AMPK-ChREBP axis mediates de novo milk fatty acid synthesis promoted by glucose in the mammary gland of lactating goats

Shi, Hengbo; Jiang, Nannan; Wei, Ling; Cai, Jie; Zhang, Wenying; Jiang, Qianming; Loor, Juan J.; Liu, Jianxin

doi:10.1016/j.aninu.2022.05.003

Cited by 3 publications

(1 citation statement)

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“…Accordingly, AMPK indirectly controls the transcription of lipogenic genes in the mammary gland via SREBP1c phosphorylation. Shi H et al [95] reported that using dorsomorphin, an inhibitor of AMPK, increased the transcription expression of ChREBP and FASN, indicating that glucose-mediated AMPK negatively regulates the de novo biosynthesis of FAs. These findings confirmed that glucose-mediated de novo FA biosynthesis in goat mammary glands relies on the AMPK-ChREBP axis, with ChREBP serving as one of the downstream pathways of AMPK.…”

Section: Adenosine Monophosphate-activated Protein Kinase (Ampk)mentioning

confidence: 99%

Research Progress on the Mechanism of Milk Fat Synthesis in Cows and the Effect of Conjugated Linoleic Acid on Milk Fat Metabolism and Its Underlying Mechanism: A Review

Guo,

Wei,

Zhang

et al. 2024

Animals

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Milk fat synthesis in cows mainly includes the synthesis of short- and medium-chain fatty acids, the uptake, transport, and activation of long-chain fatty acids (LCFAs), the synthesis of triglycerides, and the synthesis of the genes, transcription factors, and signaling pathways involved. Although the various stages of milk fat synthesis have been outlined in previous research, only partial processes have been revealed. CLA consists of an aggregation of positional and geometric isomers of linoleic fatty acid, and the accumulated evidence suggests that the two isomers of the active forms of CLA (cis-9, trans-11 conjugated linoleic acid and trans-10, cis-12 conjugated linoleic acid, abbreviated as c9, t11-CLA and t10, c12-CLA) can reduce the fat content in milk by regulating lipogenesis, fatty acid (FA) uptake, oxidation, and fat synthesis. However, the mechanism through which CLA inhibits milk fat synthesis is unique, with most studies focusing only on the effects of CLA on one of the genes, transcription factors, or signaling pathways involved. In this study, we summarized the structure and function of classic genes and pathways (mTOR, SREBP, AMPK, and PPARG) and new genes or pathways (THRSP, METTL3, ELOVL, and LPIN1) involved in each stage of milk fat synthesis and demonstrated the interactions between genes and pathways. We also examined the effects of other substances (melanin, nicotinic acid, SA, etc.). Furthermore, we evaluated the influence of β-sitosterol, sodium butyrate, Met arginine, and Camellia oleifera Abel on milk fat synthesis to improve the mechanism of milk fat synthesis in cows and provide a mechanistic reference for the use of CLA in inhibiting milk fat biosynthesis.

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Section: Adenosine Monophosphate-activated Protein Kinase (Ampk)mentioning

confidence: 99%