Amplitude and area ratios of summating potential/action potential (SP/AP) in Meniere's disease

Baba, Akiko; Takasaki, Kenji; Tanaka, Fujinobu; Tsukasaki, Naoki; Kumagami, Hidetaka; Takahashi, Haruo

doi:10.1080/00016480701724888

Cited by 21 publications

(27 citation statements)

References 16 publications

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“…Especially MD had a high incidence of 57.6%, almost the same as reported by Baba et al [9] . However, the value was relatively low compared with the previously reported high incidence of 71-76.1% [5][6][7] .…”

Section: Discussionsupporting

confidence: 76%

“…As to the recording technique, the transtympanic technique was introduced to yield a good output and signalto-noise ratio in addition to the less invasive extratympanic and tympanic techniques. However, although there are some conflicting arguments, the incidence of an enhanced SP is no more than 55-75% even in confirmed cases of MD [5][6][7][8][9] . This means that endolymphatic hydrops does not always result in enhancement of the SP.…”

Section: Introductionmentioning

confidence: 99%

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The Clinical Value of Extratympanic Electrocochleography in the Diagnosis of Ménière’s Disease

Takeda

Kakigi

2010

ORL

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Objective: To evaluate the clinical conditions causing an elevation in the click-evoked summation potential (SP)/action potential (AP) amplitude ratio (SP/AP ratio), the cause of the SP enhancement in Ménière’s disease (MD) and the diagnostic efficacy of electrocochleography (ECoG) were discussed. Study Design: Retrospective case review. Setting: An outpatient clinic of the Otolaryngology Department of Kochi Medical School. Patients: ECoG testing was performed in 632 patients (727 ears) with vertigo/dizziness and/or deafness over a 10-year period (1995–2005). Among them, 334 patients had diagnoses of definite MD, including 95 cases of bilateral involvement. Main Outcome Measures: Audiological thresholds and SP/AP ratio. Results: An enhanced SP was observed in 56.3% of patients with MD. The incidence of an enhanced SP was low in patients for whom the disease duration was 2 years or less and the frequency of attacks was once a year or less, but was significantly higher in cases where the disease duration was 2 years or longer and/or the frequency of attacks was several times a year (Games-Howell test, p < 0.05). The incidence of an enhanced SP was significantly elevated in cases with pure-tone average exceeding 31 dB (Kendall’s rank correlation test, p < 0.001). However, the enhanced SP, once it appeared, did not always disappear in spite of hearing improvement. Hearing improvement induced by the glycerol test also produced no alteration in an SP/AP ratio, and there was no significant difference between the glycerol test results and the incidence of an enhanced SP (χ² goodness-of-fit test). Conclusions: The longer the patients were symptomatic or the severer the ear symptoms, the more likely the ECoG was to be positive. The abnormally elevated SP, once it had appeared, persisted for long periods. Spontaneous and glycerol-induced hearing gains did not result in a decrease in SP/AP ratio. These clinical characteristics of ECoG seem to indicate that the enhanced SP in MD might be caused by the malfunction of hair cells, not by the displacement of the basilar membrane toward the scala tympani.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

The Clinical Value of Extratympanic Electrocochleography in the Diagnosis of Ménière’s Disease

Takeda

Kakigi

2010

ORL

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“…With respect to SP/AP AUC, they found 43.9%, 27.7%, and 30% respectively, concluding that the analysis of SP/AP AUC with transtympanic electrocochleography does not necessarily increase the sensitivity in the diagnosis of endolymphatic hydrops compared with SP/AP amplitude. 25 Ikino et al used transtympanic electrocochleography to examine 21 patients with definite Ménière's disease and 19 normal hearing patients with other cochleovestibular disorders. They compared SP/AP, AP latency difference, and area under curve of SP/AP ratio and calculated the diagnostic sensitivity of these parameters.…”

Section: Discussionmentioning

confidence: 99%

Electrocochleography for Ménière's disease: is it reliable?

Lamounier

Gobbo

Souza

et al. 2014

Brazilian Journal of Otorhinolaryngology

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“…Lamounier et al also found in the systematic review that the analysis of the SP/AP ratio curve of the transtympanic electrocochleography did not necessarily increase sensitivity in the diagnosis of hydrops when compared with the SP/AP amplitude [14,[16][17][18].…”

Section: Electrocochleography (Ecochg)mentioning

confidence: 99%

“…In most studies selected, the transtympanic electrode is the most widely used. EcochG in MD presents a variable sensitivity, as in cases of hearing loss due to disease progression, patients may experience a reduction in the amplitude of AP due to loss of auditory nerve fibers [14][15][16][17].…”

Section: Electrocochleography (Ecochg)mentioning

confidence: 99%

Electrophysiology in Ménière’s Disease

Lamounier¹

2017

Up to Date on Meniere's Disease

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Ménière's disease (MD) is a progressive inner ear disorder that affects at least 0.2% of the population in EUA. The symptoms triad of fluctuating hearing loss, tinnitus, and vertigo was described by Prosper Ménière for more than a century and its pathophysiology is still unknown. MD has a fluctuating course and in many cases, difficult clinical management. Progressive hearing loss and intense dizzying seizures becomes more frequent as the disease progresses. All of this increases the challenges of accurate identification and has probably led to the trial of several tests for identifying MD. The tests are useful tools to assist the otolaryngologist both in diagnosis and prognosis of MD. These tests includes audiometry, otoacustic emission (OAE), electrocochleography (EcochG), vestibular evoked myogenic potentials (VEMP), cochlear hydrops analysis masking procedure (CHAMP) and video head impulse test (vHIT).

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Amplitude and area ratios of summating potential/action potential (SP/AP) in Meniere's disease

Cited by 21 publications

References 16 publications

The Clinical Value of Extratympanic Electrocochleography in the Diagnosis of Ménière’s Disease

The Clinical Value of Extratympanic Electrocochleography in the Diagnosis of Ménière’s Disease

Electrocochleography for Ménière's disease: is it reliable?

Electrophysiology in Ménière’s Disease

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