Amygdala sensitivity for negative information as a neural marker for negative memory bias across psychiatric diagnoses

Duyser, Fleur; Vrijsen, Janna N.; Oort, Jasper van; Collard, Rose M.; Schene, Aart H.; Tendolkar, Indira; Eijndhoven, Philip F. van

doi:10.1016/j.pscychresns.2022.111481

Cited by 4 publications

(9 citation statements)

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“…Single-subject parameter estimates for the faces vs. shapes contrast, indicating regions of increased activity for the faces relative to the shapes, were obtained in a first-level analysis by means of a one-sample t-test. As an indicator of reactivity to negative emotional information, parameter estimates (beta weights) for the faces vs. shapes contrast were extracted from the left and right amygdala by using the MarsBaR toolbox with regions of interest from the Automatic Anatomical Labeling (AAL) atlas [57, 58].…”

Section: Executive Control Measuresmentioning

confidence: 99%

“…1.0 × 1.0 × 1.0 mm, flip angle: 8°, GRAPPA acceleration factor: 2). [57] Pre-processing and first-and second-level analysis of the fMRI data were carried out in SPM12…”

Section: Amygdala Reactivity Measured By the Emotional Faces Processi...mentioning

confidence: 99%

“…Participants completed two ‘face’ and three ‘shape’ blocks that consisted of six trials of 30s each. The fMRI data acquisition settings during the emotional faces processing task have previously been described in a different publication from the MIND-Set study [57]:…”

Section: Executive Control Measuresmentioning

confidence: 99%

“…Anatomical images were acquired using a T1-weighted MP-RAGE sequence (TR = 2300 ms, TE = 3.03 ms, voxel size: 1.0 × 1.0 × 1.0 mm, flip angle: 8°, GRAPPA acceleration factor: 2). [57]…”

Section: Executive Control Measuresmentioning

confidence: 99%

“…Pre-processing and first- and second-level analysis of the fMRI data were carried out in SPM12 (Wellcome Department of Imaging Neuroscience, London, United Kingdom). A detailed description of the pre-processing parameters can be found in previous work by Duyser and colleagues [57]. Single-subject parameter estimates for the faces vs. shapes contrast, indicating regions of increased activity for the faces relative to the shapes, were obtained in a first-level analysis by means of a one-sample t-test.…”

Section: Executive Control Measuresmentioning

confidence: 99%

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How executive control and emotional reactivity influence coping strategies in psychiatric patients during the COVID-19 pandemic

Kist,

Schlüter,

Duyser

et al. 2024

Preprint

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BackgroundDuring times of environmental challenges, adaptive coping strategies are essential to maintain mental health. Coping relies on executive control, which is often impaired in individuals with psychiatric disorders. Furthermore, emotional reactivity may interfere with executive control. Studying the association between cognitive skills and adaptive coping strategies, as well as the potential impact of emotional reactivity, could inform how we can provide mental support during large-scale adversity. In this study we examined coping strategies in a thoroughly phenotyped psychiatric cohort, the MIND-Set cohort, during the early COVID-19 pandemic stage.MethodsWe studied 1) the association between coping and both subjective and objective executive control before the pandemic, and three different coping strategies used during the pandemic, 2) the mediating role of emotional reactivity, indexed by amygdala reactivity, and 3) the moderating role of the presence of a psychiatric diagnosis in these associations. After finding no specific impact of patient or control status in this association, we decided to post-hoc study the transdiagnostic impact of depression severity in these associations.Resultsshowed 1) only a significant association between subjective executive control and a self-reported positive reappraisal style and corona-related reappraisal. However, after controlling for depression severity, this association was no longer significant. Additionally, objective executive control was only directly associated with right amygdala reactivity, while amygdala reactivity in neither of the hemispheres mediated the association between executive control and any of the coping styles. Furthermore, the type of diagnosis did not moderate the association between executive control and coping.ConclusionOur findings firstly underline the difference between self-reported and performance based executive control. While both deficits in subjective and performance based EC may play a role in the persistence of psychiatric symptomatology, this finding emphasizes how depressive symptoms or negative affect can impact reappraisal ability. As this ability is fundamental to staying resilient, treatments focused on reducing negative affect and thereby training reappraisal are pivotal in the maintenance of mental health in the entire population during environmental challenges.Competing Interest StatementThe authors have declared no competing interest.

