Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts

Wang, Shen-Wu; Oh, Chad K.; Cho, Seong H.; Hu, Guanghui; Martin, Rachel E.; Demissie-Sanders, Sossiena; Li, Kang; Moyle, Matthew; Yao, Zhengbin

doi:10.1016/j.jaci.2004.11.037

Cited by 82 publications

(76 citation statements)

References 26 publications

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“…In this study, we confirmed that AR stimulated lung fibroblast proliferation (36) and further demonstrated a novel regulatory role for AR that mediates TGF-␤1-stimulated fibroblast proliferation, myofibroblast transformation, and ECM accumulation.…”

Section: Discussionsupporting

confidence: 77%

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

Zhou

Lee

Cho

et al. 2012

Journal of Biological Chemistry

127

137

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Section: Discussionsupporting

confidence: 77%

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

Zhou

Lee

Cho

et al. 2012

Journal of Biological Chemistry

127

137

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“…Further, an increase in mast cells as identified by tryptase staining occurs near mucosal gland stroma in non-fatal asthma, while an increase in degranulated mast cells near mucosal glands is observed in fatal and non-fatal asthma [45]. Of recent interest is the role of amphiregulin that is produced by mast cells following FceRI aggregation which leads to an increase in mucin gene expression in epithelial cells [46,47].…”

Section: Asthmamentioning

confidence: 99%

The mast cell and allergic diseases: role in pathogenesis and implications for therapy

Brown

Wilson

Metcalfe

2007

Clin Experimental Allergy

239

184

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SummaryMast cells have long been recognized for their role in the genesis of allergic inflammation; and more recently for their participation in innate and acquired immune responses. Mast cells reside within tissues including the skin and mucosal membranes, which interface with the external environment; as well as being found within vascularized tissues next to nerves, blood vessels and glandular structures. Mast cells have the capability of reacting both within minutes and over hours to specific stimuli, with local and systemic effects. Mast cells express the high affinity IgE receptor (FceRI) and upon aggregation of FceRI by allergen-specific IgE, mast cells release and generate biologically active preformed and newly synthesized mediators which are involved in many aspects of allergic inflammation. While mast cells have been well documented to be essential for acute allergic reactions, more recently the importance of mast cells in reacting through pattern recognition receptors in innate immune responses has become recognized. Moreover, as our molecular understanding of the mast cell has evolved, novel targets for modulation have been identified with promising therapeutic potential.

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“…More recently, mast cell expression of amphiregullin, a member of the epidermal growth factor family, was increased in asthma and this upregulates mucin gene expression by epithelial cells, implicating amphiregullin in goblet cell metaplasia and mucus hypersecretion [79,80]. Similarly, neutrophils may promote mucus hypersecretion by upregulation of MUC5AC by neutrophil elastase [81,82].…”

Section: Inflammatory Cell Localisation To Mucus Glandsmentioning

confidence: 99%

Inflammatory cell microlocalisation and airway dysfunction: cause and effect?

Siddiqui

Hollins²,

Saha³

et al. 2007

European Respiratory Journal

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Airway inflammation is a critical feature of the airway diseases asthma and chronic obstructive pulmonary disease (COPD). There is emerging evidence that structural cells play a key role in the development and perpetuation of the inflammatory response and are pivotal in the development of the changes in the airway structures that lead to airway remodelling.To date, little attention has been given to the localisation of inflammatory cells to airway structures or the potential interactions between these intimately located cells. However, it is likely that interactions between inflammatory and structural cells in the airway contribute enormously to the pathophysiology of asthma and COPD.Indeed, recent evidence suggests that mast cells localised to the airway smooth muscle bundle may be important in the development of airway hyperresponsiveness in asthma.In the present article, the authors aim to summarise: 1) the current understanding of which inflammatory cells locate to airway structures; 2) the proposed mechanisms that may be involved in mediating this microlocalisation; 3) the possible consequences of interactions between inflammatory and structural cells; and 4) the pressing need to investigate whether modulating these interactions is beneficial in asthma and chronic obstructive pulmonary disease.

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Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts

Cited by 82 publications

References 26 publications

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

The mast cell and allergic diseases: role in pathogenesis and implications for therapy

Inflammatory cell microlocalisation and airway dysfunction: cause and effect?

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