Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

Mokrousov, Maksim D.; Новоселова, М. В.; Nolan, Jackie; Harrington, Walter N.; Rudakovskaya, Polina G.; Bratashov, Daniil N.; Galanzha, Ekaterina I.; Fuenzalida‐Werner, Juan Pablo; Yakimov, Boris P.; Nazarikov, Gleb; Drachev, Vladimir P.; Shirshin, Evgeny A.; Ntziachristos, Vasilis; Stiel, André C.; Zharov, Vladimir P.; Gorin, Dmitry A.

doi:10.1364/boe.10.004775

Cited by 30 publications

(27 citation statements)

References 30 publications

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“…The chromophore role can play inorganic nanoparticles like gold, magnetite nanoparticles, or fluorescent dyes like indocyanine green. [262,264,266,305] It is necessary to remark that indocyanine green is already FDA improved for clinical applications. [365] The presence of magnetite nanoparticle in the shell provides an opportunity to realize the MRI contrast in both T1 and T2 modes, as well as navigation mode obtained by the magnetic field gradient.…”

Section: Discussionmentioning

confidence: 99%

“…[261] Then, numerous investigations on the use of LbL assembly were described to successfully obtain microcapsules as contrast agents for PA, FL, and MRI modalities with micrometer and sub-micrometer size. [262][263][264][265][266] To the best of our knowledge, there is no commercially available contrast agent based on LbL microcapsules; still, the possibility of multimodal microcapsules preparation is significantly increased with the use of the LbL assembly. Finding a convenient way to produce such contrast agents is one of the most intriguing questions.…”

Section: Basic Principles Of Core-shell Structure Preparation and Functionalizationmentioning

confidence: 99%

“…[265] Therefore, a bimodal contrast agent based on the selfquenching of IGC encapsulated in a biodegradable polymer shell was obtained in a similar manner, as can be seen in Figure 18c. [264] Using both FIL and LbL assembly, PA /fluorescent contrast agent achieved an increase in a local ICG concentration.…”

Section: Layer-by-layer Assembly: Preparation and Functionalization Of Core-shell Structuresmentioning

confidence: 99%

“…c) Reproduced with permission. [ 264 ] Copyright 2019, The Optical Society. d) Reproduced under the terms of the CC‐BY Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).…”

Section: Core–shell Structures For Biomedical Applicationsmentioning

confidence: 99%

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Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.

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Section: Discussionmentioning

confidence: 99%

Section: Basic Principles Of Core-shell Structure Preparation and Functionalizationmentioning

confidence: 99%

Section: Layer-by-layer Assembly: Preparation and Functionalization Of Core-shell Structuresmentioning

confidence: 99%

Section: Core–shell Structures For Biomedical Applicationsmentioning

confidence: 99%

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Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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“…The readers of this special issue will find a number of original manuscripts related to Optical Coherence Tomography [13,14], Optoacoustics/Photoacoustics [15,16], and optonanotechnology [17,18]. The issue also includes 3 invited reviews including from Prof. Schneckenburger: "Working in the fields of Biomedical Spectroscopy and Microscopy I felt myself inspired by Valery Tuchin to extend my work to Laser Micromanipulation.…”

mentioning

confidence: 99%

Recent progress in optical probing and manipulation of tissue: introduction

Larin¹,

Zhu²,

Priezzhev³

et al. 2019

Biomed. Opt. Express

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This feature issue of Biomedical Optics Express represents a cross-section of the most recent work in tissue optics, including exciting developments in tissue optical clearing, deep tissue imaging, optical elastography, nanophotonics in tissue, and therapeutic applications of light, amongst others. A collection of 33 papers provides a comprehensive overview of current research in tissue optics, much of it inspired and informed by the pioneering work of Prof. Valery Tuchin. The issue contains three invited manuscripts and several mini-reviews that we hope will benefit researchers in this exciting area.

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DNA‐Based Nanocarriers to Enhance the Optoacoustic Contrast of Tumors In Vivo

Joseph

Baumann

Postigo

et al. 2020

Adv Healthcare Materials

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Optoacoustic tomography (OT) enables non‐invasive deep tissue imaging of optical contrast at high spatio‐temporal resolution. The applications of OT in cancer imaging often rely on the use of molecular imaging contrast agents based on near‐infrared (NIR) dyes to enhance contrast at the tumor site. While these agents afford excellent biocompatibility and minimal toxicity, they present limited optoacoustic signal generation capability and rapid renal clearance, which can impede their tumor imaging efficacy. In this work, a synthetic strategy to overcome these limitations utilizing biodegradable DNA‐based nanocarrier (DNA‐NC) platforms is introduced. DNA‐NCs enable the incorporation of NIR dyes (in this case, IRDye 800CW) at precise positions to enable fluorescence quenching and maximize optoacoustic signal generation. Furthermore, these DNA‐NCs show a prolonged blood circulation compared to the native fluorophores, facilitating tumor accumulation by the enhanced permeability and retention (EPR) effect. In vivo imaging of tumor xenografts in mice following intravenous administration of DNA‐NCs reveals enhanced OT signals at 24 h when compared to free fluorophores, indicating promise for this method to enhance the optoacoustic signal generation capability and tumor uptake of clinically relevant NIR dyes.

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Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

Cited by 30 publications

References 30 publications

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

Recent progress in optical probing and manipulation of tissue: introduction

DNA‐Based Nanocarriers to Enhance the Optoacoustic Contrast of Tumors In Vivo

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