Amphiphilic drug–peptide–polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: the effect of conjugate aggregation on in vitro activity

Abstract

EGFR targeting drug–polymer–peptide conjugates have enhanced solubility wherein in vitro biological activity highly depends on the structure of conjugates due to their amphiphilic character and self-aggregation properties.

Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?

“…YIGSR peptide conjugated dendrimer peptides are selective for HCT-116 cells with LR (Leptin receptor) 46 . Gemcitabine was released intracellularly which led to cell death 47 .…”

Peptide-Based Low Molecular Weight Photosensitive Supramolecular Gelators

“…In addition to this, they can possess unique specific functions like cell targeting and environmental responsiveness owing to their bio-active nature [ 36 ]. Chemically, the side chains, free amino (–NH 2 ), and carboxyl (–COOH) terminus further open up ample opportunities to integrate drugs [ 37 , 38 ], carriers [ 39 , 40 ], and other functional molecules of interest. Due to the chiral nature of the amino acids (except Glycine (Gly)), often, molecular chirality gets transferred to the supramolecular level causing nano-structures with specific chirality [ 41 , 42 , 43 ].…”

Supramolecular grafting of stimuli-responsive, carrier-free, self-deliverable nanoparticles of camptothecin and antisense DNA for combination cancer therapy

“…Recently, the design strategy of amphiphilic systems 7,8 has been applied for the creation of self-deliverable nanosystems for anticancer drugs. 9 In this approach, typically a hydrophobic anticancer drug is covalently conjugated to a hydrophilic segment such as an oligonucleotide, 10 a short peptide 11 or an oligo ethylene glycol chain 12 through a cleavable linker. Owing to the inherent amphiphilicity of the resulting prodrug, they spontaneously self-assemble into nanoparticles with high drug loading efficacy.…”