Amylase crystalloids in salivary gland lesions: Report of a case with a review of the literature

López‐Ríos, Fernando; Díaz-Bustamante, Teresa; Serrano-Egea, A.; Jimenez, J. M. Santolaya; Agustín, Pedro de

doi:10.1002/dc.2003

“…Moreover, amylase crystalloids can measure up to 500 μm whereas intraluminal crystalloids only measure up to 100 μm (19,20). Crystalloids observed in our study were morphologically similar to α-amylase crystalloids described in the literature (3)(4)(5)(6)(7)(8).…”

Section: Dıscussıonsupporting

confidence: 79%

The role of cd56, hbme-1, and p63 in follicular neoplasms of the thyroid

Etem¹,

Özekinci²,

Mızrak³

et al. 2010

TJPATH

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Amylase crystalloids is one of the several types of crystalline structures that can be seen in non-neoplastic and neoplastic salivary gland lesions. Here, a 60-year-old woman with an infraauricular mass existing for two years is presented. On ultrasound a cystic mass, 1 cm in diameter was detected in the tail of right parotid gland. Clear and mucoid fluid was obtained from the mass by fine-needle aspiration. Smears showed numerous rhomboid, rectangular or rod-shaped, non-birefringent crystalloid structures and a few acinar cell groups in a mucoid background rich in polymorphonuclear leucocytes and lymphoctes. It was reported as cystic sialadenitis with amylase crystalloids. In the four-month follow-up, there was no recurrence of the mass.

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“…Moreover, amylase crystalloids can measure up to 500 μm whereas intraluminal crystalloids only measure up to 100 μm (19,20). Crystalloids observed in our study were morphologically similar to α-amylase crystalloids described in the literature (3)(4)(5)(6)(7)(8).…”

Section: Dıscussıonsupporting

confidence: 79%

“…There are many types of crystalline structures such as amylase, tyrosine, collagenous crystalloids, oxalate and intraluminal crystals that can be seen in FNA smears of salivary gland lesions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). It is important to differentiate other types of crystalloids from amylase crystalloids because they can be seen in malignant salivary gland tumors whereas amylase crystalloids are not (9,17,18).…”

Section: Dıscussıonmentioning

confidence: 99%

Amylase crystalloids on fine-needle aspiration of the salivary gland

Paker¹,

Anlar²,

Genel³

et al. 2010

TJPATH

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Amylase crystalloids is one of the several types of crystalline structures that can be seen in non-neoplastic and neoplastic salivary gland lesions. Here, a 60-year-old woman with an infraauricular mass existing for two years is presented. On ultrasound a cystic mass, 1 cm in diameter was detected in the tail of right parotid gland. Clear and mucoid fluid was obtained from the mass by fine-needle aspiration. Smears showed numerous rhomboid, rectangular or rod-shaped, non-birefringent crystalloid structures and a few acinar cell groups in a mucoid background rich in polymorphonuclear leucocytes and lymphoctes. It was reported as cystic sialadenitis with amylase crystalloids. In the four-month follow-up, there was no recurrence of the mass.Since encountered only in benign salivary gland lesions in the literature as in our case, observation of amylase crystalloids on fine-needle aspiration smears indicates a benign lesion and avoids unnecessary surgery.

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“…Tyrosine-rich crystalloids are occasionally found in the stroma of benign (e.g., pleomorphic adenoma) and malignant (e.g., polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma) salivary gland neoplasms, as well as in the lumen of nonneoplastic parotid gland cysts [6,14,15]. On the other hand, nontyrosine crystalloids have been observed only in benign and reactive salivary gland lesions, such as sialadenitis with sialolithiasis, lymphoepithelial cyst, pleomorphic adenoma, oncocytic cystadenoma, Warthin's tumor, and benign parotid gland cysts [6,[16][17][18]. Collagenous crystalloids have been described in association with both benign and malignant neoplasms, including pleomorphic adenomas, myoepitheliomas, and myoepithelial carcinoma, respectively [9,19].…”

Section: Discussionmentioning

confidence: 99%

Salivary Oncocytic Cystadenoma with Intraluminal Crystalloids: a Case Report with Review of the Literature

Bežić

¹

,

Glavina-Durdov

²

2011

Head and Neck Pathol

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Oncocytic cystadenoma is a rare benign tumor of major salivary glands that in rare occasions may present histologically with intraluminal crystalloids. We report a case of 53-year-old man with a progressively enlarging lump in the left submandibular region. Ultrasound examination revealed a cystic mass with an intraluminal fluid collection. The tumor was surgically removed. Histologic examination yielded a diagnosis of oncocytic cystadenoma with a high concentration of intraluminal crystalloids. The microscopic features of the crystalloids were compatible with nontyrosine (alpha-amylase) crystalloids. When compared with previously published cases in the literature, this is the first report of oncocytic cystadenoma with intraluminal crystalloids arising in the submandibular gland, and the second reported case of the nontyrosine type of crystalloids occurring in association with this tumor. The nontyrosine crystalloids may be highly characteristic to salivary gland tumors with oncocytic differentiation.

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Amylase crystalloids in salivary gland lesions: Report of a case with a review of the literature

Cited by 24 publications

References 16 publications

The role of cd56, hbme-1, and p63 in follicular neoplasms of the thyroid

The role of cd56, hbme-1, and p63 in follicular neoplasms of the thyroid

Amylase crystalloids on fine-needle aspiration of the salivary gland

Salivary Oncocytic Cystadenoma with Intraluminal Crystalloids: a Case Report with Review of the Literature

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