AMPK Alchemy: Therapeutic Potentials in Allergy, Aging, and Cancer
Ram Hari Pokhrel,
Suman Acharya,
Sunil Mishra
et al.
Abstract:All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates and affects various biological processes, such as lipid/glucose metabolism and protein synthesis. These actions further affect the cell growth, death, and functions, altering the cellular outcomes in energy-restric… Show more
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