Amygdala modulates memory for changes in reward magnitude: Reversible post-training inactivation with lidocaine attenuates the response to a reduction in reward

Salinas, Juan A.; Packard, Mark G.; McGaugh, James L.

doi:10.1016/0166-4328(93)90162-j

Cited by 68 publications

(44 citation statements)

References 30 publications

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“…Several other findings support the notion that the LBA makes a rather fundamental contribution to learning about the incentive value of anticipated outcomes (Hatfield et al, 1996;Blundell et al, 2003;Pickens et al, 2003;Holland and Gallagher, 2004). Although the specific nature of its involvement remains poorly understood, there is some evidence that the LBA plays a role in the consolidation of changes in incentive value produced by incentive contrast (Salinas et al, 1993;cf. Flaherty, 1996).…”

Section: Introductionmentioning

confidence: 62%

Consolidation and Reconsolidation of Incentive Learning in the Amygdala

Wang

Ostlund²,

Nader³

et al. 2005

J. Neurosci.

107

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Incentive learning is the process via which animals update changes in the value of rewards. Current evidence suggests that, for food rewards in rats, this learning process involves the amygdala. However, it remains unclear whether this learning undergoes protein synthesis-dependent consolidation and "reconsolidation" processes in the lateral and basal nuclei of amygdala. Accordingly, we examined this hypothesis by local infusion of protein-synthesis inhibitor after devaluation of a food reward induced by a shift from a fooddeprived to a food-sated state in an instrumental conditioning paradigm. Our results show that intra-amygdala infusions of anisomycin, whether given after the initial devaluation or after a second devaluation session, abolished the changes in the value of the food reward produced by incentive learning. This study provides direct evidence that instrumental incentive learning depends on protein synthesis within the amygdala for both consolidation and reconsolidation and extends the demonstrations of protein synthesis-dependent reconsolidation to reward-related memories.

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Section: Introductionmentioning

confidence: 62%

Consolidation and Reconsolidation of Incentive Learning in the Amygdala

Wang

Ostlund²,

Nader³

et al. 2005

J. Neurosci.

107

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“…If we seek to understand how drug-associated memories control and lead to compulsive drug-seeking behavior, an important test would be to explore whether the CS now associated with the increased incentive value of heroin also undergoes protein synthesis-dependent reconsolidation in the BLA. There is good evidence to suggest that the BLA is involved in incentive learning (Everitt et al, 1999;Balleine et al, 2003) and consolidation of memory for changes in the incentive value of rewards (Salinas et al, 1993). Moreover, reconsolidation of incentive memory for different food outcomes is blocked by intra-BLA infusions of anisomycin (Wang et al, 2005), suggesting that incentive learning for natural rewards undergoes protein synthesis-dependent reconsolidation in the BLA.…”

Section: Discussionmentioning

confidence: 99%

Disrupting Reconsolidation of Conditioned Withdrawal Memories in the Basolateral Amygdala Reduces Suppression of Heroin Seeking in Rats

Hellemans¹,

Everitt²

2006

J. Neurosci.

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Recent data from our laboratory have demonstrated that appetitive drug memories undergo protein synthesis-dependent reconsolidation in the basolateral amygdala (BLA), an area important in the formation of emotional memories. We here investigated the importance of the BLA in the reconsolidation of opiate conditioned withdrawal memories. Rats with bilateral cannulas implanted in the BLA were trained to respond for heroin (0.12 mg/kg, i.v.) under a seeking-taking schedule, which required responding on a seeking lever to gain the opportunity to self-administer heroin by a single response on a taking lever. After induction of opiate dependence with subcutaneously implanted, heroin-filled osmotic minipumps (3 mg ⅐ kg Ϫ1 ⅐ d Ϫ1 heroin), rats received five consecutive pairings of a conditioned stimulus (CS) (tone, light, and odor compound) paired with naloxone (0.10 mg/kg, s.c.)-precipitated withdrawal. We replicated our previous findings that heroin seeking is suppressed in the presence of the withdrawal-associated CS. However, infusion of Zif268 antisense oligodeoxynucleotide into the BLA before reactivation of the CS-withdrawal association abolished this conditioned suppression in a reactivation-dependent manner. We also report that reconsolidation of CS-withdrawal memories upregulates Zif268 protein in the basolateral but not central nucleus of the amygdala and that Zif268 knockdown occurs selectively in the BLA. These results demonstrate that drug withdrawal memories undergo protein synthesis-dependent reconsolidation in the BLA and suggest a common mechanism for the reconsolidation of both appetitive and aversive drug memories.

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“…The basolateral amygdala plays an important role in detecting changes in the magnitude of expected rewards or incentive value of instrumental outcome (Corbit & Balleine, 2005;Salinas, Packard, & McGaugh, 1993). In addition, lesions of this region of the amygdala increase impulsive choice in a delay-discounting paradigm, in a manner similar to lesions of the NAc (Winstanley et al, 2004).…”

Section: Delay-based Decision Makingmentioning

confidence: 99%