Amygdalin Enhances the Antitumor Effect of Sorafenib

Elmetwalli, Alaa; Khalek, Aya M. Abdel; El‐Naggar, Sabry A.; El-Magd, Mohammed Abu; Salama, Afrah F.

doi:10.21608/eajbsd.2021.196336

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Natural products (NPs) represent available sources for developing new anticancer agents (6). In addition, NPs have antioxidant effects that can eliminate free radicals (7). NPs can also reduce or minimize the toxic side effects of chemotherapy (8).…”

Section: Introductionmentioning

confidence: 99%

Parotoid gland secretions of the Egyptian toad (Bufo relgularis): In vivo antitumor effect on Ehrlich ascites carcinoma bearing mice

El‐Naggar

Basyony²,

El-Feki³

et al. 2023

Journal of Bioscience and Applied Research

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Background: Parotoid gland secretions (PGS) contain several bioactive compounds with potential applications for drug development. Objective: This study was conducted to evaluate the in vivo antitumor effect of PGS collected from the Egyptian toad, Bufo relgularis using Ehrlich ascites carcinoma-bearing mice (EAC). Methods:The median lethal dose (LD50) of PGS was determined, then forty CD-1 female mice were divided into 4 groups (n=10) as follows: Group (Gp1) served as a negative control. Gp2-Gp4 had inoculated intraperitoneally (i.p) with 1×10 6 EAC cells/mouse. Then, Gp2 was left as a positive control (EAC-bearing mice). After 24 hours, Gp3 had injected i.p with Cisplatin (Cis) (2 mg/kg) on day 1 for 7 consecutive days. Gp4 had injected with 1/10 LD50 of PGS (7.85 mg/kg, b.wt) i.p for 7 consecutive days. All groups were sacrificed on day 14 to collect blood samples.The percentages of total body weight (% bwt) change, tumor volume, and total tumor cell counts were determined.Alanine and aspartate transaminases (ALT and AST), antioxidant /oxidant biomarkers (SOD, CAT, and MDA), and histological investigations of liver tissues were evaluated. Results: The results showed that the % b.wt changes were increased in EAC-bearing mice, while the treatment of EAC-bearing mice with PGS decreased its % b.wt changes. The treatment of EAC-bearing mice with PGS decreased the tumor volume and its counts. PGS treatment led to an improvement in AST, ALT, and antioxidant enzyme activities, and ameliorated the histopathological changes in the liver induced by EAC inoculation. Conclusion: We concluded that PGS had a potential anticancer effect against EAC-bearing mice.

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Section: Introductionmentioning

confidence: 99%

Parotoid gland secretions of the Egyptian toad (Bufo relgularis): In vivo antitumor effect on Ehrlich ascites carcinoma bearing mice

El‐Naggar

Basyony²,

El-Feki³

et al. 2023

Journal of Bioscience and Applied Research

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“…The resultant chromogen's absorbance was measured at 405 nm, and it was shown to be directly associated with the GSH content. Thiobarbituric acid reacted with malondialdehyde (MDA), a marker of lipid peroxidation, to determine its presence in plasma and tissues [17].…”

Section: Oxidative Stress Assessmentmentioning

confidence: 99%

Assessment of Histological Damage to Rat Liver Induced by Gold Nanoparticles Derived from Bacteria: Preliminary Investigation on Dose-Dependent Effects

G. Abd Elnasser,

Elmetwalli,

A. Hamed

et al. 2024

Benha Journal of Applied Sciences

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Background: Gold nanoparticles (GNPs) have garnered considerable attention in various biomedical applications due to their unique physicochemical properties. Understanding the dose-dependent histological effects of GNPs on liver tissue in animal models is crucial for evaluating their safety profile and optimizing their therapeutic applications. This study aimed to evaluate the hepatotoxicity of bacterially derived GNP on rat liver for proceeding into a further study. Material and Methods: Male Wistar rats were divided into four groups: control, 25, 50, 100, and 200 mg/kg GNP, and the rats were given a 15-day acclimatization period. The rats were subjected to lipid peroxidation, oxidative stress, and liver histology tests. Results: The levels of ALT, AST, and albumin significantly differed from the control group (P<0.001), as revealed in Fig. 1. The results revealed that the rats treated with 50 mg/Kg GNPs had the most beneficial effects, while GSH levels were higher in the group treated with 100 mg/GNPs than in the groups treated with 20 mg/L GNPs. In addition, GNPs-treated rats showed an increase in inflammation in the liver, with the presence of inflammatory cells. Conclusion: These findings emphasize the importance of thorough safety evaluations in GNPs for proceeding the coming research.

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“…To assess their function in controlling oxidative stress in vivo, two redox parameters-reactive oxygen species (ROS) [14], glutathione-S-transferase (GST), and malondialdehyde (MDA) [15]-were chosen. Using the sulfosalicylic acid and DTNB techniques, the absorbance of the reaction mixture was measured at 412 nm in order to quantify the amounts of GST.…”

Section: Measurement Of Redox Parametersmentioning

confidence: 99%

Chitosan-doped gold nanoparticles with potent and selective activity against diabetes mellitus

.Elmetwalli,

. G. Hassan,

Ashraf

et al. 2024

Benha Journal of Applied Sciences

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Background: Diabetes Mellitus (DM) poses a significant global health challenge, with rising prevalence and associated complications. Despite available treatments, the search for safer and more effective options continues. This study investigates the potential of chitosan-doped gold nanoparticles (AuNPs-chito) as a novel therapeutic approach for DM. Chitosan shows promise as a flexible biomolecule for the management of several pathophysiological problems linked to diabetes mellitus (DM) because of its dual roles as an antidiabetic agent and medication carrierMethods: Streptozotocin-induced diabetic rats were treated with AuNPs-chito, and various biochemical and histopathological parameters were assessed.Results: Our data indicate that AuNPs-Chito administration led to significant improvements in blood glucose levels, lipid profiles, oxidative stress markers, and liver function compared to untreated diabetic rats. Histopathological examination revealed restoration of hepatic architecture in AuNPs-chito-treated rats. Conclusion: These findings suggest that AuNPs-chito may offer a promising strategy for managing DM by mitigating oxidative stress and improving metabolic parameters.

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Amygdalin Enhances the Antitumor Effect of Sorafenib

Cited by 4 publications

References 3 publications

Parotoid gland secretions of the Egyptian toad (Bufo relgularis): In vivo antitumor effect on Ehrlich ascites carcinoma bearing mice

Parotoid gland secretions of the Egyptian toad (Bufo relgularis): In vivo antitumor effect on Ehrlich ascites carcinoma bearing mice

Assessment of Histological Damage to Rat Liver Induced by Gold Nanoparticles Derived from Bacteria: Preliminary Investigation on Dose-Dependent Effects

Chitosan-doped gold nanoparticles with potent and selective activity against diabetes mellitus

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