Amygdala-prefrontal connectivity during emotion regulation: A meta-analysis of psychophysiological interactions

Berboth, Stella; Morawetz, Carmen

doi:10.1016/j.neuropsychologia.2021.107767

Cited by 117 publications

(101 citation statements)

References 65 publications

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“…. Meta-analyses of emotion regulation studies support the latter model in which conscious reappraisal does not rely on vmPFC to influence amygdala activity 21,38 . Instead, the vmPFC may influence the amygdala more during implicit emotion regulation processes 20 .…”

mentioning

confidence: 88%

Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial

Nashiro

Min

Yoo

et al. 2021

Preprint

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Heart rate variability is a robust biomarker of emotional well-being, consistent with the shared brain networks regulating emotion regulation and heart rate. While high heart rate oscillatory activity clearly indicates healthy regulatory brain systems, can increasing this oscillatory activity also enhance brain function? To test this possibility, we randomly assigned 106 young adult participants to one of two 5-week interventions involving daily biofeedback that either increased heart rate oscillations (Osc+ condition) or had little effect on heart rate oscillations (Osc- condition) and examined effects on brain activity during rest and during regulating emotion. In this healthy cohort, the two conditions did not differentially affect anxiety, depression or mood. However, the Osc+ intervention increased low-frequency heart rate variability and increased brain oscillatory dynamics and functional connectivity in emotion-related resting-state networks. It also increased down-regulation of activity in somatosensory brain regions during an emotion regulation task. The Osc- intervention did not have these effects. These findings indicate that heart rate oscillatory activity not only reflects the current state of regulatory brain systems but also changes how the brain operates beyond the moments of high oscillatory activity.

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mentioning

confidence: 88%

Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial

Nashiro

Min

Yoo

et al. 2021

Preprint

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“…Notably, they did not observe increased activation of the vmPFC. There are many possible reasons for these differences in findings (see [121,136,137] for discussion), however, one possibility is that it has to do with the type of cognitive reappraisal procedure used. The study by Delgado etv al.…”

Section: Emotion Regulationmentioning

confidence: 99%

Prefrontal cortex, amygdala, and threat processing: implications for PTSD

Kredlow

Fenster

Laurent

et al. 2021

Neuropsychopharmacol.

130

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Posttraumatic stress disorder can be viewed as a disorder of fear dysregulation. An abundance of research suggests that the prefrontal cortex is central to fear processing—that is, how fears are acquired and strategies to regulate or diminish fear responses. The current review covers foundational research on threat or fear acquisition and extinction in nonhuman animals, healthy humans, and patients with posttraumatic stress disorder, through the lens of the involvement of the prefrontal cortex in these processes. Research harnessing advances in technology to further probe the role of the prefrontal cortex in these processes, such as the use of optogenetics in rodents and brain stimulation in humans, will be highlighted, as well other fear regulation approaches that are relevant to the treatment of posttraumatic stress disorder and involve the prefrontal cortex, namely cognitive regulation and avoidance/active coping. Despite the large body of translational research, many questions remain unanswered and posttraumatic stress disorder remains difficult to treat. We conclude by outlining future research directions related to the role of the prefrontal cortex in fear processing and implications for the treatment of posttraumatic stress disorder.

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“…Neuroimaging studies have identified a consistent set of brain regions that support the cognitive reappraisal of negative emotions elicited by provocative stimuli, typically visual images. This network comprises the dorsolateral prefrontal cortex (dlPFC), presupplementary motor area (preSMA) and the dorsal anterior cingulate cortex (dACC) [6][7][8], whose increased activity consistently accompanies the successful down-regulation of emotion, together with the modulation of activity in other brain regions, including the amygdala [9,10]. Whether this network also supports the cognitive restructuring of negative self-beliefs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

A thalamo-centric neural signature for restructuring negative self-beliefs

Steward

Kung

Davey

et al. 2021

Preprint

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Negative self-beliefs are a core feature of psychopathology. Despite this, we have a limited understanding of the brain mechanisms by which negative self-beliefs are cognitively restructured. Using a novel paradigm, we had participants use Socratic questioning techniques to restructure self-beliefs during ultra-high resolution 7-Tesla functional magnetic resonance imaging (UHF fMRI) scanning. Cognitive restructuring elicited prominent activation in a fronto-striato-thalamic circuit, including the mediodorsal thalamus (MD), a group of deep subcortical nuclei believed to synchronize and integrate prefrontal cortex activity, but which has seldom been directly examined with fMRI due to its small size. Increased activity was also identified in the medial prefrontal cortex (MPFC), a region consistently activated by internally focused mental processing, as well as in lateral prefrontal regions associated with regulating emotional reactivity. Using Dynamic Causal Modelling (DCM), evidence was found to support the MD as having a strong excitatory effect on the activity of regions within the broader network mediating cognitive restructuring. Moreover, the degree to which participants modulated MPFC-to-MD effective connectivity during cognitive restructuring predicted their individual tendency to engage in repetitive negative thinking. Our findings represent a major shift from a cortico-centric framework of cognition and provide important mechanistic insights into how the MD facilitates key processes in cognitive interventions for common psychiatric disorders. In addition to relaying integrative information across basal ganglia and the cortex, we propose a multifaceted role for the MD whose broad excitatory pathways act to increase synchrony between cortical regions to sustain complex mental representations, including the self.

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Amygdala-prefrontal connectivity during emotion regulation: A meta-analysis of psychophysiological interactions

Cited by 117 publications

References 65 publications

Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial

Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial

Prefrontal cortex, amygdala, and threat processing: implications for PTSD

A thalamo-centric neural signature for restructuring negative self-beliefs

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