Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma

Li, Tao; Xie, Junjie; Shen, Chuan; Cheng, Dongfeng; Shi, Yuan; Wu, Zhichong; Deng, Xiaxing; Chen, Hao; Shen, Baiyong; Peng, Chenghong; Li, Hongwei; Zhan, Qimin; Zhu, Zhenggang

doi:10.1158/0008-5472.can-14-3721

Cited by 258 publications

(240 citation statements)

References 36 publications

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“…28 However, recent studies have shown that ZFAS1 was amplified in hepatocellular carcinoma, colorectal and gastric cancer, and associated with their poor prognosis. 25,29,30 However, the implication of ZFAS1 in glioma progression was still unclear. In this study, we investigated the expression of lncRNA ZFAS1 in glioma tissues as well as in normal brain tissues and further explored the relationship between ZFAS1 and clinicopathological features as well as prognosis of glioma patients.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial–mesenchymal transition in vitro and predicts poor prognosis in glioma

Chen

Zhang

et al. 2017

Tumour Biol.

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Increasing evidence indicates that long noncoding RNAs play important roles in development and progression of various cancers. Zinc finger antisense 1 is a novel long noncoding RNA whose clinical significance, biological function, and underlying mechanism are still undetermined in glioma. In this study, we reported that zinc finger antisense 1 expression was markedly upregulated in glioma and tightly correlated with clinical stage. Moreover, patients with high zinc finger antisense 1 expression had shorter survival. Multivariate Cox regression analysis provided a clue that, probably, zinc finger antisense 1 level could serve as an independent prognostic factor for glioma. Functionally, zinc finger antisense 1 acted as an oncogene in glioma because its knockdown could promote apoptosis and significantly inhibit cell proliferation, migration, and invasion. Furthermore, zinc finger antisense 1 silencing could result in cell cycle arrest at the G0/G1 phase and correspondingly decrease the percentage of S phase cells in both U87 and U251 cell lines. Moreover, it was found that silenced zinc finger antisense 1 could impair migration and invasion by inhibiting the epithelial-mesenchymal transition through reducing the expression of MMP2, MMP9, N-cadherin, Integrin β1, ZEB1, Twist, and Snail as well as increasing E-cadherin level in glioma. Taken together, our data identified that zinc finger antisense 1 might act as a valuable prognostic biomarker and potential therapeutic target for glioma.

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Section: Introductionmentioning

confidence: 99%

Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial–mesenchymal transition in vitro and predicts poor prognosis in glioma

Chen

Zhang

et al. 2017

Tumour Biol.

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“…However, there were opposite findings that elevated lncRNA ZFAS1 occurred in gastric cancer, hepatocellular carcinoma and glioma. The function of lncRNA ZFAS1 in cancer cells might be cell type-dependent [12][13][14][15][16][17][18][19][20]. Therefore, we need a systematical and comprehensive meta-analysis to explore whether overexpression of ZFAS1 in tumor are related to worse outcome.…”

Section: Oncotarget 2 Wwwimpactjournalscom/oncotargetmentioning

confidence: 99%

“…According to the inclusion and exclusion criteria, 747 patients from 8 eligible studies were included in this meta-analysis [12][13][14][15][16][17][18][19]. The screening process was shown in Figure 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In addition, Wang et.al suggested that the upregulated lncRNA ZFAS1 in CRC might be involved in p53 and CDK1/cycliB complex-dependent cell cycle control and apoptosis [18]. Moreover, emerging evidence indicated that the upregulated lncRNA ZFAS1 promoted tumor metastasis of both HCC and ovarian cancer cell through miR-150-dependent manner [14]. Nie et al also revealed that lncRNA ZFAS1 could mediate the carcinogenic effects in GC partially through silencing the KLF2 and NKD2 expression by binding with PRC2 and LSD1 [19].…”

Section: Publication Biasmentioning

confidence: 99%

“…Up to now, the aberrant of lncRNA ZFAS1 was found in various malignancies, including gastric cancer, glioma, breast cancer, hepatocellular carcinoma, and NSCLC, indicating that lncRNAs were critical players in various cancers [13][14][15]26]. The crucial association with LNM, TNM and OS might indicate that lncRNA ZFAS1 could function as a potential biomarker of prognosis in various cancers.…”

Section: Publication Biasmentioning

confidence: 99%

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Prognostic and clinicopathological role of long non-coding RNA ZFAS1 in various carcinomas

Ren¹,

Zhi²,

Shen³

et al. 2017

Oncotarget

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Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer

Sun

et al. 2019

Advanced Science

118

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cancer-associated lncRNA (CCAL), [3] colon cancer-associated transcript 1 (CCAT1) and colon cancer-associated transcript 2 (CCAT2). [4] Since lncRNAs regulate a subset of genes, and are transcriptionally regulated by a series of transcription factors, targeting these lncRNAs induces a much greater effect on cancer cells than targeting single gene. [5] Therefore, exploring the upstream and downstream regulation mechanism of cancer-associated lncRNAs has been gaining widespread attention.As the main effector of the Hippo pathway, Yes-associated protein 1 (YAP1) plays a key role in regulating multiple biological function, including cell-cell contact inhibition, proliferation, and differentiation. [6,7] As a transcription coactivator, YAP1 is abnormally expressed in various malignancies, [8,9] and modulates biological phenotypes of cancer cells via regulating a number of target genes, such as CTGF, CYR61, and AREG. [7,8] Recently, a novel regulatory model of YAP1 transcriptionally regulating the noncoding RNAs (ncRNAs) in CRC has attracted much attention, in which of these noncoding RNAs, including microRNAs (miR-130a [10] and miR-29 [11] ), as well as lncRNAs (RMRP, [12] BCAR4, [13] MALAT1, [14] and lncARSR [15] ). However, the mechanism and As a transcription coactivator, Yes-associated protein 1 (YAP1)'s role in tumorigenesis is well established. However, the mechanism of YAP1-regulating long noncoding RNAs (lncRNA) in tumors is still largely unknown. Here, a YAP1 target gene, long intergenic noncoding RNA 00152 (LINC00152), which is highly expressed in colorectal cancer (CRC), is identified. The oncogenic functions of LINC00152 in CRC are demonstrated by a panel of in vitro and in vivo experiments. Further studies reveal the potential downstream mechanisms of LINC00152, which can act as a competing endogenous RNA sponging with miR-632 and miR-185-3p to regulate Fascin actin-bundling protein 1 (FSCN1) expression and thus promote the malignant proliferation and metastasis in CRC cells. Targeting the YAP1/LINC00152/ FSCN1 axis inhibits the progression of CRC. This finding provides a new regulatory model of the "YAP1-lncRNA" in CRC, which gives rise to a new perspective, "YAP1/LINC00152/miR-632-miR-185-3p/FSCN1," to explore the cancer-promoting mechanism of YAP1 involved in CRC.

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Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma

Cited by 258 publications

References 36 publications

Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial–mesenchymal transition in vitro and predicts poor prognosis in glioma

Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial–mesenchymal transition in vitro and predicts poor prognosis in glioma

Prognostic and clinicopathological role of long non-coding RNA ZFAS1 in various carcinomas

Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer

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