AMY1 diploid copy number among end-stage renal disease patients

Grammatikopoulou, Maria G.; Gkiouras, Konstantinos; Markaki, Anastasia; Gkouskou, Kalliopi; Aivaliotis, Michalis; Stylianou, Kostas; Bogdanos, Dimitrios P.

doi:10.1007/s42000-020-00199-6

Cited by 2 publications

(3 citation statements)

References 54 publications

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“…Thereafter, individual nutrient scores were pooled to calculate the total DII score of each patient, based on the 29 aforementioned nutrients. Given that the score of each dietary index is greatly dependent on participants' energy intake, crude DII was regressed on the energy intake, producing an energy adjusted DII score (DIIadj), based on the residual method [39,40]. Given that the score of each dietary index is greatly dependent on participants' energy intake, crude DII was regressed on the energy intake, producing an energy adjusted DII score (DII adj ), based on the residual method [39,40].…”

Section: Energy Expenditure and Dietary Assessmentmentioning

confidence: 99%

Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

et al. 2020

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Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p ≤ 0.001), daytime systolic BP (p ≤ 0.048) and mean carotid β-stiffness index (p ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, p ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.

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Section: Energy Expenditure and Dietary Assessmentmentioning

confidence: 99%

Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

et al. 2020

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“…Thus, the size of our cohort may have been underpowered to detect small differences and future study needs to confirm such association in other populations. Because several previous studies showed no or weak associations with CVD risk factors (e.g., inflammation, obesity, and insulin sensitivity) [ 22 , 24 , 57 ], we might not expect any major association of AMY1 copy number and CVD risk.…”

Section: Discussionmentioning

confidence: 90%

“…A modestly higher postprandial glycemia after a starchy meal has been shown among individuals with high AMY1 copy number compared to those with low AMY1 copy number [15,16], although some studies found no difference [17,18]. In addition, the association between AMY1 copy number and metabolic traits is inconsistent [17,[19][20][21], although a negative association between AMY1 copy number and several cardiometabolic risk factors, including obesity and inflammation which have been shown in some studies, mainly will be small sample sizes [22][23][24]. Thus, there is a need to further explore the association between AMY1 copy number and cardiometabolic risk markers, especially to simultaneously examine a broad range of risk markers, including inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality

Borné

Wang

et al. 2023

BMC Med

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Background Salivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to disease risk is currently rather unknown. The aim was to investigate the association between starch intake and AMY1 copy number and risk of cardiovascular disease (CVD) and mortality and whether there is an interaction. In addition, we aim to identify CVD-related plasma proteins associated with starch intake and AMY1 copy number. Methods This prospective cohort study used data from 21,268 participants from the Malmö Diet and Cancer Study. Dietary data were collected through a modified diet history method and incident CVD and mortality were ascertained through registers. AMY1 gene copy number was determined by droplet digital polymerase chain reaction, a risk score of 10 genetic variants in AMY1 was measured, and a total of 88 selected CVD-related proteins were measured. Cox proportional hazards regression was used to analyze the associations of starch intake and AMY1 copy number with disease risk. Linear regression was used to identify plasma proteins associated with starch intake and AMY1 copy number. Results Over a median of 23 years’ follow-up, 4443 individuals developed CVD event and 8125 died. After adjusting for potential confounders, a U-shape association between starch intake and risk of CVD (P-nonlinearity = 0.001) and all-cause mortality (P-nonlinearity = 0.03) was observed. No significant association was found between AMY1 copy number and risk of CVD and mortality, and there were no interactions between starch intake and AMY1 copy number (P interaction > 0.23). Among the 88 plasma proteins, adrenomedullin, interleukin-1 receptor antagonist protein, fatty acid-binding protein, leptin, and C-C motif chemokine 20 were associated with starch intake after adjusting for multiple testing. Conclusions In this large prospective study among Swedish adults, a U-shaped association between starch intake and risk of CVD and all-cause mortality was found. Several plasma proteins were identified which might provide information on potential pathways for such association. AMY1 copy number was not associated with CVD risk or any of the plasma proteins, and there was no interaction between starch intake and AMY1 copy number on disease risk.

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AMY1 diploid copy number among end-stage renal disease patients

Cited by 2 publications

References 54 publications

Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality

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