Amylin is associated with delayed gastric emptying in critically ill children

Mayer, Anton; Durward, Andrew; Turner, Charles; Skellett, Sophie; Dalton, N.; Tibby, Shane M.; Murdoch, Ian A.

doi:10.1007/s00134-002-1224-7

Cited by 35 publications

(58 citation statements)

References 26 publications

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“…The observation that amylin concentrations did not appear to be a determinant of feed tolerance in this adult cohort differs from a previous report in critically ill children, in which increased serum amylin concentrations were associated with delayed gastric emptying 13 . However the latter study may have had methodological limitations including a small sample size and a heterogeneous cohort, including a wide age range 13 .…”

Section: Discussioncontrasting

confidence: 99%

“…In fasted critically ill and healthy subjects (n=26 and 23 respectively) liquid nutrient, containing 100mg 13 C-sodium octanoate and 3g 3-O-methlyglucose (3-OMG), was administered via a nasogastric tube. Amylin, GLP-1, glucose and 3-OMG concentrations were measured in blood samples taken during fasting, and 30 and 60min after the 'meal'.…”

Section: Methodsmentioning

confidence: 99%

“…Breath samples were analysed to determine the percentage of 13 C recovered per hour, plotted over time. The area under the recovery curve was used to calculate the gastric emptying coefficient (GEC), which is a global index of the gastric emptying rate that accounts for the rate of appearance and disappearance of tracer in the breath.…”

Section: Gastric Emptyingmentioning

confidence: 99%

“…Based on the study by Mayer and colleagues 13 it was decided, a priori to classify patients as tolerant or intolerant to intragastric feed and perform subgroup analysis.…”

Section: 0; Spss Il Usa)mentioning

confidence: 99%

“…Furthermore, at least in animal models, amylin appears to be a more potent physiological regulator of gastric emptying than other enterogastrones, including CCK and glucagon-like peptide-1 (GLP-1) 12 . Using gastric residual volumes (GRVs) to determine tolerance to intragastric feed, Mayer and colleagues reported that fasting plasma amylin concentrations were much higher in critically ill children who were intolerant of intragastric feed, when compared to the feed-tolerant 13 , suggesting that endogenous amylin may contribute to slow gastric emptying in the critically ill.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Summers

Bartolomeo

Zaknic

et al. 2014

Acta Anaesthesiol Scand

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Section: Discussioncontrasting

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Gastric Emptyingmentioning

confidence: 99%

“…Based on the study by Mayer and colleagues 13 it was decided, a priori to classify patients as tolerant or intolerant to intragastric feed and perform subgroup analysis.…”

Section: 0; Spss Il Usa)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Summers

Bartolomeo

Zaknic

et al. 2014

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Gastrointestinal Hormone Profiles Associated With Enteral Nutrition Tolerance and Gastric Emptying in Pediatric Critical Illness: A Pilot Study

Martinez

Panciotti

Pereira

et al. 2019

J Parenter Enteral Nutr

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Background Enteral nutrition (EN) intolerance and delayed gastric emptying are prevalent in pediatric critical illness and limit EN delivery. Gastrointestinal (GI) hormones may be associated with EN intolerance and delayed gastric emptying in this cohort. Methods We determined GI hormone levels, time to achieve 50% of EN goal, and gastric emptying in critically ill children. Total amylin, active ghrelin, total glucagon‐like peptide‐1 (GLP‐1), total gastric inhibitory polypeptide, glucagon, and total peptide‐YY (PYY) were measured by multiplex assay and cholecystokinin by ELISA. Lower concentrations of acetaminophen at 1 hour (C1h, µg/mL) using the acetaminophen absorption test defined delayed gastric emptying. Correlation, regression analyses, and a principal component analysis were used to examine the association between GI hormones and time to 50% EN goal and C1h. Results GI hormones were measured in 14 of 21 patients with gastric emptying testing; median age of 11.2 years (6.74–16.3) and 50% male. Increasing hormone levels from GI hormone profile 1 (GLP‐1, glucagon, and amylin) correlated with greater time to reach 50% EN goal (R2 = 0.296, P = 0.04). Decreasing hormone levels from GI hormone profile 2 (PYY and ghrelin) correlated with lower C1h and slower gastric emptying (R2 = 0.342, P = 0.02). Conclusion GI hormone profiles are associated with time to achieve 50% of EN goal and gastric emptying in critically ill children. We have described a feasible model to study the role of GI hormones in this cohort, including the potential clinical applicability of GI hormone measurement in the management of delayed gastric emptying.

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Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study

Martinez

Zurakowski

Pereira

et al. 2020

J Parenter Enteral Nutr

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Background: Impaired gastric emptying (GE) is associated with morbidity in surgical critically ill children. The relationship between inflammation, gut barrier integrity (lipopolysaccharide binding protein [LBP]; zonulin), and GE has not been described in this cohort. Methods: Children ≥2 years of age and requiring critical care after surgery were enrolled. Preoperative and postoperative levels of serum cytokines, LBP, and zonulin, and GE by the acetaminophen absorption test, were measured, allowing patients to serve as their own controls. Postoperative delayed GE was defined as a decrease in GE by ≥20% compared with preoperative GE. The following were examined : comparison between postoperative andpreoperative values, correlations between fold change (postoperative/preoperative) in study variables, and fold change in study variables between patients with and without postoperative delayed GE. Results: Twenty patients, median age 14 years (12.25, 18), 12 female, were included. Eight of 20 patients had postoperative delayed GE. Postoperative interleukin-6 (IL-6), IL-8, IL-10, and LBP were increased, and zonulin was decreased (P-values < .05). Fold change in IL-10 and zonulin were inversely correlated (ρ −0.618, P = .004). Patients with postoperative delayed GE had greater fold increase in IL-10 (P = .0159) and fold decrease in zonulin (P = .0160). Five of 7 (71%) patients with both fold increase in IL-10 and decrease in zonulin had delayed GE. Conclusion: Postoperative changes in IL-10 and zonulin were associated with delayed GE in surgical critically ill children, which might suggest a mechanism to for delayed GE in postoperative inflammation and gut barrier dysregulation after surgery.

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Amylin is associated with delayed gastric emptying in critically ill children

Cited by 35 publications

References 26 publications

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Gastrointestinal Hormone Profiles Associated With Enteral Nutrition Tolerance and Gastric Emptying in Pediatric Critical Illness: A Pilot Study

Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study

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