Amplifying and Suppressive Effect of Thymus Cells

Droege, W.

doi:10.1038/234549a0

Cited by 92 publications

(38 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TGF-β is also involved in the generation and function of T regulatory cells (T regs ) (26,27), which suppress physiological and pathological immune responses and prevent autoimmune disease (28)(29)(30). Interestingly, previous studies have shown greater immunosuppressive activity of T regs associated with CNS tumors (31)(32)(33).…”

mentioning

confidence: 99%

T-cell TGF-β signaling abrogation restricts medulloblastoma progression

Gate

Danielpour

Rodríguez

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Cancer cell secretion of TGF-β is a potent mechanism for immune evasion. However, little is known about how central nervous system tumors guard against immune eradication. We sought to determine the impact of T-cell TGF-β signaling blockade on progression of medulloblastoma (MB), the most common pediatric brain tumor. Genetic abrogation of T-cell TGF-β signaling mitigated tumor progression in the smoothened A1 (SmoA1) transgenic MB mouse. T regulatory cells were nearly abolished and antitumor immunity was mediated by CD8 cytotoxic T lymphocytes. To define the CD8 T-cell subpopulation responsible, primed CD8 T cells were adoptively transferred into tumor-bearing immunocompromised SmoA1 recipients. This led to generation of CD8 + / killer cell lectin-like receptor G1 high (KLRG1 hi )/IL-7R lo short-lived effector cells that expressed granzyme B at the tumor. These results identify a cellular immune mechanism whereby TGF-β signaling blockade licenses the T-cell repertoire to kill pediatric brain tumor cells.cancer immunology | neuroimmunology | neuro-oncology

show abstract

mentioning

confidence: 99%

T-cell TGF-β signaling abrogation restricts medulloblastoma progression

Gate

Danielpour

Rodríguez

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…It is rapidly becoming clear that in certain antibody responses thymus-derived lymphocytes (T cells) are definitely endowed with a role to suppress responses of bone marrow-derived lymphocytes (B cells) to antigen (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Such inhibitory effect of T cells led to a designation of "suppressor T cell" and is being recognized in large measure as an important regulatory device in various antibody responses.…”

mentioning

confidence: 99%

Selective Roles of Thymus-Derived Lymphocytes in the Antibody Response

Tada

Takemori

1974

The Journal of Experimental Medicine

View full text Add to dashboard Cite

It is rapidly becoming clear that in certain antibody responses thymus-derived lymphocytes (T cells) are definitely endowed with a role to suppress responses of bone marrow-derived lymphocytes (B cells) to antigen (1-12). Such inhibitory effect of T cells led to a designation of "suppressor T cell" and is being recognized in large measure as an important regulatory device in various antibody responses. Some forms of immunological tolerance are also explained by the active suppression by T cells rather than the elimination of B-cell clones (12)(13)(14).The suppression by T cells has been shown to be mediated by both antigenspecific and nonspeclfiC mechanisms, while both pathways may be equally important for the regulation of antibody synthesis. Our previous studies (3) demonstrated that T cells primed with a carrier antigen suppressed an ongoing IgE antibody synthesis by B cells against a hapten coupled to the same carrier; thus this suppression appeared to be antigen-specific. The presence of a subcellular component of T cells that specifically suppresses the B-cell response was also reported (15).Our more recent studies on the specific suppression of IgM antibody response by T cells (11) showed another important fact, namely, that the T cell's suppressive effect on B cells varied depending on the time when the suppressor cells were given to the immunized recipients. The suppressor effect on the IgM antibody response was found to be more pronounced if the primed T cells were given to the recipients at a time when antibody-forming cells were starting to appear in their spleen rather than at the time of immunization. These observations suggest that the susceptibility of B cells to the suppressive effect of T cells is inherently different depending on the maturation stage of B cells and on the immunoglobulin classes which they are destined to produce. The present experiments were undertaken to study the mode and sites of action of suppressor T cells on antibody response in mice with special reference to the differential effect of T cells on B cells which produce IgM and IgG antibodies.

show abstract

“…The skin was grafted to WC recipients underneath the wing as shown in Figs. [2][3][4]. The grafts were sealed with Histoacryl-Blau (Braun, Melsungen, Germany), covered with a thin film of nobecutan (Bofors, Nobel-Pharma, Sweden) and protected for the first 5 days with 12 X 2 cm bandage (Beiersdorf, Hamburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…2). The grafts were checked every second day for the first 4 weeks, and once a week for grafts surviving more than 30 days. Three types of results were observed: (1) acute necrosis (identified by the black color of the graft) starting on average 7 days after grafting and leading to complete rejection around day 15; (2) the chronic rejection process which is indicated by a dry, yellow surface of the graft; and (3) the long-lasting graft survival.…”

Section: Methodsmentioning

confidence: 99%

“…1-3). In the chicken, thymus cells given together with antigen were found to suppress the serum antibody titers against this antigen (4), and also the number of plaque-forming cells in the spleen (W. Droege, unpublished). Experiments suggest that this suppression is mediated by a cell type (suppressor cell) which is different from typical B-cells as well as T-cells, and which in chickens is found predominantly in the young thymus (5,6).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Immunosuppressive Effect of Syngeneic Thymus Cells on Allograft Rejection

Droege¹

1975

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

Transfer of thymus cells from young chickens to syngeneic recipients suppresses the allograft rejection between strains differing at the major histocompatibility (B) locus. Thymus cell transfer in combination with a light whole body irradiation (360 R) prolongs significantly the mean rejection time of skin allografts and leads in a proportion of recipients to long-lasting graft survival (>200 days). Three weeks after the cell transfer, the suppression appears to be antigen specific, as judged by the normal reactivity against third-party skin grafts. From the types of thymus cell preparations that are effective in these experiments, it is inferred that the suppressor cell is a bursa-dependent lymphocyte, which is predominantly found in the young chicken thymus and which is different from B-lymphocytes, B-precursor cells, or graft-versus-host-reactive T-cells.

show abstract

Amplifying and Suppressive Effect of Thymus Cells

Cited by 92 publications

References 12 publications

T-cell TGF-β signaling abrogation restricts medulloblastoma progression

T-cell TGF-β signaling abrogation restricts medulloblastoma progression

Selective Roles of Thymus-Derived Lymphocytes in the Antibody Response

Immunosuppressive Effect of Syngeneic Thymus Cells on Allograft Rejection

Contact Info

Product

Resources

About