Amygdalostriatal coupling underpins positive but not negative coloring of ambiguous affect

Kim, M. Justin; Mattek, Alison M.; Shin, Jin

doi:10.1101/811505

Cited by 3 publications

(3 citation statements)

References 57 publications

(24 reference statements)

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“…This result is supported by a meta-analysis study demonstrating an inverse relationship between positive affect and pain severity in people with chronic non-cancer pain. 63 We think that the NAc-amygdala network, which underpins positive emotional valence, 64 might play a role in buffering or facilitating clinical pain. However, how the dopaminergic neurotransmission through the reward circuitry influences migraine pain requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Kim¹,

Jassar²,

Lim³

et al. 2021

JPR

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Purpose It has been suggested that reward system dysfunction may account for emotion and pain suffering in migraine. However, there is a lack of evidence whether the altered reward system connectivity is directly associated with clinical manifestations, including negative affect and ictal pain severity and, at the molecular level, the dopamine (DA) D2/D3 receptors (D2/3Rs) signaling implicated in encoding motivational and emotional cues. Patients and Methods We acquired resting-state functional MRI from interictal episodic migraine (EM) patients and age-matched healthy controls, as well as positron emission tomography (PET) with [ 11 C]raclopride, a selective radiotracer for DA D2/3Rs, from a subset of these participants. The nucleus accumbens (NAc) was seeded to measure functional connectivity (FC) and DA D2/3Rs availability based on its essential involvement in pain-related aversive/reward functions. Associations of the brain measures with positive/negative affect and ictal pain severity were also assessed. Results Compared with controls, the EM group showed weaker right NAc connectivity with areas implicated in pain and emotional regulation, such as the amygdala, rostral anterior cingulate cortex, hippocampus, and thalamus; but showed stronger left NAc connectivity with the dorsolateral prefrontal cortex and lingual gyrus. Moreover, among the altered NAc connectivities, only right NAc-amygdala connectivity was inversely correlated with DA D2/3Rs availability in migraine patients (diagnostic group-by-D2/3Rs interaction p < 0.007). At a clinical level, such weaker NAc-amygdala connectivity was associated with lower interictal positive affect and greater ictal pain severity over the head and facial extension area (pain area and intensity number summation, PAINS). Conclusion Together, our findings suggest that altered reward system connectivity, specifically between the NAc and amygdala, might be affected by endogenous DA D2/3Rs signaling, and such process might be a neural mechanism that underlies emotional and pain suffering in episodic migraineurs.

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Section: Discussionmentioning

confidence: 99%

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Kim¹,

Jassar²,

Lim³

et al. 2021

JPR

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“…Also, since the task required a tripartite (positive/neutral/negative) categorization (Rosen et al, 2004;Fernandez-Duque and Black, 2005;Kipps et al, 2009), and considering the relatively low number of trials per emotion and the need guarantee adequate signal-to noise ratios for EEG data, different negative emotions (anger, disgust, fear, sadness) were not assessed individually. Moreover, the valence of 'surprise' may prove ambiguous, prompting both positive and negative interpretations (Kim et al, 2017;Petro et al, 2018;Kim et al, 2020b). Future tasks could tackle these shortcomings and provide more finegrained results for each emotion individually.…”

Section: Limitations and Further Researchmentioning

confidence: 99%

Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration

et al. 2021

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Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-Intero and post-Extero facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-Intero negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only BvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-Intero negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-Intero negative FER correlated with the volume of the insula and the anterior cingulate cortex. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-Intero condition, and along the (b) executive network in the post-Extero condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively.Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of interoception, emotion, allostasis, and neurodegeneration.

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“…SU was related to decreased VS-dmPFC connectivity for social rewards, potentially suggesting that increased SU is related to altered ability to process social information. Striatal connectivity has been linked to interpreting others’ facial expressions (Kim et al, 2020), and the dmPFC has been implicated in social cognitive functions during receipt of social feedback (e.g., Ferrari et al, 2016) and prediction error during social learning (Joiner et al, 2017; Suzuki et al, 2012). Reduced correspondence of the VS with dmPFC during social reward may suggest an impaired facility for assessing and reacting to feedback from others.…”

Section: Discussionmentioning

confidence: 99%

Corticostriatal Responses to Social Reward are Linked to Trait Reward Sensitivity and Subclinical Substance Use in Young Adults

Wyngaarden

Johnston

Sazhin

et al. 2023

Preprint

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Substance use (SU) has been linked to alterations in reward processing in the ventral striatum (VS). However, less is known about how SU relates to striatal activation and connectivity during social rewards (e.g., positive peer feedback). In this pre-registered study, we hypothesized that SU would be associated with activation and functional connectivity of the VS during receipt of social rewards. Participants (N=44) underwent two fMRI tasks to isolate neural response to social and monetary rewards. The tasks involved choosing between two stimuli: either two purported peers, with the goal of identifying the peer who liked the participant (social); or two doors, with the goal of identifying the door containing a $0.50 prize (monetary). We predicted that VS activation in response to social rewards would be correlated with SU, independent of reward sensitivity (RS); however, an exploratory whole-brain analysis revealed SU was related to activation in the temporoparietal junction instead. Moreover, results showed that aberrant RS blunts the relationship between SU and striatal activation during receipt of rewards, regardless of their domain. Psychophysiological interaction (PPI) analysis demonstrated that SU was associated with decreased connectivity between the VS and dorsomedial prefrontal cortex for social rewards, independent of RS. Exploratory analyses further revealed that RS is associated with increased connectivity between the VS and ventromedial prefrontal cortex during social rewards. Taken together, these findings shed light on the relationships between potential risk factors for developing substance use disorder.

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Amygdalostriatal coupling underpins positive but not negative coloring of ambiguous affect

Cited by 3 publications

References 57 publications

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration

Corticostriatal Responses to Social Reward are Linked to Trait Reward Sensitivity and Subclinical Substance Use in Young Adults

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