Ampicillin/sulbactam: Its potential use in treating infections in critically ill patients

Adnan, Syamhanin; Paterson, David L.; Lipman, Jeffrey; Roberts, Jason A.

doi:10.1016/j.ijantimicag.2013.07.012

Cited by 50 publications

(37 citation statements)

References 68 publications

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“…This ␤-lactam/␤-lactamase inhibitor combination has been approved by the FDA for treatment of skin, gynecological, and intra-abdominal infections (16). Although sulbactam is used clinically as a ␤-lactamase inhibitor, it also has inherent antibacterial activity against a limited number of bacterial species, including Neisseria gonorrhoeae, Bacteroides fragilis, and, fortuitously, Acinetobacter spp.…”

mentioning

confidence: 99%

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

Penwell

Shapiro

Giacobbe

et al. 2015

Antimicrob Agents Chemother

173

136

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Sulbactam is a class A ␤-lactamase inhibitor with intrinsic whole-cell activity against certain bacterial species, including Acinetobacter baumannii. The clinical use of sulbactam for A. baumannii infections is of interest due to increasing multidrug resistance in this pathogen. However, the molecular drivers of its antibacterial activity and resistance determinants have yet to be precisely defined. Here we show that the antibacterial activities of sulbactam vary widely across contemporary A. baumannii clinical isolates and are mediated through inhibition of the penicillin-binding proteins (PBPs) PBP1 and PBP3, with very low frequency of resistance; the rare pbp3 mutants with high levels of resistance to sulbactam are attenuated in fitness. These results support further investigation of the potential clinical utility of sulbactam.

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mentioning

confidence: 99%

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

Penwell

Shapiro

Giacobbe

et al. 2015

Antimicrob Agents Chemother

173

136

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“…These infections include ear infections, bladder infections, pneumonia and gonorrhoea. The drug is also employed in the treatment of skin and skinstructure infections, intro-abdominal infections and gynaecological infections (Adnan et al, 2013). The antibiotic is known for its ability to penetrate the gram positive bacteria and in some cases the gram negative ones.…”

Section: Ajabsmentioning

confidence: 99%

“…The antibiotic is known for its ability to penetrate the gram positive bacteria and in some cases the gram negative ones. Ampicillin is noted for its amino acids that help to attack the formed membranes of gram negative bacteria (Adnan et al, 2013). It also works against the enzyme transpeptidase, which is a basic component needed by the bacteria to form the membranes that surround them.…”

Section: Ajabsmentioning

confidence: 99%

“…In effect, the function of both drugs is to prevent the membranes of the bacteria from fully forming so that the antibodies, other humoral substances and cells of the human immune system can penetrate them and remove them. It is established that bacteria by itself cannot survive inside the human body without the protective walls that surround it (Adnan et al, 2013).…”

Section: Ajabsmentioning

confidence: 99%

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EVALUATING THE SENSITIVITY OF PSEUDOMONAS AERUGINOSA, ESCHERICHIA COLI AND SALMONELLA TYPHI TO VARIOUS BRANDS OF AMPICILLIN AND AMOXICILLIN AVAILABLE IN NIGERIA

Anomohanran¹,

Owhe-Ureghe²,

Ehwarieme³

2014

American Journal of Agricultural and Biological Sciences

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The failure of antimicrobial agents in the treatment of some ailments has become a great concern to health care practitioners. This could be as a result of low quality drugs, sneaked into the market by those who fake them, thus, this study was carried out to evaluate the sensitivity of various brands of Amoxicillin and Ampicillin on clinical isolates of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi. The test organisms were clinical bacterial isolates obtained from clinical samples from four hospitals/laboratories in Delta State, Nigeria. The antibiotics were subjected to two fold serial dilution method to determine the Minimum Inhibitory Concentration (MIC) from which the sensitivity of the isolates to the various brands of the antibiotics was determined. The result showed that the sensitivity of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to the various brands of Amoxicillin are 54, 62 and 68% respectively. The result also revealed that the sensitivity of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to Ampicillin are 64, 64 and 70% respectively. The result further indicates that a mean sensitivity of the isolates to Amoxicillin was 61%, while the mean sensitivity to Ampicillin was obtained as 66%. The study has therefore established the need for a routine evaluation of antibiotics and other pharmaceuticals in the Nigerian markets.

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“…One of these approaches is to expand the use of antibiotics by using them in combination with compounds that inhibit resistance pathways [5]. For example, clavulanic acid, tazobactam and sulbactam are β-lactamase inhibitors that have been used successfully in combination with β-lactams antibiotics, and they have prolonged and expanded their effectiveness [6][7][8]. Aminoglycoside, macrolide and lincosamide antibiotics are also susceptible to enzyme-mediated deactivation through phosphorylation by kinases [9][10][11][12][13].…”

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confidence: 99%

Raf-Kinase Inhibitor Gw5074 Shows Antibacterial Activity Against Methicillin-Resistant Staphylococcus Aureus and Potentiates the Activity of Gentamicin

et al. 2016

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Aim:Increasing antimicrobial resistance has compromised the effectiveness of many antibiotics, including those used to treat staphylococcal infections like methicillinresistant Staphylococcus aureus. The development of combination therapies, where antimicrobial agents are used with compounds that inhibit resistance pathways is a promising strategy. Results/methodology: The Raf kinase inhibitor GW5074 exhibited selective in vitro activity against Gram-positive bacteria, including clinical isolates of S. aureus with a minimum inhibitory concentration (MIC) of 2-8 μg/ml. GW5074 was effective in vivo in the Galleria mellonella infection model. The compound showed synergy with gentamicin by lowering MIC by fourfold, compared with gentamicin MIC alone. Conclusion: This work demonstrates the antimicrobial properties of GW5074 and supports further investigation of the kinase inhibitors as antibiotic adjuvants.

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Ampicillin/sulbactam: Its potential use in treating infections in critically ill patients

Cited by 50 publications

References 68 publications

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

EVALUATING THE SENSITIVITY OF <i>PSEUDOMONAS AERUGINOSA</i>, <i>ESCHERICHIA COLI</i> AND <i>SALMONELLA TYPHI</i> TO VARIOUS BRANDS OF AMPICILLIN AND AMOXICILLIN AVAILABLE IN NIGERIA

Raf-Kinase Inhibitor Gw5074 Shows Antibacterial Activity Against Methicillin-Resistant Staphylococcus Aureus and Potentiates the Activity of Gentamicin

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