Amplification/overexpression of Aurora-A in human gastric carcinoma: Potential role in differentiated type gastric carcinogenesis

Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway

“…12 Its overexpression was reported in various malignancies, including breast, colorectal, pancreatic and gastric cancer. [18][19][20] In this study, we showed that Aurora-A is overexpressed in ovarian cancer cells compared to OSEs. In addition, we showed that variants II and V are predominant.…”

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation

“…Aurora-A is frequently amplified in several human cancers and overexpression of Aurora-A has been detected in 94% of invasive duct adenocarcinomas of the breast (Bischoff et al, 1998;Zhou et al, 1998;Tanaka et al, 1999Tanaka et al, , 2005Kamada et al, 2004;Giet et al, 2005;Hu et al, 2005). However, the causal relationship between overexpression of Aurora-A and tumorigenesis is not fully established due to contradictory data obtained from different experimental systems (Bischoff et al, 1998;Zhou et al, 1998;Anand et al, 2003;Zhang et al, 2004).…”

“…Aurora-A is frequently overexpressed in various cancers, including breast, colorectal, pancreatic, ovarian, esophagel, gastric and bladder cancers (Bischoff et al, 1998;Zhou et al, 1998;Tanaka et al, 1999Tanaka et al, , 2005Kamada et al, 2004;Giet et al, 2005;Hu et al, 2005). It was demonstrated that overexpression of Aurora-A was sufficient to transform NIH3T3 and immortalized Rat-1 cells and that the transformed cells could form tumors when implanted in nude mice (Bischoff et al, 1998;Zhou et al, 1998).…”

Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues

“…[23][24][25][26][27] In addition, most of the primary invasive mammary carcinomas analyzed for Aurora-A immunoreactivity were found to be strongly positive. 28 A significant overexpression of Aurora-B has been described in human cancer cell lines, and a correlation between Aurora-B expression levels and Duke's grade in colorectal tumors has been described. 29,30 Concerning the thyroid tissue, only Aurora-B expression has been recently investigated in a single report and showed to be present in normal tissue and upregulated in undifferentiated thyroid cancer cells and tissues.…”