Amylin and glucose co-activate area postrema neurons of the rat

Riediger, Thomas; Schmid, Herbert; Lutz, Thomas; Simón, E.

doi:10.1016/s0304-3940(02)00482-2

Cited by 60 publications

(52 citation statements)

References 21 publications

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“…The AP also seems to be necessary for amylin's action to inhibit gastric emptying (Young et al, 1995;Gedulin et al, 1997;Wickbom et al, 2008;Mack et al, 2010;Young, 2005b). Electrophysiological and immunohistochemical studies supported a direct influence of amylin on the AP (Riediger et al, , 2002Potes et al, 2010bPotes et al, , 2012. As discussed in section III of this article, the receptor components (calcitonin receptor, RAMPs) necessary for amylin function appear to be expressed in the AP.…”

Section: A Amylin Action In the Brainstemmentioning

confidence: 54%

Amylin: Pharmacology, Physiology, and Clinical Potential

Hay¹,

Chen²,

Lutz³

et al. 2015

Pharmacol Rev

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Section: A Amylin Action In the Brainstemmentioning

confidence: 54%

Amylin: Pharmacology, Physiology, and Clinical Potential

Hay¹,

Chen²,

Lutz³

et al. 2015

Pharmacol Rev

Self Cite

291

297

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“…Numerous papers clearly establish the AP as an important amylinresponsive site Mollet et al, 2004;Potes et al, 2010;Riediger et al, 2002), especially for shortterm effects on food intake (Lutz et al, 1994(Lutz et al, , 1995b. Indeed, AP lesions (Lutz et al, 1998) and intra-AP amylin receptor antagonist administration (Mollet et al, 2004) have provided data that establish the AP as a physiologically relevant site of action for amylin-mediated effects on food intake.…”

Section: Discussionmentioning

confidence: 99%

“…Although the vast majority of reports suggest that the anorectic and BW-suppressive effects of amylin receptor activation are mediated primarily by the area postrema (AP; Lutz et al, 1998;Mollet et al, 2004;Riediger et al, 2002), a hindbrain circumventricular nucleus, the food intake-regulatory effects of amylin receptor signaling at other brain nuclei are largely unexplored. This is surprising considering the widespread distribution of central nervous system (CNS) sites that bind amylin or sCT (Beaumont et al, 1993;Christopoulos et al, 1995;Paxinos et al, 2004;Sexton et al, 1994) and the fact that amylin readily crosses the blood-brain barrier (Banks et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

Mietlicki‐Baase

Rupprecht

Olivos

et al. 2013

Neuropsychopharmacol

116

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The ability of amylin, a pancreatic b-cell-derived neuropeptide, to promote negative energy balance has been ascribed to neural activation at the area postrema. However, despite amylin binding throughout the brain, the possible role of amylin signaling at other nuclei in the control of food intake has been largely neglected. We show that mRNA for all components of the amylin receptor complex is expressed in the ventral tegmental area (VTA), a mesolimbic structure mediating food intake and reward. Direct activation of VTA amylin receptors reduces the intake of chow and palatable sucrose solution in rats. This effect is mediated by reductions in meal size and is not due to nausea/malaise or prolonged suppression of locomotor activity. VTA amylin receptor activation also reduces sucrose selfadministration on a progressive ratio schedule. Finally, antagonist studies provide novel evidence that VTA amylin receptor blockade increases food intake and attenuates the intake-suppressive effects of a peripherally administered amylin analog, suggesting that amylin receptor signaling in the VTA is physiologically relevant for food intake control and potentially clinically relevant for the treatment of obesity.

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“…Extracellular recordings from both the SFO 43 and AP 44 showed that amylin caused concentration-related increases in the activity of neurons in both of these CVOs. Interestingly, in the AP, at least a proportion of the neurons responsive to amylin were also glucose responsive.…”

Section: Amylin and Ghrelinmentioning

confidence: 98%

“…Interestingly, in the AP, at least a proportion of the neurons responsive to amylin were also glucose responsive. 44 We have recently used dissociated cell techniques combined with patch-clamp recording to examine, at the singlecell level, the mechanisms through which amylin influences the excitability of SFO neurons. 21 Our studies confirm the earlier study of Reidiger et al 43 demonstrating clear depolarizing effects of amylin on SFO neurons, which were concentration dependent with a minimal effective concentration of 10 pM (Figure 2).…”

Section: Amylin and Ghrelinmentioning

confidence: 99%

Gastrointestinal hormone actions in the central regulation of energy metabolism: potential sensory roles for the circumventricular organs

2009

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A variety of circulating signals provide essential information to the central nervous system (CNS) regarding nutritional status. The gastrointestinal system produces many such molecules that are now known to have profound effects on feeding behavior and the control of metabolism as a consequence of their ability to regulate the neural circuitry involved in metabolic homeostasis. Although many of these substances have been suggested to directly access such brain centers, their lipophobic characteristics suggest that alternative mechanisms should be considered. In this paper, we consider one such alternative, namely, that a specialized group of CNS structures collectively known as the sensory circumventricular organs (CVOs), which are not protected by the normal blood-brain barrier, may play important roles in such blood to brain communications. Specifically, we review a developing literature that shows receptors for, and functional actions of, gastrointestinal hormones such as amylin, cholecystokinin, ghrelin and peptide YY in the area postrema and subfornical organ. Collectively, these observations suggest potentially significant roles for the sensory CVOs in the regulation of energy balance.

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Amylin and glucose co-activate area postrema neurons of the rat

Cited by 60 publications

References 21 publications

Amylin: Pharmacology, Physiology, and Clinical Potential

Amylin: Pharmacology, Physiology, and Clinical Potential

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

Gastrointestinal hormone actions in the central regulation of energy metabolism: potential sensory roles for the circumventricular organs

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