Amphiphilic poly(amino acid) based micelles applied to drug delivery: The in vitro and in vivo challenges and the corresponding potential strategies

Xu, He‐Lin; Yao, Qing; Cai, Cuifang; Gou, Jinxin; Zhang, Yu; Zhong, Hongshan; Tang, Xing

doi:10.1016/j.jconrel.2014.12.012

Cited by 136 publications

(82 citation statements)

References 114 publications

(127 reference statements)

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“…28−31 Because of the advantages of reserving drugs in the hydrophobic core and prolonged circulation time, they have become promising nanocarriers for the controlled release of hydrophobic anticancer drugs. 32,33 As a kind of nanomaterials, polymeric micelles can accumulate in the tumor tissues through an enhanced permeability and retention (EPR) effect and are able to concentrate into cells. The physiochemical properties (i.e., shape, size, and electric charge) of the micelles and the nature of the target cells such as either the phagocytosis or the other endocytic pathways (i.e., clathrin-and calveolae-mediated endocytosis) would have important impacts.…”

Section: ■ Introductionmentioning

confidence: 99%

Shape Transformation of Light-Responsive Pyrene-Containing Micelles and Their Influence on Cytoviability

2015

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The amphiphilic pyrene-containing random copolymers with light-responsive pyrene ester bonds were synthesized by copolymerizing 1-pyrenemethyl acrylate (PA) and N,N-dimethylacrylamide (DMA). The P(DMA-co-PA) copolymers formed spherical micelles in water, which were transformed into nanorods as a result of cleavage of the pyrene ester bonds under UV irradiation. In vitro culture with A549 cells and Raw cells showed that compared to the nonphotodegradable ones, the photodegradable P(DMA-co-PA) micelles caused significantly higher cytotoxicity under the same UV irradiation. The intracellular reactive oxygen species (ROS) level had a positive correlation with the cytotoxicity regardless of the cell types. The nonphotodegradable pyrene-containing micelles produced a lower level of ROS under UV irradiation. However, the photodecomposable P(DMA-co-PA) micelles produced a significant higher level of ROS under the same trigger of UV irradiation, which caused the shape transformation of micelles to nanorods and higher cytotoxicity simultaneously.

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Section: ■ Introductionmentioning

confidence: 99%

Shape Transformation of Light-Responsive Pyrene-Containing Micelles and Their Influence on Cytoviability

2015

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“…Poly(amino acid) or its derivatives, one kind of important biocompatible and biodegradable polymers, are widely used as biomedical materials due to their availability of side functional groups [57,58,59,60,61]. Synthetic polypeptides, especially poly( l -glutamic acid), poly( l -aspartic acid) and poly( l -lysine), could be modified due to the reactive side groups and could self-assemble into micelles, vesicles, and solid nanoparticles with controlled drug delivery capabilities.…”

Section: Pba-functionalized Materials and Polymersmentioning

confidence: 99%

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

Huang

Liu

et al. 2017

Materials

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In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes.

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“…Naturally occurring !-amino acid based polymers have gathered considerable attention over recent years as biodegradable, biocompatible and functional materials having various characteristics such as amphoteric nature [1,2], chiral recognition [3], drug delivery [4,5], response to stimuli [6][7][8][9][10][11][12] and self-organization via supramolecular interactions [13][14][15]. In past studies, amino acid-based side chain polymers had been mainly synthesized by conventional or controlled free radical polymerizations of amino acids whose N-or C-terminals are modified with (meth)acrylamide [1-4, 10-12, 14, 16-22] or (meth)acrylate groups [6][7][8][9][23][24][25][26][27].…”

Section: T1 Introductionmentioning

confidence: 99%

Amino acid-incorporated polymer network by thiol-ene polymerization

Yokose¹,

Shimasaki²,

Teramoto³

et al. 2015

Express Polym. Lett.

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Abstract. Triallyl L-alanine (A3A) and triallyl L-phenylalanine (A3F) were synthesized by reactions of L-alanine and L-phenylalanine with allyl bromide in the presence of sodium hydroxide, respectively. Thiol-ene thermal polymerization of A3A or A3F with pentaerythritol-based primary tetrathiol (pS4P) or pentaerythritol-based secondary tetrathiol (S4P) at allyl/SH 1/1 in the presence of 2,2"-azobis(isobutyronitrile) produced an amino acid-incorporated polymer network (A3A-pS4P, A3A-S4P or A3F-S4P). Although the thermally cured resins were homogeneous and flat films, the corresponding thiol-ene photopolymerization did not give a successful result. Degree of swelling for each thermally cured film in N,Ndimethylformamide was much higher than that in water. The glass transition and 5% weight loss temperatures (T g and T 5 ) of A3F-pS4P and A3F-S4P were higher than those of A3A-pS4P and A3A-S4P, respectively. Also, A3F-pS4P and A3F-S4P exhibited much higher tensile strengths and moduli than A3A-pS4P and A3A-S4P did, respectively. Consequently, A3F-pS4P displayed the highest T g (38.7°C), T 5 (282.0°C), tensile strength (9.5 MPa) and modulus (406 MPa) among all the thermally cured resins.

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Amphiphilic poly(amino acid) based micelles applied to drug delivery: The in vitro and in vivo challenges and the corresponding potential strategies

Cited by 136 publications

References 114 publications

Shape Transformation of Light-Responsive Pyrene-Containing Micelles and Their Influence on Cytoviability

Shape Transformation of Light-Responsive Pyrene-Containing Micelles and Their Influence on Cytoviability

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

Amino acid-incorporated polymer network by thiol-ene polymerization

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