Amylin and Selective Glucoregulatory Peptide Alterations during Prolonged Exercise

Francois, Michelle; Sehgal, Kiran; Sirikul, Bovorn; Valverde, Roldán A.; Castracane, V. Daniel

doi:10.1249/mss.0b013e3182114ab9

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…Body composition was first determined using a 7‐site skinfold assessment (Kraemer et al. ). The subjects then completed a graded exercise treadmill test (Kraemer Protocol, [Kraemer et al.…”

Section: Methodsmentioning

confidence: 99%

“…The subjects then completed a graded exercise treadmill test (Kraemer Protocol, [Kraemer et al. ]) beginning at 2.5 miles·h −1 , 4% grade, and progressing by 1 mile·h −1 every 2 min until exhaustion. Expired gas volumes, F E O 2 , and F E CO 2 were continually collected and analyzed using a metabolic cart (ParvoMedics 2400, Sandy, UT).…”

Section: Methodsmentioning

confidence: 99%

“…Seven young male subjects were prescreened, signed informed consent to participate in the study, and completed a 3-day food record as well as a medical history questionnaire. Subjects were a subset of a previous study investigating glucoregulatory hormone responses to exercise (Kraemer et al 2011) and met the following criteria for participation: (1) between ages 18 and 35 years; (2) not taking any prescription medications, (3) not adhering to a diet that would affect metabolic responses to exercise, and (4) had no history of metabolic or cardiorespiratory disease.…”

Section: Human Subjectsmentioning

confidence: 99%

“…All seven subjects reported to the laboratory and completed a preliminary exercise trial to determine body composition and maximal oxygen uptake (VO 2 max). Body composition was first determined using a 7-site skinfold assessment (Kraemer et al 2011). The subjects then completed a graded exercise treadmill test (Kraemer Protocol, [Kraemer et al 2011]) beginning at 2.5 milesÁh À1 , 4% grade, and progressing by 1 mileÁh À1 every 2 min until exhaustion.…”

Section: Preliminary Trialsmentioning

confidence: 99%

“…Hemoglobin concentrations from whole blood were determined using an enzymatic colorimetric method (Pointe Scientific), and hematocrit was determined using a microhematocrit method. Hemoglobin and hematocrit were used to determine plasma volume shifts over time (Kraemer et al 2011).…”

Section: Blood Sample Processingmentioning

confidence: 99%

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Plasma cell-free mitochondrial DNA declines in response to prolonged moderate aerobic exercise

et al. 2016

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Increased plasma cell‐free mitochondrial DNA (cf‐mDNA), a damage‐associated molecular pattern (DAMP) produced by cellular injury, contributes to neutrophil activation/inflammation in trauma patients and arises in cancer and autoimmunity. To further understand relationships between cf‐mDNA released by tissue injury, inflammation, and health benefits of exercise, we examined cf‐mDNA response to prolonged moderate aerobic exercise. Seven healthy moderately trained young men (age = 22.4 ± 1.2) completed a treadmill exercise trial for 90 min at 60% VO 2 max and a resting control trial. Blood was sampled immediately prior to exercise (0 min = baseline), during (+18, +54 min), immediately after (+90 min), and after recovery (R40). Plasma was analyzed for cf‐mDNA, IL‐6, and lactate. A significant difference in cf‐mDNA response was observed between exercise and control trials, with cf‐mDNA levels reduced during exercise at +54 and +90 (with or without plasma volume shift correction). Declines in cf‐mDNA were accompanied by increased lactate and followed by an increase in IL‐6, suggesting a temporal association with muscle stress and inflammatory processes. Our novel finding of cf‐mDNA decline with prolonged moderate treadmill exercise provides evidence for increased clearance from or reduced release of cf‐mDNA into the blood with prolonged exercise. These studies contrast with previous investigations involving exhaustive short‐term treadmill exercise, in which no change in cf‐mDNA levels were reported, and contribute to our understanding of differences between exercise‐ and trauma‐induced inflammation. We propose that transient declines in cf‐mDNA may induce health benefits, by reducing systemic inflammation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Human Subjectsmentioning

confidence: 99%

Section: Preliminary Trialsmentioning

confidence: 99%

Section: Blood Sample Processingmentioning

confidence: 99%

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Plasma cell-free mitochondrial DNA declines in response to prolonged moderate aerobic exercise

et al. 2016

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No effect of menstrual cycle phase on glucose and glucoregulatory endocrine responses to prolonged exercise

et al. 2013

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Effects of prolonged exercise on agouti-related protein: a pilot study

Castracane¹,

Francois

Ghanbari–Niaki³

et al. 2012

Endocrine

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Agouti-related protein (AgRP), is a signaling peptide that affects feeding behavior, energy homeostasis, and has also been shown to stimulate the hypothalamic-pituitary-adrenal axis. The purpose of this study was to determine the effects of 90 min of treadmill exercise on circulating AgRP concentrations and the relationship of AgRP responses to cortisol. Seven young males completed a preliminary trial followed by counterbalanced experimental and control trials 4-5 weeks apart. The experimental trial began 2.5 h after consumption of a standard nutrient beverage and consisted of treadmill exercise at 60 % of previously determined VO(2max) for 90 min. Blood samples were collected before (-30 and 0 min), during (18, 36, 54, 72, and 90 min), and following exercise (20, 40, and 60 min). Blood samples were collected in a resting, control trial at the same time points as the experimental trial. Plasma lactate was significantly higher in the exercise than the control trial. Although AgRP increased from 18 min of exercise to peak at 90 min, these increases were not significantly different than values in the control trial. Cortisol responses during the exercise trial were significantly higher than the control trial. AgRP concentrations during early exercise were positively correlated with cortisol levels later in recovery. The obtained data suggest that AgRP concentrations during prolonged steady-state exercise are associated with subsequent cortisol increases, but further study is required to determine whether there is a causal effect.

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Amylin and Selective Glucoregulatory Peptide Alterations during Prolonged Exercise

Abstract: In a postprandial state, prolonged exercise stimulates glucagon and cortisol increases that are associated with stable blood glucose and leptin concentrations; however, similar to postprandial state control condition, insulin, C-peptide, and amylin concentrations decline.

Cited by 14 publications

References 31 publications

Plasma cell-free mitochondrial DNA declines in response to prolonged moderate aerobic exercise

Plasma cell-free mitochondrial DNA declines in response to prolonged moderate aerobic exercise

No effect of menstrual cycle phase on glucose and glucoregulatory endocrine responses to prolonged exercise

Effects of prolonged exercise on agouti-related protein: a pilot study

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