Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

Wu, Zhuoying; Luo, Qianyi; Wu, Huawang; Wu, Zhiyao; Zheng, Yingjun; Yang, Yuling; He, Jianfei; Ding, Yi; Yu, Rongjun; Peng, Hongjun

doi:10.3389/fpsyt.2020.596337

Cited by 16 publications

(19 citation statements)

References 64 publications

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“…Therefore, the deviation of non-specific physiological signal components is smaller (Zou et al, 2008 ). A large amount of neuroimaging evidence has demonstrated abnormal brain function and structure in patients with MDD in the resting state (Lai and Wu, 2015 ; Gray et al, 2020 ; Wu et al, 2020 ; Chase et al, 2021 ; Ebneabbasi et al, 2021 ). A study by Wang et al ( 2012 ) involving 18 first-episode, untreated patients with MDD and 18 healthy controls (HCs) found that patients with MDD had significantly higher fALFF values in the right precentral gyrus, right inferior temporal gyrus, bilateral fusiform gyrus, and bilateral anterior and posterior cerebellar lobes.…”

Section: Introductionmentioning

confidence: 99%

Associations between abnormal spontaneous neural activity and clinical variables, eye movements, and event-related potential indicators in major depressive disorder

Zhang

Yan

et al. 2023

Front. Neurosci.

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BackgroundThis study aimed to investigate the correlations between abnormal spontaneous neural activity measured with fractional amplitude of low-frequency fluctuations (fALFF) and clinical variables, eye movements, and event-related potential indicators in patients with major depressive disorder (MDD).MethodsWe recruited 42 patients with MDD and 42 healthy controls (HCs) and collected their clinical variables, eye movement, event-related potential, and resting-state functional magnetic resonance imaging (rs-fMRI) data. The fALFF, support vector machine (SVM), and correlation analysis were used to analyze the data.ResultsThe results of the study showed that the fALFF values of the sensorimotor network, including the right middle temporal gyrus, right cerebellar Crus2, left occipital gyrus, and left middle temporal gyrus, were significantly higher compared to HCs. Correlation analysis showed that the abnormal fALFF value of the right cerebellar Crus2 was inversely correlated with the active coping scores of the Simplified Coping Style Questionnaire in the patients (r = −0.307, p = 0.048). No correlation was observed between abnormal fALFF values and other clinical symptoms, neuropsychological tests, eye movements, and event-related potential-related indicators in patients with MDD. fALFF values in the left middle temporal gyrus could be used to distinguish patients with MDD from HCs with an accuracy of 78.57%.ConclusionsPatients with MDD exhibited enhanced spontaneous neural activity in the sensorimotor network. No associations were found between abnormal spontaneous neural activity and clinical variables, eye movements, and event-related potential related indicators in MDD.

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Section: Introductionmentioning

confidence: 99%

Associations between abnormal spontaneous neural activity and clinical variables, eye movements, and event-related potential indicators in major depressive disorder

Zhang

Yan

et al. 2023

Front. Neurosci.

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“…Subsequent frequency-specific studies demonstrated that functional alterations in Parkinson’s disease were more prominent in slow-4 ( Liao et al, 2021 ), while in Alzheimer’s disease, slow-5 can be more sensitive ( Han et al, 2011 ). However, more studies suggested the two frequency bands offer complementary information ( Wu et al, 2020 ; Yang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Frequency-dependent functional alterations in people living with HIV with early stage of HIV-associated neurocognitive disorder

Wang

Liú²,

Wang³

et al. 2023

Front. Neurosci.

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BackgroundHIV enters the brain soon after seroconversion and causes HIV-associated neurocognitive disorder (HAND). However, the pathogenesis of this insidious impairment at an early stage remains unclear.ObjectivesTo explore functional integration and segregation changes at the early stages of HAND, voxel-level indices of regional homogeneity (ReHo), the amplitude of low-frequency fluctuations (ALFF), and voxel-mirrored homotopic connectivity (VMHC) under two different frequency bands (slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed.MethodsNinety-eight people living with HIV (PLWH) and 44 seronegative controls underwent resting-state functional magnetic resonance imaging. Furthermore, all PLWHs underwent neuropsychological and daily functioning tests. The main effect of the group and the interaction between the group and frequency band were investigated. Finally, the relationship between the altered indices and the cognitive domains was explored.ResultsA significant group-by-frequency interaction was demonstrated in the right thalamus for ReHo; for VMHC, the interaction was observed in the bilateral precuneus and paracentral gyrus. The post hoc Bonferroni test indicated that the alteration of ReHo and VMHC could only be detected in slow-5. PLWH showed significantly reduced ALFF in both the frequency bands in the right occipital gyrus and right calcarine. Moreover, some altered functional integration and segregation indices are related to impaired cognitive function.ConclusionPeople living with HIV displayed aberrant functional integration and segregation at the early stages of HAND, which is linked to cognitive function. The frequency band of slow-5 might be more sensitive for detecting insidious damage at an early stage.

