that at least some amyloid is present in glioma tumors in aggregated forms. We may suggest that the presence of aggregated amyloid in glioma tumors together with the presence of Aβ immunofluorescence coinciding with glioma cells and the nearby vasculature imply that the source of Aβ peptides in glioma can be systemic Aβ from blood vessels, but this question remains unresolved and needs additional studies.

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“…Unlike systemic amyloidosis, breast cancer exhibits localized light-chain amyloidosis, with amyloid bodies limited to the inside of the tumor [5,6]. Many carcinomas have stroma containing AL-type amyloid [7,8]. Localized AL-type amyloidosis was also found in early-stage non-small-cell adenocarcinomas in kidney and lung [9].…”

Section: Introductionmentioning

confidence: 99%

Accumulation of amyloid beta in human glioblastomas

Zayas‐Santiago

Díaz-García

Nuñez-Rodríguez

et al. 2020

Clinical and Experimental Immunology

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Many cancer types are intrinsically associated with specific types of amyloidosis, in which amyloid is accumulated locally inside tumors or systemically. Usually, this condition relates to the hyperproduction of specific amylogenic proteins. Recently, we found that the accumulation of amyloid beta (Aβ) peptide immunofluorescence is linked to glioma cells in mouse tumors. Here we report that amyloid-specific histochemical dyes reveal amyloid accumulation in all human glioma samples. Application of two different antibodies against Aβ peptide (a polyclonal antibody against human Aβ1-42 and a monoclonal pan-specific mAb-2 antibody against Aβ) showed that the amyloid in glioma samples contains Aβ. Amyloid was linked to glioma cells expressing glial-specific fibrillary acidic protein (GFAP) and to glioma blood vessels. Astrocytes close to the glioma site and to affected vessels also accumulated Aβ. We discuss whether amyloid is produced by glioma cells or is the result of systemic production of Aβ in response to glioma development due to an innate immunity reaction. We conclude that amyloid build-up in glioma tumors is a part of the tumor environment, and may be used as a target for developing a novel class of anti-tumor drugs and as an antigen for glioma visualization.

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Amyloid and hyaline globules in undifferentiated nasopharyngeal carcinoma

Cited by 4 publications

References 33 publications

Carcinoma showing thymus‐like elements (CASTLE) with amyloid deposition in the parotid gland

Carcinoma showing thymus‐like elements (CASTLE) with amyloid deposition in the parotid gland

Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors

Accumulation of amyloid beta in human glioblastomas

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