Amplification of the anonymous marker D17S67 in malignant astrocytomas

Ek, Bijlsma; Leenstra, Sieger; Westerveld, A.; Da, Bosch; Tj, Hulsebos

doi:10.1002/gcc.2870090213

Cited by 13 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only in one highgrade astrocytoma we found a 3.5-fold amplification of GOA (GBM 1683, data not shown), suggesting that amplification of this gene is not a frequent event in astrocytomas. This tumor was known to harbor multiple amplification events on chromosome 17 (9).…”

Section: Expression Of Goa In Astrocytomas Andmentioning

confidence: 98%

See 1 more Smart Citation

GOA, a Novel Gene Encoding a Ring Finger B-Box Coiled-Coil Protein, Is Overexpressed in Astrocytoma

Vandeputte

Meije

Dartel

et al. 2001

Biochemical and Biophysical Research Communications

Self Cite

View full text Add to dashboard Cite

Section: Expression Of Goa In Astrocytomas Andmentioning

confidence: 98%

“…The GOAspecific test probe was a 1470-bp insert of IMAGE clone 2162284, containing the 3Ј half of GOA. Probes were labeled as described for the Northern blotting procedure and hybridized under conditions given previously (9).…”

Section: Southern Blot Analysismentioning

confidence: 99%

GOA, a Novel Gene Encoding a Ring Finger B-Box Coiled-Coil Protein, Is Overexpressed in Astrocytoma

Vandeputte

Meije

Dartel

et al. 2001

Biochemical and Biophysical Research Communications

Self Cite

View full text Add to dashboard Cite

“…Previous genetic studies of malignant astrocytomas have identi ed regions of oncogene activation (most commonly gene ampli cation of EGFR at 7p12) (Bello et al, 1994;Bijlsma et al, 1994;Fischer et al, 1994;Leenstra et al, 1994;Muleris et al, 1994;Schrock et al, 1996;von Deimling et al, 1994) as well as tumor suppressor gene inactivation as de ned by LOH. LOH has been reported in gliomas at 9p (MTS1/CDKN2A and MTS2/CDKN2B), 13q (RB), Neuro-Oncology n JU LY 19 9 9 170 E.C.…”

mentioning

confidence: 99%

A study of loss of heterozygosity at 70 loci in anaplastic astrocytoma and glioblastoma multiforme with implications for tumor evolution

Wooten¹,

Fults²,

Duggirala³

et al. 1999

Neuro-Oncol

View full text Add to dashboard Cite

Cancers that arise from astrocytes in the adult CNS present as either anaplastic astrocytomas (AAs) or as more aggressive glioblastomas multiforme (GBMs). GBMs either form de novo or progress from AAs. We proposed to examine the molecular genetic relationship between these CNS tumors by conducting a genome-wide allelic imbalance analysis that included 70 loci on examples of AA and GBM. We found signi cant loss of heterozygosity (LOH) at 13 discrete chromosomal loci in both AAs and GBMs. Loss was signi cant in both AAs and GBMs at 9 of these loci. AAs show the highest rates of LOH at chromosomes 1p, 4q, 6p, 9p, 11p, 11q, 13q, 14q, 15p, 17p, 17q, and 19q. GBMs showed the greatest losses at 1p, 6q, 8p, 9p, 10p, 10q, 11p, 13q, 17p, 17q, 18p, 18q, and 19q. GBMs also demonstrated signi cant ampli cation at the epidermal growth factor receptor locus (7p12). These data suggest that there are three classes of loci involved in glioma evolution. First are loci that are likely involved in early events in the evolution of both AAs and GBMs. The second class consists of AA-speci c loci, typi ed by higher LOH frequency than observed in GBMs (4q, 6p, 17p, 17q, 19q). The third class consists of GBM-speci c loci (6q, 8p, 10, 18q). Damage at these loci may either lead to de novo GBMs or permit existing AAs to progress to GBMs. Glioma-related LOH pro les may have prognostic implications that could lead to better diagnosis and treatment of brain cancer patients. Neuro-Oncology 1, 169-176, 1999 (Posted to Neuro-Oncology [serial online], Doc. 98-28, June 16, 1999

show abstract

“…While 17p and 19q13 have been suggested to be important in osteosarcoma by conventional cytogenetics, these regions may be aå ected in higher percentages of osteosarcoma specimens than previously suggested. 17p ampli cation also has been reported in malignant astrocytoma [ 32] . While no speci c gene targets within the 19q12-13 region have been identi ed, candidate genes include AKT2, a gene encoding a Ser/Thr kinase ; ERCC2, a DNA repair gene ; BCL3 that encodes a transcriptional regulator of NFi b ; and TGFb, a gene involved in mesenchymal diå erentiation [33][34][35][36] .…”

Section: Discussionmentioning

confidence: 80%

Cytogenetic Findings in 36 Osteosarcoma Specimens and a Review of the Literature

Boehm¹

2000

Pediatric Pathology & Molecular Medicine

View full text Add to dashboard Cite

chromosomal abnormalities have been shown to characterize certain subg roups of & T umor-speci c mesenchymal neoplasms. Identi cation of these abnormalities has proven useful diagnostically and has provided direction for molecular studies of pathogenetically important genes. Recent studies focusing on cytog enetic and molecular cytog enetic nding s in osteosarcoma have expanded our knowledge of chromosomal alterations in this neoplasm and are pointing to recurrent reg ions of interest. In our study, the cytog enetic ndings of 36 osteosarcoma specimens and a review of the literature ( f or a total of 161 specimens) are provided. M olecular cytog enetic studies were performed on two specimens. Clonal chromosomal abnormalities were detected in 25 of 36 specimens and included 17 near-diploid, 8 near-triploid, 2 near-tetraploid, and 8 specimens with multiple clones of diå erent ploidy levels. Examination of the present data and previously published results reveals that chromosomal bands or reg ions 1p11-13, 1q11-12, 1q21-22, 11p14-15, 14p11-13, 15p11-13, 17p, and 19q13 are most f requently rearranged, and the most common numerical abnormalities are + 1, -9, -10, -13, and -17. T he majority of osteosarcomas examined were characterized by complex karyotypes.

show abstract

Amplification of the anonymous marker D17S67 in malignant astrocytomas

Cited by 13 publications

References 16 publications

GOA, a Novel Gene Encoding a Ring Finger B-Box Coiled-Coil Protein, Is Overexpressed in Astrocytoma

GOA, a Novel Gene Encoding a Ring Finger B-Box Coiled-Coil Protein, Is Overexpressed in Astrocytoma

A study of loss of heterozygosity at 70 loci in anaplastic astrocytoma and glioblastoma multiforme with implications for tumor evolution

Cytogenetic Findings in 36 Osteosarcoma Specimens and a Review of the Literature

Contact Info

Product

Resources

About