Amphiphilic Poly(<scp>d</scp>- or <scp>l</scp>-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) Block Copolymers: Controlled Synthesis, Characterization, and Stereocomplex Formation

Spasova, Mariya; Mespouille, Laetitia; Coulembier, Olivier; Paneva, Dilyana; Manolova, Nevena; Rashkov, Iliya; Dubois, Philippe

doi:10.1021/bm801515c

Cited by 67 publications

(85 citation statements)

References 32 publications

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“…These copolymers have potential for the use in pharmaceutical and biomedical applications as sutures, implants for bone fixation, drug delivery systems, and tissue engineering scaffolds [105,107,111]. ATRP has been utilized to prepare well-defined polyester-based amphiphilic block copolymers with hydrophilic poly(meth)acrylates, including poly(2-methacryloyloxyetheyl phosphorylcholine) [112], poly( N , N -dimethylaminoethyl methacrylate) (PDMAEMA) [113–115], and PHEMA [116]. …”

Section: Drug Delivery Systemsmentioning

confidence: 99%

ATRP in the design of functional materials for biomedical applications

Siegwart

Matyjaszewski

2012

Progress in Polymer Science

514

364

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Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

ATRP in the design of functional materials for biomedical applications

Siegwart

Matyjaszewski

2012

Progress in Polymer Science

514

364

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“…Poly(N,N-dimethylaminoethyl) methacrylate (PDMAEM) attracts researchers' attention for a long time. It exhibits antimicrobial and fungicidal properties; it is one of the most effective polymers for the DNA transport; it is also used as flocculant in mining industry [1][2][3][4][5][6][7]. PDMAEM is a weak base.…”

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confidence: 99%

Conformation properties of poly(N,N-dimethylaminoethyl methacrylate) macromolecules in various solvents

et al. 2012

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Poly(N,N-dimethylaminoethyl methacrylate) macromolecules in the un-ionized and ionized states were studied by methods of molecular hydrodynamics, optics, and polarized luminescence. The conformation, relaxation, and optical parameters of the macromolecules were determined. The Mark-Kuhn-Houwink equations were obtained for the intrinsic viscosity and diffusion and sedimentation coeffi cients. Poly(N,N-dimethylaminoethyl) methacrylate (PDMAEM) attracts researchers' attention for a long time. It exhibits antimicrobial and fungicidal properties; it is one of the most effective polymers for the DNA transport; it is also used as flocculant in mining industry [1][2][3][4][5][6][7]. PDMAEM is a weak base. Its temperaturesensitive properties and conformation of macromolecules are determined by the nature of the solvent (pH, ionic strength, kind of counteranions) [8][9][10][11][12][13][14]. Signifi cant role is also played by the molecular weight and architecture of PDMAEM macromolecules [12].Determination of the molecular weights and dimensions of macromolecules of amphiphilic polymers and polyelectrolytes still involves problems because of the occurrence of intra-and intermolecular interactions. This particularly concerns polyelectrolytes, because they are characterized by two oppositely acting factors: hydrophobic interaction and Coulomb repulsion. The fi rst factor leads to enhancement of intra-and intermolecular interactions which decrease the hydrodynamic volume, whereas the electrostatic forces tend to increase the volume of polymeric coils, i.e., the hydrodynamic volume. Salt additions can shield the polyelectrolytic effect but enhance the hydrophobic intramolecular interactions. Hydrophobic contacts can be broken by adding organic solvents or surfactants.In this study we determined the molecular, conformation, optical, and relaxation properties of PDMAEM in the forms of the base and salt in dilute solutions. To this end, we used the methods of molecular hydrodynamics (sedimentation, diffusion, viscometry) and optics (fl ow birefringence, polarized luminescence). EXPERIMENTAL PDMAEM was prepared by free-radical polymerization of DMAEM in benzene, toluene, or isopropanol solution at 60°С with azobis(isobutyronitrile) (AIBN) as initiator or in aqueous solution at 25°С with a 1 : 1 mixture of (NH 4 ) 2 S 2 O 8 and N,N,N',N'-tetramethylethylenediamine as initiator (Table 1).The polymer with a luminescence label was prepared by free-radical copolymerization of DMAEM with 9-anthrylmethylmethacrylamide; the concentration of the monomers in the isopropanol solution was 15 wt %, and the AIBN concentration, 1.5 wt % relative to the monomers. The content of luminescence labels in the polymer did not exceed 0.2 mol %.The intrinsic viscosities were measured by the standard procedure in the Ostwald capillary viscometer. For

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“…The stereocomplex phase has higher melt temperature than neat PLA. It is well-known that PLA stereocomplexs have thermal resistance significantly higher from the initial enantiomeric PLA [29,[43][44][45]. The position of the crystallization and melting peaks depends on the multiblock copolymer.…”

Section: Thermal Analysismentioning

confidence: 99%