Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

Kim, Hyungsup; Kim, Hyesu; Nguyen, Luan Thien; Ha, Tae-Woong; Lim, Seung Woon; Kim, Kyungmin; Kim, Soon Ho; Han, Kyungreem; Hyeon, Seung Jae; Ryu, Hoon; Park, Yong Soo; Kim, Sang Hyun; Kim, In‐Beom; Hong, Gyu-Sang; Lee, Seung Eun; Choi, Yunsook; Cohen, Lawrence B.; Oh, Uhtaek

doi:10.1016/j.pneurobio.2022.102369

Cited by 6 publications

(3 citation statements)

References 71 publications

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“…The papillae develop from a region anterior to the neural plate, which has been postulated to be an olfactory/adenohypophyseal placode homologue, expressing several regulatory genes that are required for olfactory placode development in vertebrates [19][20][21][22][23][24][25][26] . Interestingly, the mammalian TMEM16B/ANO2, TMEM16J/ANO9 proteins are expressed in olfactory sensory neurons (OSNs) and contribute to signaling in the olfactory epithelium [27][28][29][30][31] . This suggests that the role of TMEM/ANO proteins in olfaction emerged in early chordates, and it has been conserved in vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Anoctamins mediate polymodal sensory perception and larval metamorphosis in a non-vertebrate chordate

Liang,

Hoyer,

Chatzigeorgiou

2024

Preprint

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An exceptional feature of most animals is their ability to perceive diverse sensory cues from the environment and integrate this information in their brain to yield ethologically relevant behavioral output. For the myriad of marine species, the ocean represents a complex sensory environment, which acts as a crucible of evolution for polymodal sensory perception. The cellular and molecular bases of polymodal sensory perception in a marine environment remain enigmatic.Here we use Ca2+imaging and quantitative behavioral analysis to show that in the tunicateCiona intestinalistwo members of the evolutionarily conserved Anoctamin family1–4(Tmem16E/Ano5 and Tmem16F/Ano6), are required for sensing chemosensory and mechanosensory metamorphic cues. We find that they act by modulating neuronal excitability and Ca2+response kinetics in the primary sensory neurons and axial columnar cells of the papillae, a widely conserved sensory-adhesive organ across ascidians5–9. Finally, we use electrophysiological recordings and a scramblase assay in tissue culture to demonstrate that Tmem16E/Ano5 acts as a channel, while Tmem16F/Ano6 is a bifunctional ion channel and phospholipid scramblase. Our results establish Ano5 and Ano6 as novel players in the zooplanktonic, pre-vertebrate molecular toolkit that controls polymodal sensory perception in aquatic environments.

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Section: Discussionmentioning

confidence: 99%

Anoctamins mediate polymodal sensory perception and larval metamorphosis in a non-vertebrate chordate

Liang,

Hoyer,

Chatzigeorgiou

2024

Preprint

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“…Little is known about the function of TMEM16J, a member of the TMEM16/anoctamin family of ion channels and phospholipid scramblases 8 . It could form an ion channel, but the evidence was also provided suggesting that it may scramble membrane phospholipids in a Ca 2+ ‐dependent manner 9‐11 . TMEM16J is expressed in renal proximal tubular epithelial cells and immune‐competent tubulointerstitial cells, such as dendritic cells and T‐cells (https://atlas.kpmp.org/explorer/dataviz).…”

Section: Introductionmentioning

confidence: 99%

“…8 It could form an ion channel, but the evidence was also provided suggesting that it may scramble membrane phospholipids in a Ca 2+dependent manner. [9][10][11] TMEM16J is expressed in renal proximal tubular epithelial cells and immune-competent tubulointerstitial cells, such as dendritic cells and T-cells (https://atlas.kpmp.org/explo rer/dataviz). TMEM16J could be, therefore, involved in allograft rejection and renal diseases.…”

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confidence: 99%

ATMEM16Jvariant leads to dysregulated cytosolic calcium which may lead to renal disease

et al. 2022

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Exaggerated immune response is inhibited by extra-and intracellular mechanisms. 1 A genetic region encoding single immunoglobulin interleukin-1 related receptor (SIGIRR), plakophilin 3 (PKP3), and transmembrane 16 protein member J, (TMEM16J, anoctamin 9) was identified as an essential negative regulator of immune response. 2,3 Common single nucleotide polymorphisms (SNPs) in the SIGIRR-PKP3-TMEM16J gene region are associated with tuberculosis, pneumonia, enterocolitis, and kidney graft rejection, and studies of SIGIRR-deficient mice suggest a

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Food odors elicit feeding behavior through the activation of the olfactory system in blunt snout bream (Megalobrama amblycephala)

Yang,

Liu,

Guan

et al. 2024

Aquaculture Reports

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Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

Cited by 6 publications

References 71 publications

Anoctamins mediate polymodal sensory perception and larval metamorphosis in a non-vertebrate chordate

Anoctamins mediate polymodal sensory perception and larval metamorphosis in a non-vertebrate chordate

ATMEM16Jvariant leads to dysregulated cytosolic calcium which may lead to renal disease

Food odors elicit feeding behavior through the activation of the olfactory system in blunt snout bream (Megalobrama amblycephala)

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