Amplitude of Evoked Responses to Tones of High Intensity

Picton, Terence W.; Goodman, Wilfred S.; Bryce, Douglas P.

doi:10.3109/00016487009181862

Cited by 85 publications

(41 citation statements)

References 18 publications

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“…Interestingly, although it has been reported that these intensity growth functions can asymptote at higher intensity levels [Adler and Adler, 1989;Picton et al, 1970], we did not observe such a plateau in our data. This is likely due to the longer ISI used in the present study.…”

Section: Effect Of Intensitycontrasting

confidence: 54%

“…This is likely due to the longer ISI used in the present study. Picton et al [1970] found that intensity function asymptotes were only present at shorter ISIs.…”

Section: Effect Of Intensitymentioning

confidence: 95%

“…As mentioned previously, amplitude increases and latency decreases with increases in stimulus intensity; however, there are reports in the literature of an asymptote in latency and amplitude intensity functions occurring at about 70 dB in normal-hearing listeners Adler, 1989, 1991;Picton et al, 1970]. The stimulus intensity used in the previous study was 64 dB peSPL, a level close to the 70-dB asymptote point; therefore, it is possible that the effect of amplification on amplitude and latency would be reduced or absent as a result of saturation characteristics of neural activity at high intensities.…”

Section: Introductionmentioning

confidence: 91%

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Effects of Hearing Aid Amplification and Stimulus Intensity on Cortical Auditory Evoked Potentials

et al. 2007

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Hearing aid amplification can be used as a model for studying the effects of auditory stimulation on the central auditory system (CAS). We examined the effects of stimulus presentation level on the physiological detection of sound in unaided and aided conditions. P1, N1, P2, and N2 cortical evoked potentials were recorded in sound field from 13 normal-hearing young adults in response to a 1000-Hz tone presented at seven stimulus intensity levels. As expected, peak amplitudes increased and peak latencies decreased with increasing intensity for unaided and aided conditions. However, there was no significant effect of amplification on latencies or amplitudes. Taken together, these results demonstrate that 20 dB of hearing aid gain affects neural responses differently than 20 dB of stimulus intensity change. Hearing aid signal processing is discussed as a possible contributor to these results. This study demonstrates (1) the importance of controlling for stimulus intensity when evoking responses in aided conditions, and (2) the need to better understand the interaction between the hearing aid and the CAS.

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Section: Effect Of Intensitycontrasting

confidence: 54%

“…This is likely due to the longer ISI used in the present study. Picton et al [1970] found that intensity function asymptotes were only present at shorter ISIs.…”

Section: Effect Of Intensitymentioning

confidence: 95%

Section: Introductionmentioning

confidence: 91%

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Effects of Hearing Aid Amplification and Stimulus Intensity on Cortical Auditory Evoked Potentials

et al. 2007

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“…This may also be explained by the contamination by early components (N 1 , P 2 ), which seem to be differently sensitive to intensity changes. The N 1 amplitude increases with increasing stimulus intensity [Rapin et al, 1966;Beagley and Knight, 1967;Picton et al, 1970] which most likely affected the louder deviant comparisons. Further studies along these lines should therefore use descending intensity deviants to avoid this contamination.…”

Section: Discussionmentioning

confidence: 99%

Preattentive Memory-Based Comparison of Sound Intensity

Jacobsen¹,

Horenkamp²,

Schröger³

2003

Audiol Neurotol

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Changes in the intensity of repeated, ignored sounds elicit the mismatch negativity (MMN) brain response which reflects preattentive detection of the change. It is generally assumed that the MMN in response to intensity changes reflects a memory-based comparison mechanism rather than being due to differential states of refractoriness of intensity-specific cortical neurons. In the present study, an experimental protocol consisting of 4 oddball blocks and 1 control block was used in order to separate memory-comparison-related effects from refractoriness-related ones. This design allowed an assessment of intensity MMN using physically identical stimuli with equal probability of occurrence in separate blocks, while avoiding contamination by refractoriness. Results were consistent with an MMN in response to intensity change that reflects genuine memory-based comparison.

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“…Although AER amplitude generally increases with increasing stimulus intensity (AER 'augmenting'), individual differences in the degree of increment are prominent; many people actually show a decrease in amplitude with increasing stimulus intensity (AER 're ducing'). This has been found both in auditory [Picton et al, 1970] and visual AERs [Buchsbaum and P fefferba um , 1971; V a u g h a n and H u l l , 1965], Decreases in amplitude with increasing stimulus intensity appear related to central neural factors; they do not reflect only peripheral ad justment mechanisms [Buchsbaum and P fefferbaum, 1971; in press].…”

Section: Discussionmentioning

confidence: 99%

Effects of Carbohydrate-Active Steroids and ACTH on Visually-Evoked Responses in Patients with Adrenal Cortical Insufficiency

Buchsbaum¹,

Henkin²

1975

Neuroendocrinology

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Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were of small amplitude and short latency. Treatment with ACTH alone decreased the amplitude/intensity response, suggesting extra-adrenal effects. Both with amplitude and latency effects, stimulus intensity was an important parameter in determining steroid and ACTH effects.

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Amplitude of Evoked Responses to Tones of High Intensity

Cited by 85 publications

References 18 publications

Effects of Hearing Aid Amplification and Stimulus Intensity on Cortical Auditory Evoked Potentials

Effects of Hearing Aid Amplification and Stimulus Intensity on Cortical Auditory Evoked Potentials

Preattentive Memory-Based Comparison of Sound Intensity

Effects of Carbohydrate-Active Steroids and ACTH on Visually-Evoked Responses in Patients with Adrenal Cortical Insufficiency

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