Amygdala responses to valence and its interaction by arousal revealed by MEG

Styliadis, Charis; Ioannides, Andreas A.; Bamidis, Panagiotis D.; Papadelis, Christos

doi:10.1016/j.ijpsycho.2013.05.006

Cited by 36 publications

(45 citation statements)

References 131 publications

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“…Styalidis et al, 2014;Yoder et al, 2015). This limitation is most pronounced for the nuclei of the dorsal AG.…”

Section: Discussionmentioning

confidence: 93%

“…Furthermore, there are substantial variations in methodology used to localize intra-AG activations. Generally, two main references have been used: Mai (2008) anatomical atlas (Bach et al, 2011;Boll et al, 2011Boll et al, , 2013Gamer et al, 2010;Prévost et al, 2011Prévost et al, , 2012Prévost et al, , 2013 or Amunts et al (2005) probabilistic atlas of the human AG subnuclei (Ball et al 2007(Ball et al , 2009Frühholz and Grandjean, 2013;Grant et al, 2015;Roy et al, 2009;Styalidis et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Amygdala subnuclei response and connectivity during emotional processing

Hrybouski

Aghamohammadi‐Sereshki

Madan

et al. 2016

NeuroImage

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The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emotions. Here we combined a novel anatomical tracing protocol with eventrelated high-resolution fMRI acquisition to study the responsiveness of the amygdala subnuclei to negative emotional stimuli and to examine intra-amygdala functional connectivity. The greatest sensitivity to negative emotional stimuli was observed in the centromedial amygdala, where the hemodynamic response amplitude elicited by negative emotional stimuli was greater and peaked later than for neutral stimuli. Connectivity patterns converge with extant findings in animals, such that the strongest connectivity was between the lateral nucleus and the nuclei of the basal amygdala. Current findings provide evidence of functional specialization within the human amygdala.

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“…Styalidis et al, 2014;Yoder et al, 2015). This limitation is most pronounced for the nuclei of the dorsal AG.…”

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Amygdala subnuclei response and connectivity during emotional processing

Hrybouski

Aghamohammadi‐Sereshki

Madan

et al. 2016

NeuroImage

View full text Add to dashboard Cite

show abstract

“…Future research should therefore employ affective stimuli that systematically control for the effects of arousal and valence, so as to disentangle these effects and avoid findings being potentially confounded due to an interaction between arousal and valence. In fact, a recent neuroimaging study done in healthy adults assessed amygdala responding to IAPS pictures (Styliadis et al, 2013), which permitted the researchers to manipulate arousal levels (high and low) and valence levels (pleasant and unpleasant). Findings were limited however, since the IAPS collection does not have enough picture stimuli matched on ratings of arousal and valence for males and females, meaning that male and female participants had to view different stimuli.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological correlates of dysregulated emotional arousal in severe traumatic brain injury

Fisher

Rushby

McDonald

et al. 2015

Clinical Neurophysiology

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“…Given apparent lateralization effects in amygdalar functionality and subregional connectivity [Aghajani et al 2016, 2016; Baas et al, 2004; Brown et al, 2014; Gabard‐Durnam et al, 2014; Qin et al, 2014; Sergerie et al, 2008; Styliadis et al, 2014], and in line with recent work [Aghajani et al, 2016; Qin et al, 2012, 2014], BLA and CMA region of interest (ROI) masks were created in each hemisphere (see Supporting Information), and used to extract individual participant's mean time series within BLA and CMA complexes. Seed‐based whole‐brain iFC analysis implemented within FSL FEAT [Jenkinson et al, 2012], was then employed to reveal BLA and CMA connectivity patterns [Fox and Raichle, 2007].…”

Section: Methodsmentioning

confidence: 99%

Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders

Aghajani

Colins

Klapwijk

et al. 2016

Human Brain Mapping

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Psychopathy is a serious psychiatric phenomenon characterized by a pathological constellation of affective (e.g., callous, unemotional), interpersonal (e.g., manipulative, egocentric), and behavioral (e.g., impulsive, irresponsible) personality traits. Though amygdala subregional defects are suggested in psychopathy, the functionality and connectivity of different amygdala subnuclei is typically disregarded in neurocircuit‐level analyses of psychopathic personality. Hence, little is known of how amygdala subregional networks may contribute to psychopathy and its underlying trait assemblies in severely antisocial people. We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral (BLA) and centromedial (CMA) amygdala networks in relation to affective, interpersonal, and behavioral traits of psychopathy, in conduct‐disordered juveniles with a history of serious delinquency (N = 50, mean age = 16.83 ± 1.32). As predicted, amygdalar connectivity profiles exhibited dissociable relations with different traits of psychopathy. Interpersonal psychopathic traits not only related to increased connectivity of BLA and CMA with a corticostriatal network formation accommodating reward processing, but also predicted stronger CMA connectivity with a network of cortical midline structures supporting sociocognitive processes. In contrast, affective psychopathic traits related to diminished CMA connectivity with a frontolimbic network serving salience processing and affective responding. Finally, behavioral psychopathic traits related to heightened BLA connectivity with a frontoparietal cluster implicated in regulatory executive functioning. We suggest that these trait‐specific shifts in amygdalar connectivity could be particularly relevant to the psychopathic phenotype, as they may fuel a self‐centered, emotionally cold, and behaviorally disinhibited profile. Hum Brain Mapp 37:4017–4033, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Amygdala responses to valence and its interaction by arousal revealed by MEG

Cited by 36 publications

References 131 publications

Amygdala subnuclei response and connectivity during emotional processing

Amygdala subnuclei response and connectivity during emotional processing

Neurophysiological correlates of dysregulated emotional arousal in severe traumatic brain injury

Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders

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