Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging

Massana, Guillem; Serra-Grabulosa, Josep M.; Salgado‐Pineda, Pilar; Gastó, Cristòbal; Junqué, Carme; Massana, Joan; Mercader, J.M.; Gómez, Beatriz; Tobeña, Adolf; Salamero, Manel

doi:10.1016/s1053-8119(03)00036-3

Cited by 154 publications

(86 citation statements)

References 55 publications

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“…Later, Uchida et al, using the same a priori hypothesis, detected a reduction of the left temporal lobe in 11 patients with PD compared to 11 controls. 68 The absence of abnormalities of the temporal lobe in the study by Massana et al 67 in contrast to the study by Uchida 68 and to previous literature 66 may be attributed to a highly conservative measurement of the ROI, centered only on the medial segment and excluding the volumes of the hippocampus and amygdala.…”

Section: -52mentioning

confidence: 59%

“…63 Massana et al evaluated the amygdala, temporal lobe and hippocampus of 12 patients with PD compared to 12 healthy controls. 67 This was the first study to determine the volume of the amygdala in PD patients, with the observation of a significant bilateral reduction of this region compared to controls. Later, Uchida et al, using the same a priori hypothesis, detected a reduction of the left temporal lobe in 11 patients with PD compared to 11 controls.…”

Section: -52mentioning

confidence: 99%

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Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

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Objective: The aim of the present report is to present a systematic and critical review of the more recent literature data about structural abnormalities detected by magnetic ressonance in anxiety disorders. Method: A review of the literature in the last five years was conducted by a search of the Medline, Lilacs and SciELO indexing services using the following key words : "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" and "obsessive-compulsive", crossed one by one with "magnetic resonance", "voxel-based", "ROI" and "morphometry palavras-chave: "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" e "obsessive-compulsive" cruzadas uma a uma com "magnetic ressonance", "voxel-based", "ROI" e "morphometry

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Section: -52mentioning

confidence: 59%

Section: -52mentioning

confidence: 99%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

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“…The amygdala has several functions in emotional behavior and fear conditioning, and a smaller amygdala is reported in anxiety disorders. [51][52][53][54] One may speculate that a smaller amygdala is the structural link between recently reported associations of polymorphisms in the ERa gene and anxiety. 51,52,55 Future studies should include both amygdala volume and psychometric assessments of anxiety to test this hypothesis.…”

Section: Discussionmentioning

confidence: 95%

Variations in estrogen receptor α gene and risk of dementia, and brain volumes on MRI

et al. 2004

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The role of estrogens in Alzheimer's disease (AD) is controversial. We investigated the association between well-recognized, and potentially functional, polymorphisms in the estrogen receptor (ER) a gene and the risk of AD in a prospective study of 6056 Caucasian older men and women aged 55 years and over. In a subset of 468 participants, we assessed volumes of the hippocampus and amygdala, which have a high density of ERa, with brain magnetic resonance imaging (MRI) (1.5 T MR unit). During a total of 35 405 person-years of follow-up (mean per persons 5.8 years), 312 new cases of dementia were detected, of whom 230 were diagnosed with AD. Neither the PvuII nor the XbaI polymorphism or haplotypes thereof were associated with the risk of all-cause dementia or AD. In contrast, we found that nondemented women who carried the PvuII p allele or haplotype 'px' had smaller amygdalar volumes on MRI in an allele-dose-dependent fashion. Total amygdalar volume was 4.50 (SE 0.10) in PP genotype, 4.45 (SE 0.06) in Pp genotype, and 4.18 ml (SE 0.08) in pp genotype (P trend ¼ 0.008). Further studies are required to investigate whether this smaller amygdalar volume has functional significance.

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“…Reduced volume of temporal lobe was detected in other studies (Fontaine et al, 1990;Ontiveros et al, 1989;Vythilingam et al, 2000). However, Massana et al (2003) didn´t find any changes in temporal lobe (probably because of excluding hippocampus and amygdala in his Region of Interest investigations). There is an evidence of a dysfunction in hippocampus, amygdala, cingulated gyrus revealed in functional magnetic resonance imaging (Bystritsky et al, 2001).…”

Section: Neuroimaging Results In Separation Anxiety Disorder In Childrenmentioning

confidence: 65%

Separation Anxiety in Children and Adolescents

Dąbkowska¹,

Araszkiewicz²,

Dabkowska³

et al. 2011

Different Views of Anxiety Disorders

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Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging

Cited by 154 publications

References 55 publications

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Variations in estrogen receptor α gene and risk of dementia, and brain volumes on MRI

Separation Anxiety in Children and Adolescents

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