Amygdala Atrophy in Alzheimer's Disease

Cuénod, Charles‐André; Denys, Alban; Michot, Jean–Luc; Jehenson, P.; Forette, Françoise; Kaplan, David B.; Syrota, A.; Boller, François

doi:10.1001/archneur.1993.00540090046009

Cited by 163 publications

(28 citation statements)

References 24 publications

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“…In agreement with our results, different au thors reported pronounced temporal lobe and hippocam pal atrophy in DAT, other structures being less affected Dement Gcriatr Cogn Disord 1997;8:329-336by atrophy [4,19,20,28,41,[46][47][48][49][50][51]. According to several authors [21,23,[52][53][54] atrophy of the hippocampal for mation and of the temporal lobes in patients with DAT (in comparison with normal controls) was more pro nounced than atrophy of other brain structures.…”

Section: Atrophy O F Amygdala-hippocampal Complexes and Temporal Lobesupporting

confidence: 90%

Amygdala-Hippocampal Atrophy and Memory Performance in Dementia of Alzheimer Type

Heun

Mazanek

Atzor

et al. 1997

Dement Geriatr Cogn Disord

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The aim of the present study was to examine the involvement of brain structures, especially the amygdala-hippocampal complex, in dementia of Alzheimer type (DAT), and to assess the relation of amygdala-hippocampal atrophy with memory dysfunction. 14 patients with DAT and 10 healthy age-matched controls were examined with different neuropsychologic tests including the UCLA-Auditory Verbal Learning Test. MRI was performed with a conventional 1.5-tesla scanner. Atrophy was found in many brain structures of demented subjects in comparison with healthy age-matched controls. The volumes of amygdala-hippocampal complexes and of the temporal lobes of demented subjects were more reduced than the total brain volume and other structures. Memory dysfunction was highly correlated with atrophy of the amygdala-hippocampal complexes and of the temporal lobes. Consequently, DAT seems to affect the amygdala-hippocampal complex and their related function (i.e. memory) more than other cerebral structures, but cerebral degeneration in DAT is not restricted to these structures.

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Section: Atrophy O F Amygdala-hippocampal Complexes and Temporal Lobesupporting

confidence: 90%

Amygdala-Hippocampal Atrophy and Memory Performance in Dementia of Alzheimer Type

Heun

Mazanek

Atzor

et al. 1997

Dement Geriatr Cogn Disord

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“…The amygdala is one of the earliest structures to undergo neurodegeneration in AD (Hamann et al, 2002) (Cuenod et al, 1993). It is also involved in the regulation of neural processes that influence affective states such as depression and anxiety, which commonly occur in AD (Molosh et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice

Klein

Acheson

Mace

et al. 2014

Neurobiology of Aging

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The human APOE4 allele is associated with an early age of onset and increased risk of Alzheimer’s disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein-like particle by glial cells in the brain for the primary purpose of transport of lipophilic compounds involved in the maintenance of synapses. Previous studies examining synaptic integrity in the amygdala of human apoE targeted replacement (TR) mice showed a decrease in spontaneous excitatory synaptic activity, dendritic arbor, and spine density associated with apoE4 compared with apoE3 and apoE2 in adult male mice. In the present study, we assessed how APOE genotype affects synaptic integrity of amygdala neurons by comparing electrophysiological and morphometric properties in human apoE3, E4, and E2/4 TR mice at the age of 18–20 months. In contrast to adult mice, we found that aged apoE4 TR mice exhibited the highest level of excitatory synaptic activity compared with other cohorts. Additionally, apoE4 mice had significantly greater spontaneous inhibitory activity than all other cohorts. Taken together, there was a significant interaction between genotypes when comparing inhibition relative to excitation; there was a simple main effect of frequency type with an imbalance toward inhibition in apoE4 mice but not in apoE3 or apoE2/4 mice. These results suggest that apoE isoforms differentially influence synaptic transmission throughout the life span, where aging coupled with apoE4 expression, results in an imbalance in maintaining integrity of synaptic transmission.

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“…The difference of the amygdala and temporal lobe volume between normal healthy controls and Alzheimer's patients was significant (Ftest, N = 11, P < 0.05 to P < 0.0001 resp.) (Cu6nod et al, 1993). Using specific measurements of the temporal horns 22 patients with probable DAT and 49 normal controls were classified correctly 91,5% of the time with a high degree of probability (Willmer et al, 1993).…”

Section: Evaluation Of Specific Areasmentioning

confidence: 99%

“…The hypothesis was that a global measure of brain atrophy would obscure atrophy of specific areas which in turn could be related to less involved areas such as -for example in Alzheimer's dementia -the central motor or sensory strip or the cerebellum. A number of papers published in the past two years were successful with this respect using CT (Willmer et al, 1993) or MRI (Killiany et al, 1993;Cu6nod et al, 1993;Erkinjuntti et al, 1993). Since to quantitatively assess these key areas of early brain atrophy in Alzheimer's disease requires coronal or negative angulation sections for optimal results, the task is best served by MRI.…”

Section: Evaluation Of Specific Areasmentioning

confidence: 99%

Methodological problems and clinical relevance of structural neuroimaging in dementia research

Läng

1995

J. Neural Transmission

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Structural neuroimaging and dementia are conceptually different being only loosely correlated. Computed tomography or magnetic resonance imaging can never "prove" a clinical syndrome such as dementia, but yield clues as to its cause and the site and extent of pathological changes. Conversely, the type and degree of intellectual deterioration can hardly predict neuroradiological findings. The value of structural neuroimaging lies in detecting or excluding possible causes of dementia and quantifying linear or volumetric parameters of tissue and fluid volume. If based on a presumed or established etiology, however, specific neuropsychological and dementia syndromes may correspond to focal pathological changes seen in well-defined cerebral areas as recent investigations have shown with hippocampal atrophy in Alzheimer's dementia.

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Amygdala Atrophy in Alzheimer's Disease

Cited by 163 publications

References 24 publications

Amygdala-Hippocampal Atrophy and Memory Performance in Dementia of Alzheimer Type

Amygdala-Hippocampal Atrophy and Memory Performance in Dementia of Alzheimer Type

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice

Methodological problems and clinical relevance of structural neuroimaging in dementia research

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