Amygdala functional connectivity is associated with social impairments in preterm born young adults

Johns, Christina B.; Lacadie, Cheryl; Vohr, Betty R.; Ment, Laura R.; Scheinost, Dustin

doi:10.1016/j.nicl.2018.101626

Cited by 46 publications

(55 citation statements)

References 57 publications

(82 reference statements)

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“…This finding may suggest that right amygdala rs‐FC may be a sensitive measure of environment‐related alterations in the developing brain. Indeed, cumulative evidence of rs‐fMRI studies of neural correlates of early‐life environment in singleton and twin populations indicated alterations in (right) amygdala‐based rs‐FC with other regions of the limbic neurocircuitry including insula, hippocampus, as well as orbitofrontal and anterior cingulate cortices (e.g., Grewen, Salzwedel, & Gao, 2015; Johns et al, 2019; Qiu et al, 2015; Salzwedel et al, 2019; Scheinost et al, 2016). Moreover, and unlike the hippocampus, since the right amygdala rs‐FC was linked to BW in both analyses, and in particular the within‐pair discordance analysis, we might argue that connectivity showed a greater influence of individual unique environment than genetic factors.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, even when BW is within the normal range, structural associations with BW have been found throughout the brain, particularly in midline structures such as the anterior cingulate cortex, paracentral lobule, and precuneus, along with the orbitofrontal, inferior parietal, and temporal cortices (Haukvik et al, 2014; Shang et al, 2019; Walhovd et al, 2012). Additionally, a recent study found that adolescents born very preterm showed altered rs‐FC between the amygdala and various regions (e.g., hippocampus, prefrontal cortex), relative to adolescents born at term with normal weight (Johns, Lacadie, Ment, & Scheinost, 2019). Overall, these studies support the relevance of in utero environment for long‐term typical and atypical structural and functional brain development.…”

Section: Introductionmentioning

confidence: 99%

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Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins

Hayward

Pomares

Casey

et al. 2020

Human Brain Mapping

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Previous research has shown that the prenatal environment, commonly indexed by birth weight (BW), is a predictor of morphological brain development. We previously showed in monozygotic (MZ) twins associations between BW and brain morphology that were independent of genetics. In the present study, we employed a longitudinal MZ twin design to investigate whether variations in prenatal environment (as indexed by discordance in BW) are associated with resting-state functional connectivity (rs-FC) and with structural connectivity. We focused on the limbic and default mode networks (DMNs), which are key regions for emotion regulation and internally generated thoughts, respectively. One hundred and six healthy adolescent MZ twins (53 pairs; 42% male pairs) followed longitudinally from birth underwent a magnetic resonance imaging session at age 15. Graph theoretical analysis was applied to rs-FC measures. TrackVis was used to determine track count as an indicator of structural connectivity strength. Lower BW twins had less efficient limbic network connectivity as compared to their higher BW co-twin, driven by differences in the efficiency of the right hippocampus and right amygdala. Lower BW male twins had fewer tracks

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins

Hayward

Pomares

Casey

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Preterm birth affects approximately 11% of global live births and is associated with adverse neuropsychiatric and developmental outcomes (31)(32)(33)(34)(35)(36). A number of studies have focused on investigating the relationship between brain development and these adverse outcomes (37)(38)(39), with aberrant white matter microstructural development (38,(40)(41)(42) being commonly reported.…”

mentioning

confidence: 99%

Maternal Prenatal Stress Is Associated With Altered Uncinate Fasciculus Microstructure in Premature Neonates

