Abstract:Pluripotent stem cells (PSCs) have been reported to exhibit two stages of pluripotency, "primed" and "naïve" states. Typical human PSCs (hPSCs) are in the primed state. Though several methods for conversion from primed to naïve state have been reported, the mechanism of the process is not fully understood. Here, we report that 5′ adenosine monophosphate-activated protein kinase (AMPK) and its downstream p38 is a signaling axis that can induce the naïve conversion of hPSCs with single pathway activation. The si… Show more
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