AMS 700CX/CXM Inflatable Penile Prosthesis Has High Mechanical Reliability at Long-Term Follow-Up

Abstract

Introduction AMS 700CX/CXM inflatable penile prosthesis is increasingly applied for the treatment of erectile dysfunction (ED). However, there are a few long-term survival data of the inflatable penile prosthesis (IPP) over 10 years. Aim To determine the long-term mechanical reliability of AMS 700CX/CXM inflatable penile prosthesis in patients with ED. Methods A total of 438 consecutive patients with ED received implantation of an AMS 700CX/CXM penile prosthesis at our institution from January 1991 to April 2009. In 397 patients (90.7%), the medical records were available and current status of penile prosthesis could be obtained by a direct telephone interview. The overall and mechanical survival rates of penile prosthesis were evaluated using Kaplan–Meier method. Main Outcome Measures Assessing the mechanical and overall survival rates of the AMS 700CX/CXM penile prosthesis using Kaplan–Meier analysis, and looking for clinical factors related to survival of the CX/CXM using log-rank test. Results Mean age of 397 patients was 63.1 years (range, 24-93) and follow-up duration was 113 months (range 1-219). Eighty-two patients (20.6%) experienced mechanical failure at a median follow-up of 82 months. Mechanical survival rate of the penile prosthesis was 97.6%, 93.2% and 78.2% at 3, 5, and 10 years after implantation, respectively. 12 patients (3.0%) experienced nonmechanical failure including infections, tissue erosion resulting in cylinder protrusion at the meatus and chronic discomfort. Overall survival rate of the penile prosthesis was 95.0%, 91.0% and 75.5% at 3, 5, and 10 years after implantation, respectively. Patients with neurogenic cause for ED showed lower median overall survival of penile prosthesis compared with patients with non-neurogenic cause. Patient age, obesity, and diabetes mellitus had no association with overall survival of penile prosthesis after implantation. Conclusions The AMS 700CX/CXM could be accepted and applied in more patients as a reliable treatment alternative of ED.

Male fertility following spinal cord injury: an update

“…In men with SCI, surgically implanted penile prostheses produced satisfactory results in 60–80% of cases for ED, and in over 90% of cases for urinary (external urinary collecting device) management with 0% perforation rate using an inflatable 3‐piece device (Zermann et al ., ). In a study by Kim et al ., semi‐rigid penile prosthesis was considered as an attractive option because of its low price, less complications, better urinary management, and high satisfaction rate (Kim et al ., ). Educating men with SCI about early signs of penile prosthesis erosion is required because of a lack of penile sensation in the majority of these men.…”

1673 a Population Based Analysis of Contemporary Rates of Reoperation for Penile Prosthesis Procedures

“…Historically, infection rates have been cited as 3-5% 3 , however, rates of less than 1% are often quoted in contemporary single surgeon series 4 . Non-infectious failure rates increase over time, with non-infectious survival rates of 97.6 and 93.2% at 3 and 5 years in a contemporary cohort 5 . However, both infectious and non-infectious survival rates are largely based on single institution, retrospective series and it is unclear if they can be generalized to a larger population of patients.…”

Korean Society for Sexual Medicine and Andrology (KSSMA) Guideline on Erectile Dysfunction

“…Thus, the frequency of mechanical failure of a 3-piece penile prosthesis (AMS 700CX/CXM™ [American Medical Systems, Inc., Minnetonka, MN, USA], Mentor Alpha I™ [Mentor Corp., Santa Barbara, CA, USA]), which has recently been in common use, was reported to be less than 5% in a five-year follow-up study 115,116. In a Korean study that reported the results of a long-term follow-up on a 3-piece penile prosthesis (AMS 700CX/CXM™), the success rates of the penile prosthesis 3 years, 5 years, and 10 years postoperatively were shown to be 95%, 91%, and 75.5%, respectively 117. As infection is a serious complication that requires removal of the prosthesis, both physicians and patients should take precautions.…”