Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents

Miao, Qinghua; Xu, Dongxue; Wang, Zhi; Xu, Lina; Wang, Tiewei; Wu, Yan; Lovejoy, David B.; Kalinowski, Danuta S.; Richardson, Des R.; Nie, Guangjun; Zhao, Yuliang

doi:10.1016/j.biomaterials.2010.06.012

Cited by 47 publications

(38 citation statements)

References 39 publications

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“…NPs increase the stability of chemical agents by encapsulation, protecting these agents from the extracellular environment and regulating the drug release in a prolonged and controllable manner. [6][7][8][9] Furthermore, NPs can be engulfed into cells by phagocytosis and actively transfer the cargoes, chemical agents and nucleotides, into cells.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Zhao¹,

Li²,

Shi³

et al. 2014

IJN

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Nanoparticles (NPs) which target specific agents could effectively recognize the target cells and increase the stability of chemical agents by encapsulation. As such, NPs have been widely used in cancer treatment research. Recently, over 90% of treatment failure cases in patients with metastatic cancer were attributed to resistance to chemotherapy. Surface-exposed glucose-regulated protein of 78 kDa (GRP78) is expressed highly on many tumor cell surfaces in many human cancers and is related to the regulation of invasion and metastasis. Herein, we report that NPs conjugated with antibody against GRP78 (mAb GRP78-NPs) inhibit the adhesion, invasion, and metastasis of hepatocellular carcinoma (HCC) and promote drug delivery of 5-fluorouracil into GRP78 high-expressed human hepatocellular carcinoma cells. Our new findings suggest that mAb GRP78-NPs could enhance drug accumulation by effectively transporting NPs into cell surface GRP78-overexpressed human hepatocellular carcinoma cells and then inhibit cell proliferation and viability and induce cell apoptosis by regulating caspase-3. In brief, mAb GRP78-NPs effectively inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Zhao¹,

Li²,

Shi³

et al. 2014

IJN

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“…Gao et al 13 prepared dual functional nanoparticles composed of PEG-foliate acid polymers for the chemotherapy drug doxorubicin. Miao et al 14 synthesized an amphiphilic copolymer with hyper-branched poly(amine-ester)-co-PLA to generate nanoparticles for the controlled delivery of antitumor agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of biocompatible poly(ε-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles

Nanaki¹,

Pantopoulos²,

Bikiaris³

2011

IJN

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Poly(propylene adipate)-block-poly(ε-caprolactone) copolymers were synthesized using a combination of polycondensation and ring-opening polymerization of ε-caprolactone in the presence of poly(propylene adipate). Gel permeation chromatography was used for molecular weight determination, whereas hydrogen-1 nuclear magnetic resonance and carbon-13 nuclear magnetic resonance spectroscopy were employed for copolymer characterization and composition evaluation. The copolymers were found to be block while their composition was similar to the feeding ratio. They formed semicrystalline structures, while only poly(ε-caprolactone) formed crystals, as shown by wide angle X-ray diffraction. Differential scanning calorimetry data suggest that the melting point and heat of fusion of copolymers decreased by increasing the poly(propylene adipate) amount. The synthesized polymers exhibited low cytotoxicity and were used to encapsulate desferrioxamine, an iron-chelating drug. The desferrioxamine nanoparticles were self-assembled into core shell structures, had mean particle size ,250 nm, and the drug remained in crystalline form. Further studies revealed that the dissolution rate was mainly related to the melting temperature, as well as to the degree of crystallinity of copolymers.

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“…For example, MWCNTs can activate NF-κB, enhance phosphorylation of MAP kinase pathway components, and increase generation of proinflammatory cytokines in bronchial epithelial cells [90]. However, Zhong et al showed that carbon black did not induce changes in DNA migration in V79 or Hel 299 cells [92]. Carboxylated MWCNTs did not have any significant effect on cellular morphology and viability of PC12 cells at lower concentrations.…”

Section: Carbon Nanotubes (Cnts) and Cellmentioning

confidence: 96%

Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review

Louis¹

2017

EJB

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Abstract:Although numerous studies have investigated the interaction between nanoparticles and biological systems (proteins, cells, tissues, membrane etc.), and the growing interests of nanotoxicity of these engineered nanoparticles, much remains to be investigated. First, there are various factors to be explored, such as the physical or chemical properties of materials, different cell lines, and the systematic study of specific materials. Secondly, architectural structure (shape) conditions of NPs have not been well investigated and undestood. Third, the variations in cell line result in different cell uptake, toxicity, or transportation in the same materials, but systematic studies of this phenomenon are scanty. Fourth, the nanotoxicity issue and the accumulation of non-degradable materials relating to biosafety are yet to be understood. Fifth, the transformation of NMs' surface chemistry in living creatures is too complicated to investigate. In this article, we review the biophysicochemical mechanisms of the various interactions between nanomaterials and biological systems (proteins, cells, membrane). With the rapid increase in studies related to nanotechnology, investigations on nanomaterials can be more beneficial than others because of their size. A comprehensive understanding of nano-bio interactions can serve as a foundation for future biomedical applications.

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Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents

Cited by 47 publications

References 39 publications

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Synthesis of biocompatible poly(ε-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles

Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review

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Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents

Cited by 47 publications

References 39 publications

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles

Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review

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Synthesis of biocompatible poly(ε-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles