Amphiregulin promotes the proliferation of trophoblast cells during preimplantation development of porcine embryos

Lee, J.H.; Lee, E.; Biswas, Dibyendu; Jeung, C.S.; Lee, G.S.; Hyun, Sang‐Hwan; Jeung, Eui‐Bae

doi:10.1016/j.theriogenology.2009.05.021

Cited by 11 publications

(13 citation statements)

References 36 publications

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“…Cell-cell communication network analysis also revealed that PAMM1a might signal to villous cytotrophoblast and syncytiotrophoblast in an EGFR-dependent fashion, through the secretion of amphiregulin (AREG), epiregulin (EREG) and heparin-binding EGF-like growth factor (HBEGF) [determined through analysis of whole-genome sequencing data, deposited at ArrayExpress E-MTAB-6701 (35)]. These factors are known to be important in driving trophoblast proliferation and differentiation (59)(60)(61)(62)(63)(64). Therefore, PAMM1a are likely driving both the repair and regeneration of the placental surface in the first trimester of human pregnancy.…”

Section: The Functional Properties Of First Trimester Pammmentioning

confidence: 99%

The Ontogeny and Function of Placental Macrophages

et al. 2021

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The placenta is a fetal-derived organ whose function is crucial for both maternal and fetal health. The human placenta contains a population of fetal macrophages termed Hofbauer cells. These macrophages play diverse roles, aiding in placental development, function and defence. The outer layer of the human placenta is formed by syncytiotrophoblast cells, that fuse to form the syncytium. Adhered to the syncytium at sites of damage, on the maternal side of the placenta, is a population of macrophages termed placenta associated maternal macrophages (PAMM1a). Here we discuss recent developments that have led to renewed insight into our understanding of the ontogeny, phenotype and function of placental macrophages. Finally, we discuss how the application of new technologies within placental research are helping us to further understand these cells.

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Section: The Functional Properties Of First Trimester Pammmentioning

confidence: 99%

The Ontogeny and Function of Placental Macrophages

et al. 2021

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“…Interestingly, many direct or indirect HOXB9 target genes identified in distinct contexts [47, 85–87] are expressed in TE. AMPHIREGULIN is an EGF-like peptide involved in TE cell proliferation in the mouse and pig [91, 92]. In the pig, AMPHIREGULIN expression profile is similar to the one observed for the bovine HOXB9 [92].…”

Section: Discussionmentioning

confidence: 98%

“…AMPHIREGULIN is an EGF-like peptide involved in TE cell proliferation in the mouse and pig [91, 92]. In the pig, AMPHIREGULIN expression profile is similar to the one observed for the bovine HOXB9 [92]. TGF-β2, another HOXB9 target, is detected in the mouse [93, 94] and pig [95] TE cells and is present in the fetal and maternal components of the bovine placentome [96, 97].…”

Section: Discussionmentioning

confidence: 99%

Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals

et al. 2016

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BackgroundWe previously showed that the homeodomain transcription factor HOXB9 is expressed in mammalian oocytes and early embryos. However, a systematic and exhaustive study of the localization of the HOXB9 protein, and HOX proteins in general, during mammalian early embryonic development has so far never been performed.ResultsThe distribution of HOXB9 proteins in oocytes and the early embryo was characterized by immunofluorescence from the immature oocyte stage to the peri-gastrulation period in both the mouse and the bovine. HOXB9 was detected at all studied stages with a dynamic expression pattern. Its distribution was well conserved between the two species until the blastocyst stage and was mainly nuclear. From that stage on, trophoblastic cells always showed a strong nuclear staining, while the inner cell mass and the derived cell lines showed important dynamic variations both in staining intensity and in intra-cellular localization. Indeed, HOXB9 appeared to be progressively downregulated in epiblast cells and only reappeared after gastrulation had well progressed. The protein was also detected in the primitive endoderm and its derivatives with a distinctive presence in apical vacuoles of mouse visceral endoderm cells.ConclusionsTogether, these results could suggest the existence of unsuspected functions for HOXB9 during early embryonic development in mammals.

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“…A total of 618 duplicated articles were removed; 1679 articles were excluded based on their titles and abstracts; and a further 22 articles were excluded on full-text review. Sixteen studies [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] qualified for analysis. The study selection process and reasons for excluding the 22 studies are detailed in the flowchart in Figure 1.…”

Section: Literature Retrieval and Summary Of Included Articlesmentioning

confidence: 99%

Association of High-Volume Centers With Survival Outcomes Among Patients With Nontraumatic Out-of-Hospital Cardiac Arrest

et al. 2022

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Key Points Question Is treatment at a high-volume center associated with improved survival and neurological outcomes among adult patients with nontraumatic out-of-hospital cardiac arrest (OHCA)? Findings In this systematic review and meta-analysis of 16 articles involving 82 769 patients with OHCA, survival to discharge or 30 days improved with treatment at a high-volume center; there was no association between center volume and good neurological outcomes at 30 days or at hospital discharge. Meaning These findings suggest that treatment at a high-volume center may improve survival but not neurological outcomes in patients with OHCA; more studies evaluating the relative importance of center volume compared with other variables associated with survival outcomes in these patients are required.

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Amphiregulin promotes the proliferation of trophoblast cells during preimplantation development of porcine embryos

Cited by 11 publications

References 36 publications

The Ontogeny and Function of Placental Macrophages

The Ontogeny and Function of Placental Macrophages

Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals

Association of High-Volume Centers With Survival Outcomes Among Patients With Nontraumatic Out-of-Hospital Cardiac Arrest

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