Amygdaloid and Hippocampal β‐Adrenoceptors in the Olfactory Bulbectomy Syndrome: Effects of Desipramine

Richardson, Steven; Tiong, A. H. K.

doi:10.1111/j.1749-6632.1999.tb09319.x

Cited by 4 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has long been known that the downregulation of brain b-noradrenergic receptors follows chronic, but not acute, exposure to antidepressant drugs (Vetulani and Sulser, 1975) and is a common consequence of the chronic administration of all clinically effective antidepressant drug treatments (Jesberger and Richardson, 1985). The functional and mechanistic connections between the ability of chronic antidepressant drugs to downregulate hippocampal badrenergic receptors (Richardson and Tiong, 1999) and to upregulate hippocampal BDNF (the present study) remain to be investigated.…”

Section: Discussionmentioning

confidence: 98%

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Richardson

2003

Neuropsychopharmacol

157

View full text Add to dashboard Cite

It has been proposed that antidepressants have neuroprotective effects on hippocampal neurons. To further test this hypothesis, brainderived neurotrophic factor (BDNF), B cell lymphoma protein-2 (Bcl-2), and copper-zinc superoxide dismutase (Cu/Zn-SOD) were examined immunohistochemically in hippocampal neurons of Sprague-Dawley rats following daily treatment with 5 or 10 mg/kg of amitriptyline or venlafaxine for 21 days. At 5 mg/kg, both amitriptyline and venlafaxine increased the intensity of BDNF immunostaining in hippocampal pyramidal neurons, and the intensity of Bcl-2 immunostaining in hippocampal mossy fibers, but did not alter the Cu/Zn-SOD immunoreactivity. The high dose of venlafaxine, however, decreased the intensity of BDNF immunostaining in all subareas of the hippocampus and increased the intensity of Cu/Zn-SOD immunostaining in the dentate granular cell layer. The high dose of amitriptyline increased the intensity of Cu/Zn-SOD immunostaining, but did not affect the immunoreactivity of Bcl-2 or BDNF. These findings suggest that the chronic administration of amitriptyline or venlafaxine at 5 mg/kg, but not 10 mg/kg, may be neuroprotective to hippocampal neurons. These dose-related effects of antidepressant drugs on hippocampal neurons may have relevance to disparate findings in the field.

show abstract

Section: Discussionmentioning

confidence: 98%

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Richardson

2003

Neuropsychopharmacol

157

View full text Add to dashboard Cite

show abstract

“…As several reports have linked olfactory bulbectomy to changes in the amygdala and hippocampus (Richardson and Tiong, 1999, elevated density of b-adrenoceptors in the amygdala and hippocampus; Wrynn et al, 2000, decreased MRI signal in the amygdala, indicating an altered tissue volume, pronounced enlargement of the lateral ventricle with impaired hippocampal function as a consequence; Rutkoski et al, 2002, significant increase in neuropeptide Y expression in the amygdala; Watanabe et al, 2003, increased serotonin synthesis in the hippocampus), we selected the two brain areas for this study. Moreover, the hippocampus and amygdala besides the anterior cingulate and the prefrontal cortex are included into the key neural circuit of depression (Henn and Vollmayr, 2004b;Sapolsky, 2004).…”

Section: Introductionmentioning

confidence: 99%

Cell Proliferation is Influenced by Bulbectomy and Normalized by Imipramine Treatment in a Region-Specific Manner

Keilhoff

Becker

Grecksch

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Growing evidence indicates that alterations of neuroplasticity may contribute to the pathophysiology of depression. In contrast, various antidepressants increase adult hippocampal neurogenesis and block the effects of stress. These findings result in the 'neurogenesis hypothesis of depression'. The present study seeks to determine out whether cell proliferation is altered in the hippocampus, subventricular zone (SVZ), and basolateral amygdala of adult rats exposed to bilateral olfactory bulbectomy, another established model of depression and, if so, how imipramine effects bulbectomy-induced changes of cell genesis. Bulbectomy results in a significant reduction of cell proliferation in the hippocampus and SVZ, an effect that is normalized by subchronic doses of imipramine. Moreover, an increase in cell genesis in the basolateral amygdala, which is not affected by imipramine, is demonstrated. TUNEL staining indicates an enhanced apoptosis after bulbectomy in the SVZ that cannot be reduced by imipramine. Cell death rates in the hippocampus and amygdala are not affected by bulbectomy. The opposing effects of bulbectomy and imipramine treatment in the hippocampus and amygdala demonstrate that these structures of the limbic system, both integrated in emotional processing, react quite differently with regard to neuroplasticity. Further to this, we discuss a possible link between the pathogenesis of depression and changed neuronal plasticity in the SVZ.

show abstract

Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models

Louis

Stemmelin

Boulay

et al. 2008

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Amygdaloid and Hippocampal β‐Adrenoceptors in the Olfactory Bulbectomy Syndrome: Effects of Desipramine

Cited by 4 publications

References 13 publications

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Cell Proliferation is Influenced by Bulbectomy and Normalized by Imipramine Treatment in a Region-Specific Manner

Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models

Contact Info

Product

Resources

About