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“…Recently, resting-state functional magnetic resonance imaging (rs-fMRI) has played an important role in studying brain functional activity as a safe, noninvasive technique, which reflects neural activity via blood oxygen level-dependent (BOLD) signals (Mosier et al, 1999 ; Mosier and Bereznaya, 2001 ; Suzuki et al, 2003 ; Zhang et al, 2020 ; Ma et al, 2021 ). Amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) are two classic local indices of rs-fMRI, which are widely used due to good stability (Qiu et al, 2019 ; Wu et al, 2020 ). ALFF has been calculated as the mean amplitude of the BOLD signal deviating from baseline over a short period of time, reflecting the strength of the spontaneous neural activity in voxels (Zang et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Repetitive Transcranial Magnetic Stimulation of Cerebellar Swallowing Cortex on Brain Neural Activities: A Resting-State fMRI Study

Dong

Wang

et al. 2022

Front. Hum. Neurosci.

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ObjectiveThe effects and possible mechanisms of cerebellar high-frequency repetitive transcranial magnetic stimulation (rTMS) on swallowing-related neural networks were studied using resting-state functional magnetic resonance imaging (rs-fMRI).MethodA total of 23 healthy volunteers were recruited, and 19 healthy volunteers were finally included for the statistical analysis. Before stimulation, the cerebellar hemisphere dominant for swallowing was determined by the single-pulse TMS. The cerebellar representation of the suprahyoid muscles of this hemisphere was selected as the target for stimulation with 10 Hz rTMS, 100% resting motor threshold (rMT), and 250 pulses, with every 1 s of stimulation followed by an interval of 9 s. The motor evoked potential (MEP) amplitude of the suprahyoid muscles in the bilateral cerebral cortex was measured before and after stimulation to evaluate the cortical excitability. Forty-eight hours after elution, rTMS was reapplied on the dominant cerebellar representation of the suprahyoid muscles with the same stimulation parameters. Rs-fMRI was performed before and after stimulation to observe the changes in amplitude of low-frequency fluctuation (ALFF) and regional homology (ReHo) at 0.01–0.08 Hz, 0.01–0.027 Hz, and 0.027–0.073 Hz.ResultsAfter cerebellar high-frequency rTMS, MEP recorded from swallowing-related bilateral cerebral cortex was increased. The results of rs-fMRI showed that at 0.01–0.08 Hz, ALFF was increased at the pons, right cerebellum, and medulla and decreased at the left temporal lobe, and ReHo was decreased at the left insular lobe, right temporal lobe, and corpus callosum. At 0.01–0.027 Hz, ALFF was decreased at the left temporal lobe, and ReHo was decreased at the right temporal lobe, left putamen, and left supplementary motor area.ConclusionRepetitive transcranial magnetic stimulation of the swallowing cortex in the dominant cerebellar hemisphere increased the bilateral cerebral swallowing cortex excitability and enhanced pontine, bulbar, and cerebellar spontaneous neural activity, suggesting that unilateral high-frequency stimulation of the cerebellum can excite both brainstem and cortical swallowing centers. These findings all provide favorable support for the application of cerebellar rTMS in the clinical practice.

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Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

Cited by 16 publications

References 64 publications

Associations between abnormal spontaneous neural activity and clinical variables, eye movements, and event-related potential indicators in major depressive disorder

Associations between abnormal spontaneous neural activity and clinical variables, eye movements, and event-related potential indicators in major depressive disorder

Frequency-dependent functional alterations in people living with HIV with early stage of HIV-associated neurocognitive disorder

The Effect of Repetitive Transcranial Magnetic Stimulation of Cerebellar Swallowing Cortex on Brain Neural Activities: A Resting-State fMRI Study

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