Lautarescu

Pecheva

Nosarti

et al. 2020

Biological Psychiatry

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BACKGROUND: Maternal prenatal stress exposure (PNSE) increases risk for adverse psychiatric and behavioral outcomes in offspring. The biological basis for this elevated risk is poorly understood but may involve alterations to the neurodevelopmental trajectory of white matter tracts within the limbic system, particularly the uncinate fasciculus. Additionally, preterm birth is associated with both impaired white matter development and adverse developmental outcomes. In this study we hypothesized that higher maternal PNSE was associated with altered uncinate fasciculus microstructure in offspring. METHODS: In this study, 251 preterm infants (132 male, 119 female) (median gestational age = 30.29 weeks [range, 23.57-32.86 weeks]) underwent brain magnetic resonance imaging including diffusion-weighted imaging around term-equivalent age (median = 42.43 weeks [range, 37.86-45.71 weeks]). Measures of white matter microstructure were calculated for the uncinate fasciculus and the inferior longitudinal fasciculus, a control tract that we hypothesized was not associated with maternal PNSE. Multiple regressions were used to investigate the relationship among maternal trait anxiety scores, stressful life events, and white matter microstructure indices in the neonatal brain. RESULTS: Adjusting for gestational age at birth, postmenstrual age at scan, maternal age, socioeconomic status, sex, and number of days on parenteral nutrition, higher stressful life events scores were associated with higher axial diffusivity (b = .177, q = .007), radial diffusivity (b = .133, q = .026), and mean diffusivity (b = .149, q = .012) in the left uncinate fasciculus, and higher axial diffusivity (b = .142, q = .026) in the right uncinate fasciculus. CONCLUSIONS: These findings suggest that PNSE is associated with altered development of specific frontolimbic pathways in preterm neonates as early as term-equivalent age.

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“…Guo's study also supported that adolescents with autism showed decreased FC between the amygdala and subcortical regions (Guo et al 2016). Meanwhile, increased social impairment was found in preterm-born adolescents compared to their term-born peers, and amygdala connectivity was altered in those prematurely-born, markers of social functioning were correlated with altered amygdala-PCC connectivity (Johns et al 2019). In our study, individuals with autistic traits showed FC between the right MTG and the left PHG rather than the amygdala, which is consistent with the results of previous studiest.…”

Section: Discussionmentioning

confidence: 76%

“…Baron-Cohen,. et al 2000;Guo et al 2016;Johns et al 2019;Van Reekum et al 2007). In Ashwin's study, higher activation was observed in the left amygdala and orbito-frontal cortex in control subjects, while the ASD group showed higher activation in the anterior cingulate and superior temporal gyrus (Ashwin et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The role of the MTG in negative emotional processing in young adults with autistic traits: a fMRI task study

Wang

Ward

et al. 2019

Preprint

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Individuals with autistic traits are those within the normal population who demonstrate social, communication, and cognitive impairments but who do not meet the clinical threshold for autism spectrum disorder (ASD). ASD is a pervasive neurodevelopmental disorder associated with deficits in high-level cognitive functions such as negative emotion processing and social cognitive processing, and people with autistic traits also have these impairments. Few previous studies have explored negative emotion processing in people with autistic traits using task-based functional magnetic resonance imaging (fMRI). In this study, we focused on the behaviors of a large sample (N=104) of Chinese individuals with different levels of autistic traits, who we tested using a popular questionnaire called the autism spectrum quotient (AQ). We then applied task fMRI to determine negative emotion processing and social cognition associated with differences in brain activation and functional connectivity. The results mainly showed significantly positive activation in the right middle temporal gyrus (MTG), and the right hippocampus gyrus (HG) in multiple regression analysis. More importantly, mediation analysis showed that the right MTG suppresses the relationship between AQ (total) score and negative emotional processing, showing that a higher autistic trait score in individuals leads to a smaller difference between the rating of negative images and the neutral images. Furthermore, generalized psychophysiological interaction analyses (gPPI) analysis also suggested that the right MTG shows significant functional connectivity (FC) with the left parahippocampal gyrus (PHG), suggesting that individuals with autistic traits have high level of spontaneous negative emotion. According to these findings, we assumed that the MTG might have a specific effect on processing negative emotion in individuals with autistic traits related to weaker to social emotion ability. The emotion perception mechanisms in the MTG region may be affected by atypical negative emotion processing in other brain regions such as HG and PHG, during a negative emotion processing task with socially emotion-relevant information in individuals with autistic traits.

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Amygdala functional connectivity is associated with social impairments in preterm born young adults

Cited by 46 publications

References 57 publications

Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins

Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins

Maternal Prenatal Stress Is Associated With Altered Uncinate Fasciculus Microstructure in Premature Neonates

The role of the MTG in negative emotional processing in young adults with autistic traits: a fMRI task study

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