Amphiphilic Star Copolymer‐Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacteria Detection and Inhibition

Li, Yamin; Yu, Hansen; Qian, Yinfeng; Hu, Jinming; Liu, Shiyong

doi:10.1002/adma.201402797

Cited by 128 publications

(104 citation statements)

References 71 publications

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“…The different binding affinities of certain cationic polymers for disease-causing bacteria have recently been exploited to detect pathogens [41][42][43][44] or to discriminate between Gram-positive and Gram-negative bacteria and fungi [45]. It has been suggested that negative charges arising from teichoic acids are responsible for the higher binding of polycations with Gram-positive bacteria.…”

Section: Discussionmentioning

confidence: 99%

Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers

Louzao

Sui

Winzer

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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New anti-infective materials are needed urgently as alternatives to conventional biocides. It has recently been established that polymer materials designed to bind to the surface of bacteria can induce the formation of cell clusters which enhance the expression of quorum sensing controlled phenotypes. These materials are relevant for anti-infective strategies as they have the potential to inhibit adhesion while at the same time modulating Quorum Sensing (QS) controlled virulence. Here we carefully evaluate the role that charge and catechol moieties in 2 these polymers play on the binding. We investigate the ability of the cationic polymers poly(N- (5, 7 and 8) and polymer concentration (0.1 and 0.5 mg/mL). We identify that clustering ability is strongly dependent on the balance between charge and hydrophobicity. Moreover, our results suggest that catechol moieties have a positive effect on adhesive properties, but only in the presence of cationic residues such as for P2. Overall, our results highlight the subtle interplay between dynamic natural surfaces and synthetic materials, as well as the need to consider synergistic structure-property relationship when designing antimicrobial polymers.

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Section: Discussionmentioning

confidence: 99%

Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers

Louzao

Sui

Winzer

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…Recently, a special fluorescent system with aggregation‐induced emission (AIE) characteristic has been discovered by Tang's group and widely applied to various biomedical fields . Up to now, All MRI probes used in AIE‐based dual‐mode imaging are Gd chelates, a T 1 contrast agent . Although Gd chelates dominate the main market of MRI contrast agents, the U.S. Food and Drug Administration (FDA) has given the highest black box warning of this agent for causing nephrogenic systemic fibrosis in patients with kidney disfunctions .…”

Section: Introductionmentioning

confidence: 99%

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Cai

Liu

et al. 2019

J of Applied Polymer Sci

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Fluorescence/magnetic resonance (MR) dual‐mode imaging, which combines the excellent single‐cell sensitivity of fluorescence imaging and the high spatial resolution of MR imaging, has been applied to different biomedical applications. However, the aggregation‐caused quenching characteristic of most fluorescence molecules often put limits in their applications. Herein, a fluorescence/MR dual‐mode imaging probe [polyethylene glycol‐polyethylenimine‐tetraphenylethene (PEG‐PEI‐TPE)/superparamagnetic iron oxide (SPIO)] with aggregation‐induced emission characteristic is prepared by coupling poly(acrylic acid)‐coated SPIO with PEG‐PEI‐TPE. The fluorescence intensity and lifetime of PEG‐PEI‐TPE/SPIO is higher than PEG‐PEI‐TPE especially at lower polymer concentrations (≤0.2 mg mL−1). Moreover, the fluorescence intensity of PEG‐PEI‐TPE/SPIO gradually increased along with the decline of the pH from 9.0 to 4.0, which is beneficial for studying intracellular organelles. The T2 relaxivity of PEG‐PEI‐TPE/SPIO is 212.3 Fe mM−1 s−1 under a 3.0 T MR scanner. Cell labeling experiment shows that PEG‐PEI‐TPE/SPIO can effectively label RAW 264.7 and Hela cells, and labeled cells are visible under both fluorescence and clinical MR examinations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48760.

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“…Amphiphilic block copolymers have been attracting attention for years due to their ability to form different types of self‐assemblies in aqueous environment which find use in biomedical applications, for example, drug carriers, sensors, fluorogenic nanostructures and vehicles for the transportation of biological molecules such as DNA, RNA, and proteins . Among polymer nanostructures such as micelles, nanocapsules, polymersomes, block copolymer micelles (BCMs) come into prominence due to enhanced permeability and retention (EPR) effect, small particle size, high loading capacity, prolonged circulation, and accumulation in the required pathological site(s) in the body …”

Section: Introductionmentioning

confidence: 99%

Preparation of Layer‐by‐Layer Films with Remarkably Different pH‐Stability and Release Properties Using Dual Responsive Block Copolymer Micelles

Gundogdu

Bütün

Erel-Göktepe

2018

Macro Chemistry & Physics

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Layer‐by‐layer (LbL) films of micelles of poly[2‐(dimethylamino)ethyl methacrylate]‐b‐poly[(2‐(diethylamino)ethyl methacrylate)] (PDMA‐b‐PDEA) and poly(sodium 4‐styrenesulfonate) (PSS) with remarkably different pH‐stability and release properties are obtained via tuning film deposition conditions in a narrow pH and temperature range. Multilayers constructed at pH 8.5/25 °C or pH 8/30 °C completely disintegrate at physiologically related conditions, whereas film deposition at pH 8/25 °C produces stable films under the same conditions. Importantly, despite their stability, pH 8/25 °C multilayers release a considerable amount of pyrene at moderately acidic pH due to disintegration of the micellar cores. The amount of pyrene increases significantly at body temperature due to lower critical solution temperature (LCST)‐type phase behavior of PDMA coronal chains. The difference in properties of multilayers is explained by the extent of association among the layers which can be tuned by film deposition conditions in a narrow pH and temperature range due to dual responsive, that is, pH and temperature behavior of PDMA‐b‐PDEA micelles.

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Amphiphilic Star Copolymer‐Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacteria Detection and Inhibition

Cited by 128 publications

References 71 publications

Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers

Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Preparation of Layer‐by‐Layer Films with Remarkably Different pH‐Stability and Release Properties Using Dual Responsive Block Copolymer Micelles

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