Amphiphilic dendronized homopolymers

Li, Wen; Zhang, Afang

doi:10.1007/s11426-010-4136-3

Cited by 11 publications

(3 citation statements)

References 36 publications

(45 reference statements)

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“…30 The cylindrical wormlike morphology of these polymers is important to shield the interior structures with the peripheral units. [31][32][33] For example, the thermoresponsiveness of oligoethylene glycol (OEG)-based dendronized polymers is dominated by the peripheral units, irrespective of their hydrophobic or hydrophilic interiors. [34][35][36] Their thickness has been proven to be responsible for the unprecedented thermoresponsiveness of these dendronized representatives and their heterogeneous dehydration, 37,38 and can mediate the transition of guest molecules during thermally-induced aggregation processes.…”

Section: Wen LImentioning

confidence: 99%

Dendronized supramolecular polymers

Yan

Zhang

2014

Chem. Commun.

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Supramolecular polymers formed from topological building blocks pave a new avenue for creating novel supramolecular structures and functional materials. Dendronized supramolecular polymers (DSPs) combine the topological characteristics of dendronized polymers and a dynamic nature from supramolecular chemistry, and are promising for the formation of supramolecular structures and functional assemblies. These topological supramolecular polymers have a characteristic cylindrical shape, high rigidity, multivalency, as well as inherent thickness. These structural characteristics make them ideal candidates for supramolecular assembly. DSPs can be formed through non-covalent interactions, such as hydrogen bonding, π-π stacking, and metal coordination, and classified into main-chain, side-chain and block types. This feature article will summarize methodologies for the preparation of homo- and block DSPs with a focus on their supramolecular structure formation. Particular attention is put on the structural effects of DSPs on their supramolecular assembly.

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Section: Wen LImentioning

confidence: 99%

Dendronized supramolecular polymers

Yan

Zhang

2014

Chem. Commun.

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“…They pointed out the polymer architecture shows big influence on their phase transitions, as the LCSTs of the hyperbranched polymers are normally 5–10 deg lower than that of the linear counterparts. Alternatively, we reported recently a series of thermoresponsive polymers with OEG linkages based on dendronized polymer concept (from PG1 to PG3). , These polymers combine the structural characteristics from dendronized polymers, including the bulkiness, cylindrical molecular shape, and high rigidity with a more or less stretched backbone in the interior, together with the unique properties of OEG units. They were prepared via conventional radical polymerization in bulk and could be achieved with high molar masses.…”

Section: Introductionmentioning

confidence: 99%

Comblike Thermoresponsive Polymers with Sharp Transitions: Synthesis, Characterization, and Their Use as Sensitive Colorimetric Sensors

Liu

et al. 2011

Macromolecules

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The synthesis and thermoresponsive behavior of two structural novel comblike polymers are presented, which are constituted by polymethacrylates main chain with dendritic oligoethylene glycol (OEG) side groups spaced with a linear hydrophobic alkyl [PG1(A)] or hydrophilic OEG unit [PG1(G)]. The design of this comblike architecture is to retain the unique thermoresponsive behavior of OEG-based dendritic polymers and, on the other side, to eliminate the tremendous synthesis effort for the dendronized polymer analogues. Their thermoresponsive behavior was investigated with UV/vis and temperature-varied 1H NMR spectroscopy to determine their apparent LCSTs and follow chain dehydration process, respectively. These polymers show sharp and fast transitions with small hystereses. The phase transition temperatures are located in between 27 and 34 °C, which is in the vicinity of physiological temperature, and these transition temperatures are independent of polymer concentration. The thermoresponsiveness of these polymers is also compared with the corresponding macromonomers as well as the densely packed dendronized polymer analogues reported previously, focusing on chemical structure and architecture effects. It was found that the more hydrophobic polymer PG1(A) could form denser aggregates than that of the more hydrophilic polymer PG1(G). On the basis of the exceptional thermoresponsive behavior of these comblike polymers, this architecture is utilized for fabricating polymer sensors. Random copolymerization of the macromonomers with the monomer bearing solvatochromic dye moiety (Disperse Red 1) affords the thermoresponsive copolymers which act as sensitive dual-sensors for both temperature and pH value.

