Amphotericin B and Other Polyenic Antifungal Antibiotics

Jo, Lampen

doi:10.1093/ajcp/52.2.138

Cited by 99 publications

(1 citation statement)

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“…Simo et al [22] reported that acetal linkage-containing hydrophilic N-(2-(tetrahydoro-2H-pyna-2-yl)oxy)ethyl acrylamide (HEAmTHP) was polymerized via reversible addition-fragmentation chain transfer (RAFT) radical polymerization using a hydrophobic poly(2-hydroxyethyl acrylate) (PHEA) macro-chain transfer agent (CTA) to prepare an amphiphilic diblock copolymer (PHEA-PHEAmTHP). In a subsequent study [23], the encapsulation of a hydrophobic antibiotic substance in the hydrophobic domain of formed PHEA-PHEAmTHP micelles in water was performed. Another study by Gold et al investigated the effects of attached Amphotericin B to the the cell membrane of micro-organisms, which showed antibiotic property by breaking membrane structures [24].…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Block Copolymers Bearing Hydrophobic γ-Tocopherol Groups with Labile Acetal Bond

et al. 2019

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High concentrations of γ-tocopherol (γTCP) tend to show antioxidant, anti-inflammatory, and anticancer effects. In this study, we prepared polymer micelles under acidic conditions with a controlled release of γTCP due to the decomposition of pendant acetal bonds. First, a precursor diblock copolymer composed of poly(ethylene glycol) (PEG) and acrylic acid (AA) was prepared. This was followed by the synthesis of an amphiphilic diblock copolymer (PEG54-P(AA/VE6/γTCP29)140), incorporated into hydrophobic γTCP pendant groups attached to the main chain through an acetal bond. The prepared PEG54-P(AA/VE6/γTCP29)140 was further dispersed in water to form polymer micelles composed of hydrophobic cores that were generated from a hydrophobic block containing γTCPs and hydrophilic shells on the surface. Under acidic conditions, γTCP was then released from the core of the polymer micelles due to the decomposition of the pendant acetal bonds. In addition, polymer micelles swelled under acidic conditions due to hydration of the core.

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Section: Introductionmentioning

confidence: 99%

Amphiphilic Block Copolymers Bearing Hydrophobic γ-Tocopherol Groups with Labile Acetal Bond

et al. 2019

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Changes in free cholesterol content, measured by filipin fluorescence and flow cytometry, correlate with changes in cholesterol biosynthesis in THP‐1 macrophages

Hassall

Graham

1995

Cytometry

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The fkee cholesterol content of cells can be monitored by the intensity of fluorescence emissions from the polyene antibiotic filipin. In a previous study (Hassall: Cytometry 13331-388, 1992) using THP-1 macrophages, a decrease in filipin fluorescence in response to increasing concentrations of modified lipoprotein was observed, suggesting a reduction in the free cholesterol content of the cells. In this study, THP-1 macrophages were treated with a number of agents known to modulate cholesterol biosynthesis and cholesterol esterification. Changes in fdipin fluorescence emissions were measured by flow cytornetry, and correlated with changes in cholesterol biosynthesis measured by incorporation of [l*C]acetate into cholesterol. A correlation between decreases in filipin fluorescence and reductions in cholesterol biosynthesis was apparent, even when cholesterol esterification was inhibited. These results suggest that the decreases in filipin fluorescence observed may be due, at least in part, to reductions in cholesterol biosynthesis.G 1995 Wiley-Liss, Inc.

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Transport and fate of diethyl phthalate in aquatic ecosystems

Lewis

Holm

Kollig

et al. 1984

Enviro Toxic and Chemistry

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Sorption, alkaline hydrolysis, photolysis and microbial transformation of diethyl phthalate (DEP) were studied in a large laboratory aquatic ecosystem composed of a series of reactor tanks. Microbial transformation accounted for 95 to 99% of the rapid loss of DEP from water. First‐order rate coefficients for the loss of DEP, except in reactor tanks depleted of inorganic nutrients, were statistically constant among diverse chemical and microbial environments, suggesting a constant transformation rate per unit of colonized surface area. The diversities of reactor tank environments were substantiated by large ranges in the dissolved organic carbon, nitrogen, phosphorus, chlorophyll, ATP and biomass measurements. Microbial transformation of DEP resulted specifically from bacterial activity, most of which was associated with aquatic microbial growth (aufwuchs) attached to submerged surfaces or suspended in streamers or mats.

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Amphotericin B and Other Polyenic Antifungal Antibiotics

Cited by 99 publications

References 0 publications

Amphiphilic Block Copolymers Bearing Hydrophobic γ-Tocopherol Groups with Labile Acetal Bond

Amphiphilic Block Copolymers Bearing Hydrophobic γ-Tocopherol Groups with Labile Acetal Bond

Changes in free cholesterol content, measured by filipin fluorescence and flow cytometry, correlate with changes in cholesterol biosynthesis in THP‐1 macrophages

Transport and fate of diethyl phthalate in aquatic ecosystems

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