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Section: Executive Control Measuresmentioning

confidence: 99%

“…1.0 × 1.0 × 1.0 mm, flip angle: 8°, GRAPPA acceleration factor: 2). [57] Pre-processing and first-and second-level analysis of the fMRI data were carried out in SPM12…”

Section: Amygdala Reactivity Measured By the Emotional Faces Processi...mentioning

confidence: 99%

Section: Executive Control Measuresmentioning

confidence: 99%

“…Anatomical images were acquired using a T1-weighted MP-RAGE sequence (TR = 2300 ms, TE = 3.03 ms, voxel size: 1.0 × 1.0 × 1.0 mm, flip angle: 8°, GRAPPA acceleration factor: 2). [57]…”

Section: Executive Control Measuresmentioning

confidence: 99%

Section: Executive Control Measuresmentioning

confidence: 99%

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How executive control and emotional reactivity influence coping strategies in psychiatric patients during the COVID-19 pandemic

Kist,

Schlüter,

Duyser

et al. 2024

Preprint

Self Cite

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A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder

et al. 2023

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The neurophysiological mechanisms in the human amygdala that underlie post-traumatic stress disorder (PTSD) remain poorly understood. In a first-of-its-kind pilot study, we recorded intracranial electroencephalographic data longitudinally (over one year) in two male individuals with amygdala electrodes implanted for the management of treatment-resistant PTSD (TR-PTSD) under clinical trial NCT04152993. To determine electrophysiological signatures related to emotionally aversive and clinically relevant states (trial primary endpoint), we characterized neural activity during unpleasant portions of three separate paradigms (negative emotional image viewing, listening to recordings of participant-specific trauma-related memories, and at-home-periods of symptom exacerbation). We found selective increases in amygdala theta (5–9 Hz) bandpower across all three negative experiences. Subsequent use of elevations in low-frequency amygdala bandpower as a trigger for closed-loop neuromodulation led to significant reductions in TR-PTSD symptoms (trial secondary endpoint) following one year of treatment as well as reductions in aversive-related amygdala theta activity. Altogether, our findings provide early evidence that elevated amygdala theta activity across a range of negative-related behavioral states may be a promising target for future closed-loop neuromodulation therapies in PTSD.

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Hippocampal sharp wave ripples mediate generalization and subsequent fear attenuation via closed-loop brain stimulation in rats

Pedraza,

Sierra,

Barcsai

et al. 2024

Preprint

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The balance between stimulus generalization and discrimination is essential in modulating behavioral responses across different contexts. Excessive fear generalization is linked to neuropsychiatric disorders such as generalized anxiety disorder (GAD) and PTSD. While hippocampal sharp wave-ripples (SWRs) and concurrent neocortical oscillations are central to the consolidation of contextual memories, their involvement in non-hippocampal dependent memories remains poorly understood. Here we show that closed-loop disruption of SWRs, after the consolidation of a cued fear conditioning, leads to atypical memory discrimination that would normally be generalized. Furthermore, SWR-triggered closed-loop stimulation of the basolateral amygdala (BLA) during memory reconsolidation inhibits fear generalization and enhances subsequent extinction. Comparable effects were observed when stimulating the infralimbic cortex either post-training or after a brief memory reactivation. A consistent increase in gamma incidence within the amygdala was identified in animals subjected to closed-loop BLA or infralimbic cortex neuromodulation. Our findings highlight the functional role of hippocampal SWRs in modulating the qualitative aspects of amygdala-dependent memories. Targeting the amygdala activity via prefrontal cortex with closed-loop SWR triggered stimulation presents a potential foundation of a non-invasive therapy for GAD and PTSD.

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Amygdala sensitivity for negative information as a neural marker for negative memory bias across psychiatric diagnoses

Cited by 4 publications

References 50 publications

How executive control and emotional reactivity influence coping strategies in psychiatric patients during the COVID-19 pandemic

How executive control and emotional reactivity influence coping strategies in psychiatric patients during the COVID-19 pandemic

A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder

Hippocampal sharp wave ripples mediate generalization and subsequent fear attenuation via closed-loop brain stimulation in rats

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