Amygdala hypersensitivity in response to emotional faces in Tourette's patients

Neuner, Irene; Kellermann, Thilo; Stöcker, Tony; Kircher, Tilo; Habel, Ute; Shah, N. Jon; Schneider, Frank

doi:10.3109/15622975.2010.480984

Cited by 47 publications

(38 citation statements)

References 75 publications

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“…Hypertrophy of the limbic and pre-frontal cortices, and a smaller corpus callosum are associated with less pronounced tics in children with TS (Plessen et al, 2009). Regarding the function, amygdala hypersensitivity and alterations of its structure and functional connectivity have been described (Neuner et al, 2010a; Werner et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Imaging the where and when of tic generation and resting state networks in adult Tourette patients

Neuner

Werner

Arrubla

et al. 2014

Front. Hum. Neurosci.

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Introduction: Tourette syndrome (TS) is a neuropsychiatric disorder with the core phenomenon of tics, whose origin and temporal pattern are unclear. We investigated the When and Where of tic generation and resting state networks (RSNs) via functional magnetic resonance imaging (fMRI).Methods: Tic-related activity and the underlying RSNs in adult TS were studied within one fMRI session. Participants were instructed to lie in the scanner and to let tics occur freely. Tic onset times, as determined by video-observance were used as regressors and added to preceding time-bins of 1 s duration each to detect prior activation. RSN were identified by independent component analysis (ICA) and correlated to disease severity by the means of dual regression.Results: Two seconds before a tic, the supplementary motor area (SMA), ventral primary motor cortex, primary sensorimotor cortex and parietal operculum exhibited activation; 1 s before a tic, the anterior cingulate, putamen, insula, amygdala, cerebellum and the extrastriatal-visual cortex exhibited activation; with tic-onset, the thalamus, central operculum, primary motor and somatosensory cortices exhibited activation. Analysis of resting state data resulted in 21 components including the so-called default-mode network. Network strength in those regions in SMA of two premotor ICA maps that were also active prior to tic occurrence, correlated significantly with disease severity according to the Yale Global Tic Severity Scale (YGTTS) scores.Discussion: We demonstrate that the temporal pattern of tic generation follows the cortico-striato-thalamo-cortical circuit, and that cortical structures precede subcortical activation. The analysis of spontaneous fluctuations highlights the role of cortical premotor structures. Our study corroborates the notion of TS as a network disorder in which abnormal RSN activity might contribute to the generation of tics in SMA.

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Section: Introductionmentioning

confidence: 99%

Imaging the where and when of tic generation and resting state networks in adult Tourette patients

Neuner

Werner

Arrubla

et al. 2014

Front. Hum. Neurosci.

Self Cite

156

129

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“…Neuner et al 36 investigated the perception of six emotional facial expressions in adults with TS. Compared with healthy controls, significantly higher amygdala activation was found in patients with TS.…”

Section: Functional Correlates Of Perception and Listeningmentioning

confidence: 99%

Functional neuroimaging in Tourette syndrome: recent perspectives

Debes¹,

Préel²,

Skov³

2017

NAN

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“…Thus, findings regarding increased sensitivity to aversive and ambiguous cues (Neuner et al, 2010) may have been due to ADHD comorbidity. BIS-anxiety and FFFS-fear were also associated with motor TS and OCBs in the zero-order correlations, but did not uniquely contribute to either.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have found (i) greater amygdala activation for fearful, angry and neutral facial expressions in TS patients (though comorbidity was not controlled; Neuner et al, 2010); (ii) impaired punishment learning in unmedicated TS patients, whereas reward sensitivity and reward learning were only reduced in medicated and OCD-comorbid TS patients (Palminteri et al, 2009; and (iii) no differences in reward learning between pure TS patients and healthy controls (Crawford, Channon & Robertson, 2005). These findings suggest increased sensitivity to aversive and ambiguous cues (overactive FFFS and BIS) but deficits in negative reinforcement learning (dysfunctional FFFS or BIS) in TS, whereas reward processing deficits (underactive BAS) appear to be linked to medication status and presence of OCD symptoms.…”

Section: Reinforcement Sensitivity In Adhd and Tsmentioning

confidence: 99%

Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population

Heym

Kantini

Checkley

et al. 2015

Personality and Individual Differences

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, they show comorbidity and inhibitory control deficits have been proposed to underlie both. The role of reinforcement sensitivity in ADHD has been studied previously, but no study has addressed this in relation to TS-like behaviors in the general population. The present study examined these associations within the remit of the revised Reinforcement Sensitivity Theory (rRST). One hundred and thirty-eight participants completed psychometric measures of the rRST, and self-report checklists for ADHD-and TS-like behaviors. The results show that whilst ADHD-inattention was only linked to increased anxiety (BIS), ADHD-hyperactivity/impulsivity was linked to increased impulsivity (BAS-fun seeking), anxiety (BIS) and punishment sensitivity (FFFS), and to reduced reward sensitivity (BAS-reward responsiveness), independently of 'comorbid' TS-like behaviors. TS-related phonic tics were associated with increased BIS and FFFS, and TS-related obsessive-compulsive behaviors (OCBs) with increased goal-orientation (BAS-drive) and reduced impulsivity (BAS-fun seeking). However, these associations were driven by ADHD-like behaviors or OCB cooccurrence, respectively, suggesting little role of the rRST in pure TS-like behaviors. The results are discussed in light of mixed findings in the literature and the importance of distinguishing between multiple processing models of the rRST in distinct disorder phenotypes.

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Amygdala hypersensitivity in response to emotional faces in Tourette's patients

Cited by 47 publications

References 75 publications

Imaging the where and when of tic generation and resting state networks in adult Tourette patients

Imaging the where and when of tic generation and resting state networks in adult Tourette patients

Functional neuroimaging in Tourette syndrome: recent perspectives

Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population

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