Amygdala-based intrinsic functional connectivity and anxiety disorders in adolescents and young adults

Toazza, Rudineia; Franco, Alexandre R.; Buchweitz, Augusto; Molle, Roberta Dalle; Rodrigues, Danitsa Marcos; Reis, Roberta Sena; Mucellini, Amanda Brondani; Esper, Nathália Bianchini; Aguzzoli, Cristiano; Silveira, Patrícia Pelufo; Salum, Giovanni Abrahão; Manfro, Gisele Gus

doi:10.1016/j.pscychresns.2016.09.010

Cited by 23 publications

(22 citation statements)

References 32 publications

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“…Findings of altered amygdala‐prefrontal RSFC in children with anxiety disorders are inconsistent, with some reporting increased (Roy et al., ; Toazza et al., ) and others reporting decreased (Hamm et al., ; Sylvester et al., ) connectivity from amygdala to prefrontal cortices compared to healthy children. These discrepancies likely arise from differences across the ages and specific anxiety disorders included in the samples and methodological differences, including the regions or subregions used as seeds in the RSFC analyses.…”

Section: Introductionmentioning

confidence: 99%

“…Both reading impairment and anxiety symptoms may arise from a common neurobiological mechanism such as functional connectivity from amygdala to prefrontal cortices since prefrontal cortices modulate amygdala responses to exert control over emotions, thereby implicating these circuits in anxiety and emotion regulation (Diamond, 2013;Ochsner & Gross, 2005;Taylor & Whalen, 2015). FMRI findings suggest that age-related decreases in connectivity from amygdala to medial and dorsolateral prefrontal cortices from childhood to adolescence coincides with the development of emotion regulation (Gee et al, 2013;Prater, Hosanagar, Klumpp, Angstadt, & Phan, 2013), and that connectivity from amygdala to ventral and medial prefrontal regions is altered in children with anxiety disorders (Hamm et al, 2014;Prater et al, 2013;Roy et al, 2013;Sylvester et al, 2013;Toazza et al, 2016). Amygdala to prefrontal connectivity is also altered in association with self-reported math anxiety (Supekar, Iuculano, Chen, & Menon, 2015;Wu, Willcutt, Escovar, & Menon, 2014;Young, Wu, & Menon, 2012), but the neural correlates of anxiety related to reading have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to the sparse findings from RD samples, RSFC has been used extensively to study the neural underpinnings of anxiety, with focus on the amygdala-prefrontal circuits involved in emotion regulation (Brown et al, 2014;Etkin, 2010;Gee et al, 2013;Hahn et al, 2011;Hamm et al, 2014;S.H. Kim & Hamann, 2007;Liao et al, 2010;Prater et al, 2013;Qin et al, 2014;Roy et al, 2009Roy et al, , 2013Sripada et al, 2012;Sylvester et al, 2013;Toazza et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Amygdala sub‐regional functional connectivity predicts anxiety in children with reading disorder

Davis

Margolis

Thomas

et al. 2017

Developmental Science

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Pediatric reading disorder (RD) is associated with an increased risk of anxiety symptoms, yet understudied are the neurobiological factors that might underlie anxiety in children with RD. Given the role of the amygdala in anxiety, we assessed resting state functional connectivity of amygdalar subregions in children with RD to identify functional correlates of anxiety and reading impairment. We collected resting state functional MRI data from 22 children with RD and 21 typically developing (TD) children, ages 7 to 13 years. We assessed group differences in resting state functional connectivity (RSFC) from amygdalar subregions. Associations of amygdalar RSFC and volume with reading impairment, reading fluency scores, and anxiety symptoms were explored. Relative to TD children, those with RD showed increased RSFC from amygdalar nuclei to medial prefrontal cortex. Across all subjects, RSFC from right centromedial amygdala to left medial prefrontal cortex positively predicted both reading impairment and self-reported anxiety, and anxiety mediated the relationship between RSFC and reading impairment. These findings are consistent with amygdalar functional abnormalities in pediatric anxiety disorders, suggesting a common neurobiological mechanism underlying anxiety and reading impairment in children. Thus, aberrant patterns of RSFC from amygdalar subregions may serve as potential targets for the treatment of anxiety symptoms that typically co-occur with RD. Our dimensional approach to studying anxiety in RD revealed how amygdalar connectivity underlies anxiety and reading impairment across a continuum from normal to abnormal.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amygdala sub‐regional functional connectivity predicts anxiety in children with reading disorder