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“…Li et al applied Monte Carlo simulation to investigate kinetic behavior of one-pot hyperbranched polymerization based on AA*-CB 2 [25]. Zhang's group has efficiently synthesized a series of second generation of amphiphilic dendronized homopolymers, and has described their thermoresponsiveness in aqueous solutions and secondary structures in methanol solutions [26]. Liu and his colleagues developed a facile synthesis method for dendrimerlike star-branched poly(N-isopropylacrylamide) (PNIPAM) via the combination of click chemistry and atom transfer radical polymerization (ATRP) by employing the arm-first approach [27].…”

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Focus on polymer chemistry papers in Science China Chemistry of the year 2010

2011

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The journal Science China Chemistry published 63 papers in polymer fields in 2010, leading to a percentage increase of 473% compared to the year 2008 and 70% to the year 2009, respectively (Figure 1). In this year, three polymer Special Topics were designed and published: Biomedical Polymer (Number 3) [1], Advances in Principles of Polymerization (Number 8) [2] and Highly Branched Polymers-Promising Architectural Macromolecules (Number 12) [3]. Several high qualified papers were published and great achievements have been obtained in the year 2010.The Special Topic of Biomedical Polymers was organized by Prof. GAO ChangYou and GU ZhongWei. According to these papers one knows that the applications of biomedical polymers are focusing on drug release [4-8] and gene delivery [9,10]. For the drug release system, a great number of materials can be utilized such as supermolecule, block copolymers, hyperbranched polymers, etc. Yan et al. synthesized a series of hyperbranched copolymers and explored their applications, especially in drug release [4,11,12].In their researches, two kinds of novel temperature-responsive hyperbranched multiarm copolymers were successfully synthesized via the atom transfer radical polymerization (ATRP). Poly(3-ethyl-3-(hydroxymethyl) oxetane) (HBPO) core and thermosensitive poly(N-isopropylacrylamide) (PNIPAM) arms were synthesized from NIPAM monomers by using a hyperbranched HBPO macroinitiator. Moreover, poly(L-lactide) (PLA) inner-shell and poly(ethylene glycol) (PEG) outer-shell with disulfide-linkages between the hydrophobic and hydrophilic moieties was developed as unimolecular micelles. The HBPO-star-PNIPAM self-assembled micelles showed much improved drug encapsulation efficiencies and temperature-dependent sustainable release behavior due to the special micellar structure. The micelles exhibited no apparent cytotoxicity against human HeLa cells. The H40-star-PLA-SS-PEG bioreducible unimolecular micelles were proved as promising carriers for the triggered intracellular delivery of hydrophobic anticancer drugs. Gu's review discussed peptide dendrimers synthesis and functionalization and their applications in biomedicine for drug release and gene delivery [13]. There are two main advantages of the peptide dendrimers, i.e. the size controllable synthesis even to nanometers and the good biocompatibility due to their similar properties as proteins. Therefore, the peptide dendrimers have received considerable attention in biomedicine. They also investigated a novel supramolecular nanoparticle, and studied the drug release behavior and the anti-tumor effects. The results demonstrate that the supramolecular nanoparticles are biocompatible and are promising carriers for drug delivery. Zhang et al. discussed several kinds of stimulus-responsive nanoparticles, including pH-responsive, temperature-responsive, lightresponsive, magnetic-responsive, ultrasound-responsive, pH/

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Amphiphilic dendronized homopolymers

Cited by 11 publications

References 36 publications

Dendronized supramolecular polymers

Dendronized supramolecular polymers

Comblike Thermoresponsive Polymers with Sharp Transitions: Synthesis, Characterization, and Their Use as Sensitive Colorimetric Sensors

Focus on polymer chemistry papers in Science China Chemistry of the year 2010

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