Ampicillin-resistant and vancomycin-susceptible <i>Enterococcus faecium</i> bacteremia: a clinical narrative review

Sorlí, Luisa; Navarrete-Rouco, María Eugenia; Prim, Núria; Barceló-Vidal, Jaime; Conde-Estévez, David; Montero, María Milagro; Martín-Ontiyuelo, Clara; Horcajada, Juan Pablo; Echeverría-Esnal, Daniel

doi:10.1080/14787210.2023.2223977

Expert Review of Anti-infective Therapy

2023

DOI: 10.1080/14787210.2023.2223977

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Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review

Luisa Sorlí

María Eugenia Navarrete-Rouco

Núria Prim

et al.

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2024

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Cited by 2 publications

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“…Enterococcus faecium , deemed a high-priority pathogen by the WHO, exhibits resistance to multiple antibiotics including fluoroquinolones, vancomycin, penicillins, and other antibiotics . The prevalence of vancomycin-resistant E. faecium (VRE) has rapidly increased over the past decade, particularly VRE bloodstream infections, which are correlated with notable morbidity and mortality, with mortality rates ranging from 20% to 50%. , Given the increasing prevalence of VRE and the continuous emergence of new variants, there is an acute necessity to explore novel antibiotics.…”

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confidence: 99%

Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A–C from the Endophytic Fungus Epicoccum sp. 1-042

Chang,

Li,

Huang

et al. 2024

J. Nat. Prod.

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Bioactivity-based molecular networking-guided fractionation enabled the isolation of three new polycyclic tetramic acids bearing cis-decalin, epicolidines A−C (1−3), along with one known compound, PF 1052 (4), from the endophytic fungus Epicoccum sp. 1-042 collected in Tibet, China. Their structures were assigned on the basis of extensive spectroscopic data, partial hydrolysis, advanced Marfey's method, quantum chemistry calculations, and X-ray diffraction analysis. Compounds 2−4 displayed promising activities against Gram-positive bacteria in vitro. Particularly, compound 4 displayed remarkable potential against vancomycin-resistant Enterococcus faecium (VRE) with an MIC value of 0.25 μg/mL, lower than the MIC (0.5 μg/mL) of the antibiotic combination quinupristin/dalfopristin (Q/D). In a further in vivo study, compound 4 increased the survival rate to 100% in the VRE-G. mellonella infection model at a concentration of 10 mg/kg.

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confidence: 99%

Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A–C from the Endophytic Fungus Epicoccum sp. 1-042

Chang,

Li,

Huang

et al. 2024

J. Nat. Prod.

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Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria

Zhang,

Liao,

Ding

et al. 2024

Antibiotics

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Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems by producing β-lactamases. Therefore, a combination of β-lactam antibiotics with β-lactamase inhibitors has been a promising approach to controlling β-lactam-resistant bacteria. The discovery of novel β-lactamase inhibitors (BLIs) is essential for effectively treating antibiotic-resistant bacterial infections. Therefore, this review discusses the development of innovative inhibitors meant to enhance the activity of β-lactam antibiotics. Specifically, this review describes the classification and characteristics of different classes of β-lactamases and the synergistic mechanisms of β-lactams and BLIs. In addition, we introduce potential sources of compounds for use as novel BLIs. This provides insights into overcoming current challenges in β-lactamase-producing bacteria and designing effective treatment options in combination with BLIs.

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Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review

Cited by 2 publications

References 117 publications

Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A–C from the Endophytic Fungus Epicoccum sp. 1-042

Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A–C from the Endophytic Fungus Epicoccum sp. 1-042

Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria

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