Davis

Margolis

Thomas

et al. 2017

Developmental Science

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“…Differences in amygdala‐fusiform connectivity have been found in association with adolescent anxiety disorders (Toazza et al ., ), early‐life stress and institutionalization (Herringa et al ., ; Malter Cohen, Jing, et al ., ; Silvers et al ., ), and PTSD (Cisler et al ., ). The choice of brain region pairs was not exploratory, but we carried out a correction for multiple comparisons for the correlations among the Z‐ scores for activation time series and the JVQ scores.…”

Section: Resultsmentioning

confidence: 99%

“…Brain imaging has shown atypical amygdala function and connectivity associated with adolescent anxiety disorders (Toazza, Franco, Buchweitz, Molle, Rodrigues, Reis, & Manfro, 2016), early-life stress and institutionalization (Herringa, Burghy, Stodola, Fox, Davidson, & Essex, 2016;Malter Cohen, Jing, et al, 2013;Silvers et al, 2016), and PTSD (Cisler, Bush, James, Smitherman, & Kilts, 2015). Atypical fusiform gyrus connectivity, in turn, has been shown in association with social anxiety (Frick, Howner, Fischer, Kristiansson, & Furmark, 2013).…”

Section: Research Highlightsmentioning

confidence: 99%

Violence and Latin‐American preadolescents: A study of social brain function and cortisol levels

Buchweitz

Azeredo

Sanvicente‐Vieira

et al. 2019

Developmental Science

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The present study investigated exposure to violence and its association with brain function and hair cortisol concentrations in Latin‐American preadolescents. Self‐reported victimization scores (JVQ‐R2), brain imaging (fMRI) indices for a social cognition task (the ‘eyes test’), and hair cortisol concentrations were investigated, for the first time, in this population. The eyes test is based on two conditions: attributing mental state or sex to pictures of pairs of eyes (Baron‐Cohen, Wheelwright, Hill, Raste, & Plumb, 2001). The results showed an association among higher victimization scores and (a) less activation of posterior temporoparietal right‐hemisphere areas, in the mental state condition only (including right temporal sulcus and fusiform gyrus); (b) higher functional connectivity indices for the Amygdala and Right Fusiform Gyrus (RFFG) pair of brain regions, also in the mental state condition only; (c) higher hair cortisol concentrations. The results suggest more exposure to violence is associated with significant differences in brain function and connectivity. A putative mechanism of less activation in posterior right‐hemisphere regions and of synchronized Amygdala: RFFG time series was identified in the mental state condition only. The results also suggest measurable effects of exposure to violence in hair cortisol concentrations, which contribute to the reliability of self‐reported scores by young adolescents. The findings are discussed in light of the effects of exposure to violence on brain function and on social‐cognitive development in the adolescent brain. A video abstract of this article can be viewed at https://www.youtube.com/watch?v=qHcXq7Y9PBk

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ENIGMA‐anxietyworking group: Rationale for and organization oflarge‐scaleneuroimaging studies of anxiety disorders

Bas-Hoogendam

Groenewold

Aghajani

et al. 2020

Human Brain Mapping

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Amygdala-based intrinsic functional connectivity and anxiety disorders in adolescents and young adults

Cited by 23 publications

References 32 publications

Amygdala sub‐regional functional connectivity predicts anxiety in children with reading disorder

Amygdala sub‐regional functional connectivity predicts anxiety in children with reading disorder

Violence and Latin‐American preadolescents: A study of social brain function and cortisol levels

ENIGMA‐anxietyworking group: Rationale for and organization oflarge‐scaleneuroimaging studies of anxiety disorders

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